infection and response Flashcards

1
Q

what are pathogens

A

microorganisms that can cause communicable diseases that effects plants and animals

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2
Q

how do pathogens spread and what type of diseases correlate with this

A

air - tiny droplets through air causing things like covid/ flu
contaminating food + water - causing things like salmonella and cholera
direct contact - walking barefoot on public surfaces such as athletes foot

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2
Q

what is a vector

A

organisms which carry pathogens

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2
Q

what are the four types of microorganisms

A

bacteria, virus, protist, fungi

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3
Q

how can diseases be prevented

A
  • being hygienic such as washing hands or cleaning chopping boards
  • kill the vectors
  • vaccinations
  • isolate/ quarantine the person who has the dieses
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4
Q

what are virus diseases

A
  • very small
  • can’t reproduce by themself yet when they enter another organisms cell they use it to replicate themselves. The cell eventually bursts and the virus spreads to other cells to go an invade.
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5
Q

what are the three types of viral diseases

A
  • measles
  • HIV
  • tobacco mosaic virus
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6
Q

how are measles spread, what are the symptoms, how can it be treated

A
  • spread by air, when an infected person coughs or sneezes.
  • red rash over body, fever symptoms.
  • can be fatal yet most people are vaccinated
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7
Q

how is HIV spread, what are the symptoms, how can it be treated

A
  • sexual contract or exchange of bodily fluids
  • fever, tiredness which the person then gets over and feel better. the virus still spreads inside body and leads to unusual infections or cancer (aids).
  • this used to be untreatable yet now a new drug ( antiretroviral) has been developed
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8
Q

what is tobacco mosaic virus, what does it effect, what are the symptoms, what does it do, how can it be treated

A
  • effects tomato plants and tobacco plants
  • discolours patches on leaves which effects photosynthesis meaning the plant cannot produce sugars for growth .
  • cannot be treated but removing infected plants so it cannot spread is a good alternative
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9
Q

what are bacterial diseases

A

single celled organisms that reproduce by themselves

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10
Q

what are the bacterial diseases

A

salmonella, gonorrhoea

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11
Q

what is salmonella, what are the symptoms, treated?

A
  • a type of food poisoning
  • stomach cramps, fever, …, diarrhoea
  • passes by itself after a week, stay hydrated
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12
Q

what is gonorrhoea, what are the symptoms, treatments, preventions

A
  • sexually transmitted disease - sexual contact
  • pain when urinating, thick yellow/green discharge
  • preventions - avoid unsafe sex use preventions
  • treatment - used to use penicillin but it is becoming more resistant so having to use more expensive rarer antibiotics
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13
Q

what is fungal disease, what are the symptoms, effect, treatments, how is it spread

A
  • rose black spot
  • causes black spots, turn the leaves yellow and they will drop off.
  • reduces photosynthesis and stops growth
  • spread by water and wind
  • chopping of infected leaves or spraying with fungicide
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14
Q

what is the protist disease, what are the symptoms, effect, treatments, how is it spread

A
  • malaria
  • transported by vector (mosquito) when mosquito sucks blood from one animal that is already infected, it takes blood and the parasite from the animal taking it to the other host infecting them
  • headaches, fevers
  • vaccinations, stop vectors first, mosquito repellent
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15
Q

what is a defence system and what are the two types

A

works to prevent pathogens from entering the body
- physical and chemical
- immune system

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16
Q

what are the different type of physical and chemical barriers and how do they help

A

skin - kills pathogens before they even enter the body
nose - lots of hair and mucus meaning it traps most pathogens
trachea - mucus meaning it traps pathogens
cilia - move pathogen filled mucus into the stomach - full of high acid hydrochloric acid which helps kills the pathogens

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17
Q

what is an immune system defence

A

when the pathogens get passed the physical and chemical defences, body’s immune system needs to step in

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18
Q

how do white blood cells help get rid of pathogens

A

phagocytosis - the process of engulfing pathogens to kill them
antitoxins - they neutralise the toxins released by the pathogens by binding to them
antibodies - act as a signal for white blood cells to destroy antigens

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19
Q

what are antibodies

A

each antigen has an antigen on their surface which has a complementary antibody it binds to. once antibodies bind to the pathogen it makes it easier for white blood cells to find them

