Immunosuppression Flashcards
(30 cards)
Innate/Non-specific immunity
always there/always present; doesn’t need to be “turned on”
First and second-line defense
First line defense (3 things)
Surface protection
Physical, chemical and genetic
Second-line defense (4 things)
Cellular and chemical system
Phagocytosis, Inflammation, Fever, Antimicrobial proteins
Aqcuired/Specifdic
needsto develop; encounter specific antigen first
includes specific response for one particular type of pathogen
What 2 types of acquired immunity do we have?
Active vs inactive
Active immunity
actively producing antibodies/t cells
Passive iummunity
receiving from another source; placenta
*can also be produced in a lab
Immune system cytokines (5)
- interleukins
- interferons
- growth factors
- tumor necrosis factor
- chemokines
interleukins
signals among leukocytes
interferons
antiviral proteins that may act as cytokines; draw in WBCs
growth factors
proteins in bone marrow that stimulate stem cells to divide
tumor necrosis factor
secreted by macrophages and t cells to kill tumor cells/regulate immune responses & inflammation
chemokines
chemotactic cytokines that signal leukocytes to move to infectious site and surround it
type 1 hypersensitivity
immediate response; anyphylaxis
type 2 hypersensitivity
antibody mediated; blood type incompatibilities
type 3 hypersensitivity
immune complex (antigen binds to antibody and builds larger structures)
rheumatoid arthritis
type 4 hypersensitivity
ONLY ONE W/O ANTIBODIES
cell-mediated cytotoxic; t cells w/ delayed response
Ex: poison ivy, contact dermatitis, graft rejection
DiGeorge syndrome
no thymus - no t cells
agammaglobinemeia
no b cells - no antibodies
severe combined immunodeficiencey disorder (SCID)
no B or T cells
acquired immune deficiency syndrom
associated w/ HIV; secondary/acquired
who is more affected with autoimmunity?
females
SLE
autoantibodies against DNA
MS
autoantibodies and t-cells against neurons, myelin
