Important cytokines Flashcards
What cytokines are secreted by macrophages
IL-1, IL-6, IL-8, IL-12, TNF-a
What cytokines are secreted by all T cells
IL-2 and IL-3
What cytokines are secreted by Th2 cells
IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-13
IL-1
AKA osteoclast-activating factor
Causes fever and acute inflammation
Activates endothelium to express adhesion molecules
Induces chemokine secretion to recruit leukocytes
IL-2
Increases clonal expansion
Stimulates growth of all T cells
IL-3
Supports growth and differentiation of BM stem cells
Acts like GM-CSF
IL-4
Stimulates B-cell proliferation Induces Naive T cells into Th2 Enhances class switching to IgE and IgG
IL-5
Promotes differentiation of B cells.
Enhances class switching to IgA
Stimulates growth and differentiation of eosinophils
IL-6
Endogenous pyrogen
Secreted by Th2 cells
Causes fever, stimulates acute-phase protein production
IL-8
Major chemotactic factor for neutrophils
“Clean up on Aisle 8” - IL-8 recruits neutrophils to clear infections
IL-10
Modulates/inhibits inflammatory response Inhibits activated T cells and Th1 Secreted by Treg cells Similar to TGF-b inhibits macrophage activation
IL-12
Differentiates Naive Th into Th1
Activates NK cells
Is secreted by B cells
IFN-gamma
Secreted by Th1 cells
Activates NK cells to kill virus-infected cells
Increases MHC expression and antigen presentation in all cells
What cytokines are secreted by Th1 cells
IFN-g, IL-2
What inhibits TH1 cell
IL-4 and IL-10 from Th2 cell
