Immunosuppression and Inflammation Flashcards Preview

Pharmacology > Immunosuppression and Inflammation > Flashcards

Flashcards in Immunosuppression and Inflammation Deck (24):
1

Sodium cromoglycate

Used to treat conditions associated with mast cell degranulation. Inhibits mast cell degranulation. Mechanism of action unclear but may inhibit Cl- conductance that is required to maintain a negative enough membrane potential to enable sustained influxes of Ca.

2

Salbutamol/salmeterol

Beta2-adrenoceptor agonists. Used in asthma to inhibit mast cells as well as causing bronchodilation.

3

Theophylline

PDE inhibitor. Used in asthma to inhibit mast cells as well as causing bronchodilation.

4

Omalizumab

Monoclonal antibody that recognises IgE. IgE with its high affinity receptor FceRI induces phosphorylation of adaptor protein linker for activation of T cells that cause activation of PLCbeta/IP3 mediated release.

5

Mepyramine

First generation antihistamine. Rapidly permeates BBB so causes drowsiness. Used in creams for treatment of insect bites.

6

Promethazine

First generation antihistamine. Used as a sedative, to treat motion sickness and severe morning sickness.

7

Terfenadine

Second generation antihistamine. Does not cross BBB. But causes prolonged QT interval due to inhibition of KvII.I/hERG important for repolarisation of AP. In conditions of diminished p450 3A4 (e.g. due to grapefruit juice) gives enhanced risk of death.

8

Fexofenadine

Third generation antihistamine. Active compound of terfenadine by p450 3A4.

9

Loratadine

Third generation antihistamine. Non-drowsy and no cardiac side effects.

10

What is administered in the case of anaphylactic shock and why?

Adrenaline. Counteracts systemic vasodilatation and reduction in tissue perfusion. Also relieves bronchospasm.

11

Omeprazole

Inhibits proton pump. Used in treating gastric ulcers.

12

Ranitidine

H2 receptor antagonist. Used in treating gastric ulcers.

13

Clarithromycin/metronidazole

Antibiotics used to eradicate Helicobacter Pylori for treatment of gastric ulcers.

14

Misoprostol

PGE1 analogue. Prescribed alongside NSAIDs in elderly patients at risk of developing gastric ulcers to act as EP1/2 receptors to enhance mucus secretion.

15

Athrotec

Combination of NSAID diclofenac and mesoprostol (PGE1 analogue). Used to treat rheumatoid arthritis.

16

C1-INH

Kallikrein inhibitor (C1 esterase inhibitor)

17

Kalbitor

Kallikrein inhibitor. Used to treat hereditary angioedema.

18

Tanezumab

Monoclonal antibody against Nerve Growth Factor.

19

Telcagepant

CRGP antagonist currently in trials.

20

Metoclopramide

D2 antagonist - emesis.

21

Scopolamine

M1 antagonist - emesis.

22

Mepyramine

H1 antagonist - emesis.

23

Dramamine

H1 antagonist/M1 antagonist - emesis.

24

'setrons e.g. ondansetron

5-HT3 antagonist - emesis.