Infectious Flashcards
(219 cards)
What is the cause of Alice in Wonderland syndrome
EBV
metamorphosia, perceptual distortions of sizes, spatial relationships may be presenting symptoms
Malaria chemoprophylaxis
Doxycycline (100mg/tablet): 2mg/kg
start 2-3 days prior to travel up to 4 weeks upon leaving area
Mefloquine tab: >45kg = 250mg; <45kg=5mg/kg
1 week prior to travel up to 4 weeks
Chloroquine and Mefloquine: 1-2 weeks to 4 wks after
Doxycyline: 1-2 days prior to 4 weeks; not for <8yo
Atovaquone/Proguanil (malarone): 1-2 days to 7 days after
rectal temperature of 38C or higher as sole presenting feature
Fever without a focus
- neonates or infants to 1 month: fever who does not appear ill have 7% risk of having serious bacterial infection
- infants >1month to 3 months of age: pyelonephritis most common
- children >3moths to 3yrs: viral infections
What is fever of unknown origin
fever documented for which cause could not be identified after 3 weeks evaluation as outpatient or
after 1 week of evaluation in the hospital
connective tissue disease most commonly associated with FUO
SLE and JIA
most common cause of pyogenic infection of skin and soft tissue
Staphylococcus aureus
associated with invasive skin disease
PVL
most common cause of osteomyelitis and suppurative arthritis in children
Staphylococcus aureus
fever, hypotension, an erythematous rash with subsequent desquamation on the hands and feet, multisystem involvement including vomiting, diarrhea, myalgia, conjunctival hyperemia and strawberry tongue
Toxic shock syndrome
*many cases occur in women 15-25yo who use tampons
primary toxin is TSST-1
Toxic Shock syndrome
what are the major and minor criteria of Toxic Shock Syndrome
Major (all required):
Fever >38C
hypotension
rash (erythroderma with convalescent desquamation)
MInor (3 or more): mucuous membrane inflammation vomiting, diarrhea liver abnormalities renal abnormalities muscle abnormalities CNS abnormalities Thrombocytopenia
Treatment for toxic shock syndrome
Beta lactamase antistphyloccocal: Nafcillin and Oxacillin or 1st Gen Cephalosporins
MRSA: Vancomycin
What are coagulase negative staphyloccoci?
S. epidermidis
S. pyogenes
S. saphrophyticus
Treatment of choice for CONS
Vancomycin
most common cause of nosocomial bacteremia associated with central venous catheters
S. epidermidis
associated with CSF shunt meningitis
CONS
What is true bacteremia
blood cultures grow rapidly (within 24hr)
>/= 2 blood cultures are positive with same CONS
clinical signs and symptoms compatible with CONS sepsis
most common cause of bacteremia, bacterial pneumonia and otitis media
Streptococcus pneumoniae
when do we use a D test?
in cases where pneumococcus is resistant to erythromycin but sensitive to clindamycin
D test should be performed to determine whether clindamycin resistance can be induced
If positive D test, clindamycin should not be used
Drug of choice for Streptococcus pyogenes
Penicillin G
virulence of Group A Strep
M protein
gold standard for documentation of presence of GAS
throat culture
in patients who do not fulfill Jones criteria but had acute onset of arthritis following episode of GAS infection
Poststreptococcal reactive arthritis
Not migratory
does not respond dramatically to therapy with Aspirin and other NSAIDS
role of secondary prophylaxis not established
PANDAS is associated with
GAS infection