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Infectious Disease 2 Flashcards

(51 cards)

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1
Q

Bacteria characteristics

A

single celled

well defined walls

no true nuclear membrane

grow independently but require nourishing medium to maintain fxn

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2
Q

Bacteria classification

A

shape
- spherical = cocci
- rod = bacilli
- spiral = spirilla or spirochetes

response to staining
motility
capsulation
capacity to form spores
aerobic or anaerobic

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3
Q

Pathogenic effects of Bacteria (how do they harm?)

A

bacteria multiply and compete with host cells for essential nutrients

may directly harm human cells by releasing toxic substances

may cause an immune response that will damage human tissues along with the bacteria

not all bacteria is harmful

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4
Q

Bacterial infections examples

A

Enterobacteriaceae

C diff

staph

strep

clostridial myonecrosis

pseudomonas

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5
Q

Clostridiomes (clostridium) Difficle (CDI) or C. Diff

A

diarrhea after antibiotic consumption

GI system

transmission of C. diff is through fecal-oral route (poopy hands to another person who then eats)

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6
Q

Staphylococcal infections

A

People with chronic skin lesions and surgical and burn patients

Infections of burns, surgical wounds, bacterial arthritis, food positioning

Integumentary system

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7
Q

Streptococcal infections

A

strep throat

multiple versions target different organ systems
- Groups A; respiratory droplets
- Group B (GBS) - neonatal pneumonia, meningitis, and sepsis

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8
Q

Clostridial Myonecrosis (GAS Gangrene)

Types

A

Gangrene is death of body tissue usually associated with loss of vascular supply abd then bacterial invasion and putrefaction

3 types; dry, moist and gas

anaerobic conditions

integumentary system

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9
Q

What causes dry, moist and gas gangrene

A

dry and moist - loss of blood circulation due to various causes

gas - occurs in wounds infected by anaerobic bacteria, leading to gas production and tissue breakdown

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10
Q

Pseudomonas

A

most common in hospital and nursing home - acquired pathogens

integumentary, circulatory and respiratory systems

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11
Q

How do you select an antibacterial drug?

A

broad-spectrum (when pathogen is unknown) vs specific agents

other factors such as patient tolerance, bacterial resistance, and doctor preference

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12
Q

Bactericidal vs Bacteriostatic activity

A

Bactericidal - drugs that kill or destroy bacteria

Bacteriostatic - drugs that do not kill but limit the growth and proliferation of bacteria

classification may depend on drug dosage

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13
Q

Describe the basic mechanisms of antibacterial drugs

A
  1. inhibition of bacterial cell wall synthesis and function
  2. inhibition of bacterial protein synthesis
  3. inhibition of bacterial DNA/RNA synthesis and function
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14
Q

How do antibacterial drugs cause inhibition of bacteria cell wall synthesis?

A

Bacteria have a rigid and firm cell wall made of peptidoglycans

Antibacterial drugs can cause inadequate production of peptidoglycans or other structural components of the wall

some drugs punch holes in the cell membrane, destroying selective permeability

some drugs act as DETERGENTS that break apart phospholipid bilayer, creating gaps and leakage

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15
Q

Antibacterial drugs inhibiting bacterial protein synthesis

A

antibacterial drugs enter and bind to ribosomal subunits of bacteria

binding blocks protein synthesis or causes mis reading

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16
Q

Antibacterial inhibition of RNA/DNA synthesis

A

FOLIC acid serves as an enzymatic cofactor in several reactions, including the synthesis of bacterial nucleic acids and certain essential amino acids

drugs inhibit bacterial nucleic acid synthesis by inhabiting the production of folic acid

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17
Q

How does resistance to antibacterial drugs occur?

A

certain bacterial strains have a natural or acquired defense mechanism against specific anti-bacterial drugs, which enables the strain to survive the effects of the drug and continue to grow and reproduce similar resistant strains, representing a gene etic selection process in which only the resistant strain survives

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18
Q

How do we control the problem of bacterial resistance?

