Flashcards in Immunosuppression and Inflammation Deck (24):
Used to treat conditions associated with mast cell degranulation. Inhibits mast cell degranulation. Mechanism of action unclear but may inhibit Cl- conductance that is required to maintain a negative enough membrane potential to enable sustained influxes of Ca.
Beta2-adrenoceptor agonists. Used in asthma to inhibit mast cells as well as causing bronchodilation.
PDE inhibitor. Used in asthma to inhibit mast cells as well as causing bronchodilation.
Monoclonal antibody that recognises IgE. IgE with its high affinity receptor FceRI induces phosphorylation of adaptor protein linker for activation of T cells that cause activation of PLCbeta/IP3 mediated release.
First generation antihistamine. Rapidly permeates BBB so causes drowsiness. Used in creams for treatment of insect bites.
First generation antihistamine. Used as a sedative, to treat motion sickness and severe morning sickness.
Second generation antihistamine. Does not cross BBB. But causes prolonged QT interval due to inhibition of KvII.I/hERG important for repolarisation of AP. In conditions of diminished p450 3A4 (e.g. due to grapefruit juice) gives enhanced risk of death.
Third generation antihistamine. Active compound of terfenadine by p450 3A4.
Third generation antihistamine. Non-drowsy and no cardiac side effects.
What is administered in the case of anaphylactic shock and why?
Adrenaline. Counteracts systemic vasodilatation and reduction in tissue perfusion. Also relieves bronchospasm.
Inhibits proton pump. Used in treating gastric ulcers.
H2 receptor antagonist. Used in treating gastric ulcers.
Antibiotics used to eradicate Helicobacter Pylori for treatment of gastric ulcers.
PGE1 analogue. Prescribed alongside NSAIDs in elderly patients at risk of developing gastric ulcers to act as EP1/2 receptors to enhance mucus secretion.
Combination of NSAID diclofenac and mesoprostol (PGE1 analogue). Used to treat rheumatoid arthritis.
Kallikrein inhibitor (C1 esterase inhibitor)
Kallikrein inhibitor. Used to treat hereditary angioedema.
Monoclonal antibody against Nerve Growth Factor.
CRGP antagonist currently in trials.
D2 antagonist - emesis.
M1 antagonist - emesis.
H1 antagonist - emesis.
H1 antagonist/M1 antagonist - emesis.