Individual Chemo

Question 1

Alkylating Agent Chemo’s

Answer 1

Cell cycle NON-SPECIFIC
Cisplatin
Oxaliplatin
Carboplatin
BEndamustine
Cyclophosphamide
Ifosphamide
Melphalan
BEndamustine
Busulfan
Thitepa

Question 2

Antimetabolites- Antifolates chemo names

Answer 2

Methotrexate
Premetrexed
Pralatrexate

Question 3

5-Fluropyrimidines chemo names

Answer 3

Cell cell SPECIFIC
Flurouracil
Capecitabine
Flourdine

Question 4

Cytosine Analogues names

Answer 4

Cell cycle SPECIFIC
Azacitidine (Vidaza)
Decitabine
Cytarabine (ara-C)
Fludarabine
Gemcitabine

Question 5

Anthracyline and Antitumor antibiotic names

Answer 5

Cell cycle SPECIFIC
Doxorubicin
Epirubicin
Idarubicin
Mitoxantron
Belong in
Vixeos (liposomal daunorubicin and cytarabine)

Question 6

antimicrotubule chemo names

Answer 6

Vincristine
Vinblastine
Binorelbine
Vindesine
Paclitaxel
Docetaxel
Ixabepilone
Eribulin

Question 7

Topoisomerase Inhibitor names

Answer 7

Cell cycle SPECIFIC
Irinotecan
Toptecan
Etoposide (VP-16)

Question 8

Nitrosureas names

Answer 8

Cell cycle NON-SPECIFIC
Cross blood brain barrier

Carmustine
Lou stone
STreptozocin

Question 9

Cisplatin side effects

Answer 9

Ototoxicity

Renal toxicity

Question 10

Oxaliplatin side effects

Answer 10

Cold neuropathy

Question 11

Carboplatin side effects

Answer 11

Hypersensitivity reaction (7th dose)
- may see itching, palms/feet

Question 12

Cyclophosphamide and Ifosfamide side effects

Answer 12

Hemorrhagic cystitis - used Mensa (usually equal dose)

Question 13

Methotrexate side effects

Answer 13

Renal toxicity

High dose - requires leucovorin rescue

Question 14

Pralatrexate side effects

Answer 14

Need to administer folic acid, steroids and B12

Question 15

Flurouracil side effects

Answer 15

Angina

Question 16

Capecitabine side effects

Answer 16

Hand-foot syndrome

Question 17

Azacitidine side effects

Answer 17

(Vidaza)

CHF

Question 18

Decitabine side effects

Answer 18

TLS

Question 19

Cytarabine side effects

Answer 19

Cerebellar toxicity
High dose - conjunctivitis (use steroid eye drops)
Neurotoxicity

Question 20

Fludarabine side effects

Answer 20

TLS

Question 21

Gemcitabine side effects

Answer 21

Pulmonary toxicity

Question 22

Doxorubicin/Daunorubicin side effects

Answer 22

Cell cycle SPECIFIC
Lifetime cumulative dose
Radiation recall of XRT dermatitis
Red urine

Question 23

Liposomal doxorubicin side effects

Answer 23

Hand foot syndrome

Question 24

Epirubicin/Idarubicin side effects

Answer 24

Red urine

Question 25

Mitoxantrone side effects

Answer 25

Blue urine and sclera

Question 26

Bleomycin side effects

Answer 26

Pulmonary fibrosis

Question 27

Vyxeos (liposomal daunorubicin and cytarabine) side effects

Answer 27

Myelosupression Cardiotoxicity Hypersensitivity Copper overload

Question 28

Vincristine side effects

Answer 28

Cell cycle SPECIFIC FATAL if intrathecal Constipation

Question 29

Paclitaxel/Docetaxel side effects

Answer 29

Cell cycle SPECIFIC Vesicant Anaphylactic reactions (can be severe) Myalgia

Question 30

Irintoecan Side effects

Answer 30

Cell cycle specific Diarrhea (early and late) Give atropine for early onset Give Imodium for late diarrhea

Question 31

Etoposide side effects

Answer 31

Cell cycle specific | Hypotension - give over 60 min

Question 32

Asparaginase side-effects

Answer 32

``` Anaphylactic reactions Hepatotoxicity Coagulopathy Pancreatitis Cell cycle NON-SPECIFIC ```

Question 33

Treninoin (ATRA) and Arsenic side-effects

Answer 33

QT prolongation - could lead to Torsades Electrolyte imbalance Cough and dyspnea (retinoids acid syndrome) --white cells go to lungs - manage with steroids

Question 34

Hydrea side effects

Answer 34

bone marrow depression Mucositis Secondary malignancy

Question 35

Carmustine side effects

Answer 35

Cross blood brain barrier Part of BEAM regimen for lymphoma Pulmonary fibrosis

Question 36

STreptozocin side effects

Answer 36

Renal toxicity Bone marrow depression Hyperglycemia