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Pathology > Immunotherapies2 > Flashcards

Immunotherapies2 Flashcards

1
Q

Give 3 indications for Plasmpharesis

A

Myasthenia Gravis
Goodpastures Syndrome
Vascular Rejection

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2
Q

Name 5 inhibitors of cell signalling

A 
Tacrolimus
Cyclosporin 
Sirolimus
Tofacitinib
Apremilast
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3
Q

Which drug is a JAK2 inhibitor indicated in Rheumatoid arthritis?

A

Tafocitinib

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4
Q

What is the mechanism of action of cyclosporine and tacrolimus?

A

Inhibit calcineurin which normally activates transcription of IL2 hence reduces T cell proliferation

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5
Q

Which cell signal inhibitor is indicated in psoriasis and psoriatic arthritis?

A

Apremilast

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6
Q

What is the mechanism of action of apremilast?

A

PDE4 inhibitor

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7
Q

What cytokines is inhibited by cyclosporine?

A

IL2

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8
Q

What are the 4 side effects of tacrolimus?

A

Nephrotoxic
Hypertension
Neurotoxic
Diabetogenic

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9
Q

Name an Anti-CD25 agent

A

Basiliximab

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10
Q

What is the mechanism of action of Abatacept?

A

Anti-CTLA4-Ig

Reduces T cel activation

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11
Q

Name the anti-cd20 drug which depletes mature B cells

A

Rituximab

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12
Q

What is an indications for Abatacept?

A

Rheumatoid Arthritis

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13
Q

When would you use basiliximab

A

Allograft rejection

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14
Q

What are the indications for rituximab?

A

B cell lymphomas,
Rheumatoid Arthritis
SLE

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15
Q

Which drug is an anti-alpha4 integrin which inhibits T cell migration by binding to VCAM and MadCAM1 to arrest leukocytes?

A

Natalizumab

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16
Q

What is the mechanism of action of tocilizumab ?

A

Anti-IL6 receptors

Reduces macrophage, T cell, B cell and neutrophil activation

17
Q

Which drug blocks CD3 on T cells by blocking mouse monoclonal antibody (OKT3)?

A

Muromonab-CD3

18
Q

What drug is indicated in relapsing and remitting MS?

A

Natalizumab

19
Q

Which drugs have a risk of leading to PML?

A

Rituximab

Natalizumab

Pathology (4 decks)

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