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Certificate of Specialty Pharmacy > Indication and dosing > Flashcards

Indication and dosing Flashcards

(48 cards)

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1
Q

Humira dose on RA/PsA/AS

A

400mg every 2 weeks

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2
Q

Humira dosing on Uveitis/PP/HS

A

80mg then 40mg every 2 weeks, beginning 1 week after initial dose

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3
Q

Humira dosing on HS

A

160mg on day 1 then 80mg on day 15 then 40mg weekly or 80mg every 2 weeks on day 29

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4
Q

Humira dosing on CD/UC

A

160mg day 1 then 80mg on day 15 then 40mg every 2 weeks beginning on day 29

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5
Q

Enbrel dosing on RA/PsA/AS

A

50mg weekly

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6
Q

Enbrel dosing on PP

A

50mg twice weekly for 3 months then 50mg weekly

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7
Q

Cimzia dosing on RA/AS/nr-axSpA/PsA

A

400mg weeks 0, 2, 4 then 400mg ever 4 weeks or 200mg every 2 weeks

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8
Q

Cimzia dosing on PP

A

400mg every 2 weeks (<90kg - 400mg week 0, 2, 4 then 200mg every 2 weeks)

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9
Q

Cimzia dosing on CD

A

400mg week 0, 2, 4 then 400mg every 4 weeks

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10
Q

Simponi dosing on RA/PsA/AS

A

50mg monthly (IV - 2mg/kg at week 0, 4, then every 8 weeks); for RA - with MTX

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11
Q

Simponi dosing on UC

A

200mg week 0 then 100mg week 2 then 100mg every 4 weeks

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12
Q

Remicade dosing on RA

A

3mg/kg at 0, 2 and 6 weeks then 3mg/kg q 8 weeks

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13
Q

Anakinra (Kineret) indication and dose

A

RA - 100mg SC QD

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14
Q

Rilonacept (Arcalyst) indication and dose

A

CAPS and recurrent peri-carditis - 320mg SC followed by 160mg weekly beginning 1 week later (>12 yo)

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15
Q

Canakinumab (Ilaris) indication and dose

A

CAPS, FMF, HIDS, MKD, TRAPS - 150mg SC every 8 weeks;

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16
Q

Dupilumab (Dupixent) indication and dose

A

AD, Prurigo Nodularis: 600mg initially then 300mg every other week
EOE: 300mg once weekly
note PFS approved for >6 months; Pen for >2yo

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17
Q

Tocilizumab (Actemra) indication and dose

A

RA - SC - <100kg - 162mg every other week; >100kg - 162mg weekly; (IV 4-8mg/kg every 4 weeks)
GCA, ILD - 162mg SC weekly

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18
Q

Sarilumab (Kevzara) indication and dose

A

RA and Polymaylaiga Rheumatica - 200mg SC every 2 weeks

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19
Q

Tralokinumab (Adbry) indication and dose

A

AD - 600mg (4x150mg) initially then 300mg (2x150mg) every other week (<100kg pt - can consider 300mg every 4 weeks for clear skin after 16wks of tx)

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20
Q

Secukinumab (Cosentyx) indication and dose

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A

PP - 300mg q wk for 5 weeks then 300mg every month
PsA/AS/nr-axSpA - 150mg q wk for 5 weeks then 150mg every month (LD is optional) - can increase to 300mg every 4 weeks

21
Q

Ixekizumab (Taltz) indication and dose

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A

AS/PsA - 160mg once then 80mg every 4 weeks
PP - 160mg once then 80mg week 2, 4, 6, 8, 10, 12 then 80mg every 8 weeks
nr-axSpA - 80mg every 4 weeks (no LD)

22
Q

Brodalumab (Siliq) - indication and dose

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A

PP - 210mg SC week 0, 1, 2 and then 210mg every 2 weeks

23
Q

Ustekinumab (Stelara) - indication and dose

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A

PP - <100kg - 45mg at week 0, 4, then every 12 weeks
>100kg - 90mg at week 0, 4, then every 12 weeks
PsA - 45mg at week 0, 4, then every 12 weeks
CD/UC - Induction IV then maintenance 90mg every 8 weeks begin 8 weeks after IV induction (single dose)