A

antibiotic stewardship (used carefully and not overused)

identify specific pathogenic bacteria and administer selective agents over broad agents to kill resistant strains more effectively

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19
Q

Common side effects of antibacterial drugs

A

hypersensitivty reactions (skin rashes, itching, wheezing)

GI problems

can interrupt therapy

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20
Q

Virus characteristics

A

subcellular organisms made up of only an RNA or DNA nucleus covered with proteins

smallest known organisms

completely dependent on host cells to replicate

not susceptible to antibiotics

antiviral meds can moderate the course of the viral illness

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21
Q

Hep A virus family

Study These Flashcards
A

Picornavirdae

22
Q

Heb B virus family

23
Q

Hep C virus family

24
Q

Chicken pox virus family

Study These Flashcards
A

Herpesviridae

25
Herpes virus family
herpesviridae
26
Influenza virus family
Orthomyxoviridae
27
Corona virus family
cornaviridae
28
What happens during viral replication
virus often incapacitates the infected cell so that the infected cell cannot carry out its normal physiological activities antiviral drugs can interrupt the process of viral replication
29
What happens after viral replication?
Virus can leave via exocytosis, leaving host cell intact (but still infected with the original virus) OR it can destroy (lysis) the host cell, releasing viral offspring (which may result in inflammatory mediators and hypersensitivity response)
30
Examples of viral infections
bloodborne (HBV, HCV HIV) Herpes viruses Viral respiratory infections (flu and covid)
31
Bloodborne viral infections implications for therapists
Hep B transmitted to HCW via percutaneous injuries or by direct or indirect contact with blood, pre-exposure vaccine is recommended Hep C - accidental percutaneous injuries (needle sticks) are highest risk vehicle for transmission
32
Incubation period for Hep C (HVC)
6-7 weeks, nearly all who have acute infection will develop chronic (75% of people) no vaccine so handwashing to prevent transmission is critical
33
How many types of herpes are there
8
34
herpes incidence
approx 70% over 12 have herpes 1 20% over 12 have 2 if mom has genital herpes the baby can get it during delivery
35
Pathogenesis of herpes
primary infection occurs through a break in the mucos membranes of mouth, throat, eye, genitals or via minor abrasions on the skin local multiplication iccurs followed by viremia and systemic infection with a subsequent latent infection and periodic reactivation of the virus (like via stress)
36
Clinical manifestations of herpes
HSV 1 typically occurs around mouth and oral cavity causing vesicles in the mouth, throat and around lips primary HSV 2 - vesicles form in the genitourinary tract primary symptoms can be asymptomatic systemic symptoms - headache, malaise, myalgias and fever
37
How is HSV 2 acquired
sexual contact
38
What type of herpes is very contagious?
Type 3 Varicella zoster period of communicability extends from 1-2 days before the onset of the rash through the first 4-5 days or until all lesions have formed crusts
39
What is Herpes virus type 3 known as
chicken pox or shingles older adults above 50 who are immunocompromised are at higher risk
40
Herpes type 4
Epstein-Barr virus primarily affects young adults and children transmitted through oral secretions, blood or transplanted organs with the virus common in US with 95% of people between n35-40 having been infected when infected with EBV, 35-50% chance it will become mononucleosis
41
Herpes type 4 Monocucleosis implications
probably contagious before symptoms develop person infected should avoid excessive activity and contact sports for at least 1 month
42
RSV
causes annual breakouts of pneumonia, brohncitis, tracheoobroncitis in infants and young children, main cause of hospitilization
43
How long do people shed RSV?
3-8 days, infants may shed up to 3-4 weeks
44
How is RSV diagnosed
rapid diagnosis via viral antigen idenification of nasal washings using ELISA or IFA
45
Treatment of RSV
hydration, humidification of inspired air, ventilatory support as needed
46
Flu season an transmission
late fall to early spring person to person by inhalation of aerosolized virus or direct contact
47
Flu onset and fever duration
onset is abrupt, higher fever and chills, malaise, muscular aching, headache, sore throat and nasal congestion and nonproductive cough fever lasts 1-7 days (usually 3-5)
48
How can the flu virus progress
can progress rapidly in first few days causing pneumonia and respiratory failure particularly in high risk groups secondary bacterial pneumonia may also develop in 5-10 days after the onset in the older adult
49
Viral resistance
viruses can mutate and alter their structural or functional characteristics so that previously effective drugs will be unable to control specific viral infections adequately limit inappropriate use of antiviral drugs
50
Interferons
endogenous substances that exert nonspecific antiviral activity proteins that are made by the infected cell in response to viral infection enable healthy cells to resist infection from a wide array of viruses
51
types of interferons
type 1 - alpha and beta type 2 - gamma type 3 - lambda

Internal Med (26 decks)

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