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20
Q

how do antibodies help if you get the same disease again

A

the specific complementary antibody will be able to produce antibodies faster. the individual then won’t feel the symptoms of the disease and therefore become immune to the disease

21
Q

what do vaccinations do

A

allow you to become immune to a pathogen without actually catching the disease

22
Q

how do vaccinations work

A
  1. a vaccine contains weakened or deactivated pathogens. these won’t cause diseases
  2. because they are still the same antigens, our body still produces antibodies and therefore create immunity
23
what pathogens do vaccines work on
bacteria and viruses
24
what are the pros and cons of vaccines
pros - protect us from catching diseases - control of common diseases - prevent outbrake cons - don't always work - might not create full immunity to pathogens - can have bad reactions against vaccines such as swelling, fevers, seizures
25
what do painkillers do
relieve the symptoms, pathogens will still be there, doesn't kill them
26
what do antibiotics do
treat the disease (only kill bacteria), directly kill the bacteria or make it stop growing
27
why can't antibiotics kill viruses
- antibiotics are made specifically for bacteria. viruses are so different so antibiotics can't help - antibiotics wouldn't be able to find the virus without destroying our own cells
28
what are the problems about antibiotics
- loads of different antibiotics for different bacteria meaning doctors have to investigate what drug needs to be provided - antibiotic resistence
29
where were drugs originally discovered from
plants and microorganisms
30
what do drugs need to be tested for
toxicity, efficiency, dose levels
31
how are drugs tested
preclinical testing and clinical trials
32
what is preclinical testing
using cells, tissue, live animals
33
what are clinical trials and why do we use them
using volunteers and patients to test how well drugs work
34
how did researchers test how well drugs work
using placebo method. two groups, one given the actual drug and the over given the placebo. this tested how well the drug actually works
35
what is single-blind
only the doctors knows weather the patient is receiving the drug
36
what is double bind
neither the patient or doctor knows weather they are receiving drugs or not
37
how are drugs developed from plants
aspirin - developed from willow trees digitalis - developed from foxgloves - used to treat heart problems
38
how are drugs developed from microorganisms
developed by Alexander Fleming. found when he was growing bacteria on plate. He found mould was producing a substance called penicillin which kills bacteria
39
what are monoclonal antibodies
antibodies from a single clone of cell
40
where are they made
in a laboratory
41
how are monoclonal antibodies made
- need a lot of lymphocyte cells (white blood cells) - these don't divide very quickly so we combine with fast dividing tumour cells to for a hybridoma - these cells are then put into a periti dish where they then divide quickly. - we then collect these identical antibodies to purify them
42
how do we get the original lymphocytes
infect an animal ( such as a mouse) with the antigen we want the antibodies to bind to. this way we can easily isolate the lymphocytes and combine them with the tumour cells
43
how do monoclonal antibodies help destroy cells such as cancer cells
we can attach things ( such as drugs and radioactive materials) to the bottom of antibodies. these can then be used to deliver such things to cancer cells, when injected to a person. these then find these cells and destroy them
44
what are the advantages and disadvantages of monoclonal antibodies
pros - healthy cells aren't effected, develop many antibodies against many diseases cons - expensive, difficult to attach things to thee bottom of antibodies
45
what are the common signs of a plant disease
- stunted growth - spots on leaves - areas of decay - abnormal growth - discolouration - pests on leaves
46
how can you identify the disease of plants
using a gardening website identifying the pathogen by observing the infected plant in a lab use monoclonal antibodies to identify the pathogen trial and error - trying different things to resolve the problem of plant such as spaying with minerals to help deficiencies
47
what are the plant diseases
rose black spot (fungal disease), tobacco mosaic disease (viral disease), deficiency (missing out on essential minerals)
48
how are plant defences split
physical, mechanical and chemical
49
what are physical defences
physically preventing the entry of pathogens: - waxy cuticle - cellulose cell walls - layers of dead cells (such as bark)
50
what are chemical defences
actually chemicals that the plant can produce - anti microbial ( killing bacteria or fungi) - poisons that kill insects
51
what are mechanical defences
similar to physical yet have more of function - thorns - hairs to stop insects touching them - leaves that curl or droop if insects land on them
52