24
Q

Tildrakizumab (Ilumya) - indication and dose

Study These Flashcards
A

PP - 100mg week 0, 4, and q 12 weeks

25
Risankizumab (Skyrizi) - indication and dose
PsA and PP- 150mg at week 0, 4 and every 12 weeks CD - IV 600mg at week 0, 4, 8 then SC 180mg to 360mg SC at week 12 then every 8 weeks thereafter (Check liver enzyme and bilirubin before starting)
26
Guselkumab (Tremfya) - indication and dose
PsA and PP - 100mg week 0, 4, then every 8 wks
27
Spesolimab (Spevigo) - indication and dose
GPP (Generalized Pustular Psoriasis) - 900mg IV once if flare persists, additional 900mg may be given 1 wk later
28
Tofacitinib (Xeljanz) - indication and dose
RA, AS, PsA - 5mg BID or 11mg XR QD UC - IR induction 10mg BID x 8 wks then 5mg or 10mg BID or XR induction - 22mg dailyx8 wks then 11 or 22mg daily
29
Baricitinib (Olumiant) - indication and dose
RA - 2mg daily AA - 2mg daily may increase to 4mg if inadequate response
30
Upadacitinib (Rinvoq) - indication and dose
RA, PsA, AD, AS, NraxSPA - 15mg daily (may increase to 30mg in AD) UC and CD - 45mg daily for 8 to 12 wk then 15mg daily (may consider 30mg daily for extensive disease)
31
Abrocitinib (Cinbiqo) - indication and dose
AD- 100mg daily (if insufficient response after 12 weeks may increase to 200mg daily; start at 50mg if poor CYP2C19 metabolizer)
32
Ritlecitinib (Litfulo) - indication and dose
AA - >12 yo - 50mg po QD
33
Ruxolitinib (Opzelura) - indication and dose
AD - apply BID (should not exceed 20% BSA, reassess Tx if s/s not resolved within 8 weeks)
34
Deucravacitinib (Sotyktu) - indication and dose
PP - 6mg po daily
35
Abatacept (Orencia) - indication and dose
RA, PsA - 125mg SC weekly (+/- IV LD)
36
Apremilast (Otezla) - indication and dose
Bechets disease, PP, PsA - titration to 30mg BID starting with 10mg QAM
37
Belimumab (Benlysta) - indication and dose
SLE - IV 10mg/kg every 2 weeks x3 doses then 10mg/kg q 4 weeks SC 200mg once weekly (if switching from IV to SC - give SC dose 1-4 wks after last IV) Lupus Nephritis - IV - same with SLE SC - 400mg every week for 4 doses then 200mg every week thereafter
38
Vedolizumab (Entyvio)- indication and dose
CD/UC - 300mg IV at week 0, 2, and 6 then every 8 weeks
39
Natalizumab (Tysabri) indication and dose
CD - 300mg IV every 4 weeks
40
Rituximab (Rituxan) - indication and dose
RA - 1000mg IV days 1 and 15, then 1000mg every 16 to 24 weeks (Combo with MTX) Remphigus Vulgaris - 1000mg every 2 weks for 2 doses (in combo with glucocorticoids tapering) followed by maintenance of 500mg at months 12 and 18 and every 6 months
41
Pegloticase (Krystexxa) - indication and dose
Gout - 8 mg IV every 2 weeks (With MTX)
42
Omalizumab (Xolair)- indication and dose
Chronic idiopathic urticaria - 150mg or 300mg every 4 weeks
43
Methotrexate- indication and dose
RA and PP - 7.5mg - 25mg every week
44
Teduglutide (Gattex) - indication and dose
SBS (Short bowel syndrome) - 0.05mg/kg SC once daily
45
Ozanimod (Zeposia) - indication and dose
UC - titration from 0.23mg once daily to 0.92mg once daily starting on day 8 (if missed dose at first 2 weeks, reinititate titration with 0.23mg once daily)
46
Anifrolumab (Saphnelo) - indication and dose
SLE - 300mg IV every 4 weeks
47
Voclosporin (Lupkynis) - indication and dose
Lupus Nephritis - adjust dose with renal and hepatic impairment: Initial 23.7mg (3 capsules) BID +CS +MMF
48
Avacopan (Tavenos) - indication and dose
ANCA associated vasculitis (Adjunctive agent) - 30mg (3 capsules) po BID

Certificate of Specialty Pharmacy (3 decks)

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