Inclusions/Protein Aggregates

Question 1

Alzheimer’s Disease (3)

Answer 1

Neuritic Plaques (silver, thioflavin S, APP/AB)
Neurofibrillary Tangles/Neuropil threads (silver, phospho-tau)
Cerebral amyloid angiopathy (thioflavin S, APP/AB)

Question 2

Neuritic Plaques (+stains, 3)

Answer 2

Silver (Bielschowsky)
Thioflavin-S
APP/AB

Question 3

Neurofibrillary Tangles/Neuropil Threads (+stains, 2)

Answer 3

Silver (Bielschowsky)
Phospho-tau

Question 4

Cerebral Amyloid Angiopathy (+stains, 2)

Answer 4

Thioflavin-S
APP/AB

Question 5

Dementia with Lewy Bodies (DLB)/Idiopathic Parkinsons Disease (iPD)

Answer 5

Lewy Bodies (alpha-synuclein, ubiquitin)

Question 6

Lewy Bodies (+stains, 2)

Answer 6

Alpha-synuclein
Ubiquitin

Question 7

Progressive Supranuclear Palsy (PSP) (4)

Answer 7

Subcortical globose tangles (silver, phospho-tau)
Grumose degeneration of cerebella’s dentate nucleus (silver)
Coiled bodies in glia (silver, phopho-tau)
Tufted astrocytes (silver, phospho-tau)

Question 8

Subcortical globose tangles (+stains, 2)

Answer 8

PSP
-silver
-phospho-tau

Question 9

Grumose degeneration of cerebellar dentate (+stains, 1)

Answer 9

PSP
-silver

Question 10

Coiled bodies in glia (+stains, 2)

Answer 10

PSP
-silver
-phospho-tau

Question 11

Tufted Astrocytes (+stains, 2)

Answer 11

PSP
-silver
-phospho-tau

Question 12

Corticobasal Degeneration (CBD) (4)

Answer 12

Ballooned neurons (phosphorylated neurofilament proteins)
Corticobasal inclusions (silver, phospho-tau)
Coiled bodies in glia (silver, phospho-tau)
Astrocytic plaques (silver, phospho-tau)

Question 13

Ballooned Neurons (+stains, 1)

Answer 13

CBD
-phosphorylated neurofilament protein

Question 14

Corticobasal inclusions (+stains, 2)

Answer 14

CBD
-Silver
-Phosopho-tau

Question 15

Coiled bodies in glia (+stains, 2)

Answer 15

CBD & PSP
-Silver
-Phosopho-tau

Question 16

Astrocytic Plaques (+stains, 2)

Answer 16

CBD
-Silver
-Phosopho-tau

Question 17

Multiple Systems Atrophy (MSA) (1)

Answer 17

Glial cytoplasmic inclusions in Oligodendrocytes
- Silver
- Alpha-synuclein
- Ubiquitin

Question 18

Glial cytoplasmic inclusions in Oligodendrocytes (+stains, 3)

Answer 18

Multiple Systems Atrophy (MSA)
- Silver
- Alpha-synuclein
- Ubiquitin

Question 19

Pick Disease (2)

Answer 19

Pick bodies (silver, phospho-tau)
Pick cells (phosphorylated neurofilament proteins)

Question 20

Pick bodies (+stains, 2)

Answer 20

Silver
Phospho-tau

Question 21

Pick Cells (diseases-3, +stain-1)

Answer 21

Pick Disease, FTLD-tau, FTLD-U
-Phosphorylated Neurofilament protein

Question 22

Frontotemporal Lobar Degeneration with tau inclusions (FTLD-tau) (2)

Answer 22

Pick cells (phosphorylated neurofilament protein)
Glial cytoplasmic inclusions (silver, phospho-tau)

Question 23

Glial cytoplasmic inclusions (+stains, 2)

Answer 23

FTLD-tau
-Silver
-phospho-tau

Question 24

Frontotemporal Lobar Degeneration with ubiquinated inclusions (FTLD-U) (2)

Answer 24

Pick Cells (phosphorylated neurofilament protein)
Cytoplasmic and nuclear inclusions (ubiquitin, TDP-43)

Question 25

Cytoplasmic and Nuclear Inclusions (+stains, 2)

Answer 25

FTLD-U -TDP-43 -Ubiquitin

Question 26

Creutzfeldt-Jakob Disease (CJD) (1)

Answer 26

Amyloid plaques of prion protein deposition (PrP)

Question 27

Amyloid plaques of prion protein deposition (+stain)

Answer 27

CJD -PrP