Immunosupression

Question 1

corticosteroid MOA

Answer 1

1) prostaglandin 2)lymphocyte 3)phagocytosis

Question 2

Cyclophsophamide

Answer 2

cytotoxic, alkylates guanine

Question 3

mycophenolate mofetil

Answer 3

inhibits im pdh, prevents guanine synthesis (CT drug)

Question 4

azathioprine

Answer 4

6-mercaptopurine. block de novo purine synthesis. TPMT

Question 5

methotrexate

Answer 5

dihydrofolate reductase (DHFR) get macrocytic megaloblastic anaemia)

Question 6

Plasmapheresis

Answer 6

remove Ab or enxchange plasma

1. ab mediated disease (MG, GP)
2. Ab mediated rejection

Question 7

Tacrolimus

Answer 7

Calcineurin inhibitor (IL-2) transplant rejection

Question 8

cyclosporin

Answer 8

Calcineurin inhibitor

Question 9

sirolimus

Answer 9

calcineurin

Question 10

tofacitinib

Answer 10

JAK inhibitor (RA)

Question 11

apremilast

Answer 11

PDE4 inhibitor (psoriasis)

Question 12

Basilixab

Answer 12

anti-CD25 (IL2) allograft rejection

Question 13

abatercept

Answer 13

anti-CTLA4 (RA)

Question 14

rituximab

Answer 14

anti-CD20 (leukocyte migration) lymphoma, RA, SLE

Question 15

natalizumab

Answer 15

anti-alpha4 intergin (relapse remitting MS, crohns)

Question 16

tocilzumab

Answer 16

anti-IL6 (castle mans, RA)

Question 17

Muromonab-CD3

Answer 17

Block CD3, active allograft rejection

Question 18

anti-thymocyte globulin (ATG)

Answer 18

causes lymphocyte depletionallograft rejection

Question 19

Daclizumab

Answer 19

IL-2 receptor Ab, target CD25 (organ transplant rejection)

Question 20

efalizumab

Answer 20

anti CDIIa

Question 21

alemtuzemab

Answer 21

monoclonal abs binds to CD52 (CLL, MS)

Question 22

infliximab

Answer 22

anti-tif alpha (RA, AS, Psoriasis, IBD)

Question 23

certolizumab

Answer 23

anti TNF alpha

Question 24

etancerpet

Answer 24

TNF alpha/ TNF beta fusion protien

Question 25

Golimumab

Answer 25

TNF alph

Question 26

Ustekinumab

Answer 26

anti-IL12 and anti-IL23 (psoriasis)

Question 27

Secukimumab

Answer 27

anti-IL17A (psoriasis)

Question 28

Denosumab

Answer 28

anti-RANK ligand (osteoporosis, MM, bone mets)