Infectious Disease

Question 1

What are the symptoms of tabes dorsalis?

Answer 1

Chronic dorsal column degradation with LMNL signs and paraesthesia, proprioceptive loss
High stepping ‘tabetic’ gait

Question 2

What are the non-peripheral neuropathy signs of tertiary syphilis?

Answer 2

Personality change/psychiatric disturbance
Dementia
Urinary incontinence
Hearing loss and visual impairment; Argyll Robertson pupil
Romberg test positivity

Question 3

What is tabes dorsalgia?

Answer 3

Back pain associated with tertiary syphilis

Question 4

What are the characteristic signs of zika virus congenital infection?

Answer 4

Large occipital bone outgrowth
Microcephaly
Cerebral calcifications

Question 5

Discuss flavivirus immunity and reinfection?

Answer 5

Previous dengue/chikungunya/zika infection conveys IgG immunity, which can worsen subsequent infections through serological cross reactivity and Ab dependent enhancement of infection

Question 6

What imaging signs suggest CNS toxoplasmosis?

Answer 6

Hypodense lesions on CT which ring enhance around edges with contrast