Infectious DIsease Flashcards
(106 cards)
1
Q
Transmission of virus from same species
A
Antigenic drift
2
Q
Transmission from different species
A
Antigenic shift
3
Q
B-cell deficiency
A
Bruton X Linked agammaglobulinemia
4
Q
Viruses infect certain cells and not others. What mechanism of viral injury?
A
Tissue tropism
5
Q
Clustered virulence genes in the microbe genome
A
Pathogenicity islands
6
Q
Agent of measles
A
Rubeola
7
Q
Virus with direct cytopathic effects
A
HPV
8
Q
Autoinducer peptides are secreted for expression of virulence factors in large population
A
Quorum sensing
9
Q
N. Gonorrheae escapes immune clearance because of what?
A
Pilus variation
10
Q
Causative agent of donovanosis
A
K. Granulomatis
11
Q
Causative agent of LGV
A
C. Trachomatis
12
Q
First step in infection
A
Binding to specific cells or matrix/ with used of Adhesins
13
Q
Type of inflammation with increased vascular permeability and Neutrophil infiltration
A
Suppurative or Purulent Inflammation
14
Q
Type of inflammation with accumulation of activated macrophages
A
Granulomatous inflammation
15
Q
Venereal warts, what agent?
A
HPV
16
Q
Cell wall component of Gm (-) bacteria
A
Lipopolysaccharide
17
Q
Total destructionof temporal lobes of brain. What virus?
A
Herpes virus
18
Q
Acid fast stain bacteria
A
Mycobacteria, nocardia
19
Q
Can be stained by silver stain
A
Fungi, legionella, pneumocystis
20
Q
Stained by mucicarmine
A
Crytococcus
21
Q
Most common extrasalivary gland complication
A
Aseptic meningitis
22
Q
Stained by giemsa
A
Camplybacter, leishmaniae, malaria parasites
23
Q
Leading cause of vaccine-preventable morbidity and mortality
A
Rubeola
24
Q
Pathognomonic sign of measles
A
Koplik spots
25
Ulcerated mucosal lesions near opening of stensen ducts
Koplik spots
26
Multinucleated giant cells with eosinophilic inclusion bodies?
What virus?
Warthin-finkeldey cells/ Rubeola
27
Causative agent of exanthem subitum
HHV-6
28
Poliovirus infecs by binding to what receptor?
CD155
29
Late complications of measles
Subacute Sclerosing Panencephalitis
| Inclusion body encephalitis
30
When poliovirus replicate in motor neuron of spinal cord, it causes what?
Muscular paralysis
31
Major reservoir of West Nile virus
Birds
32
Causative agent of Viral Hemorrhagic fevers
Ebola, Lassa, Marburg
33
Causative agent of Kaposis sarcoma
HHV-8
34
Major infectious cause of corneal blindness
HSV-1
35
Major cause of sporadic encephalitis
HSV-1
36
Swollen erythematous lesion on fingers and palms of infants and healthcare workers caused by HSV
Herpetic whitlow
37
When poliovirus replicate on brain stem, it causes what?
Bulbar poliomyelitis
38
Causative agent of kaposi varicelliform eruption
HSV
39
Generalized vesiculating involvment of skin caused by HSV
Kaposi varicelliform eruption
40
Causative agent of eczema herpeticum
HSV
41
Other name of exanthem subitum
Roseola infantum, 6th disease
42
What do you call the hemorrhagic rashes in malnourished children?
Black measles
43
Large, pink to purple intranuclear inclusion in HSVq
Cowdry type A
44
Large inclusion surrounded by halo w/in nucleus of CMV
Owl;s eye
45
Causative agent of chicken pox
Varicella
46
VZV establishes latent infection where?
Sensory ganglia (Dorsal root ganglia)
47
Disease with macule or vesicle like dewdrop on a rose petal
Chicken pox
48
Chronic suppurative infection of apocrine glands of axilla is called what? Caused by?
Hidradenitis/ S. aureus
49
Facial paralysis due to geniculate nucleus involvement casued by VZV
Ramsay-hunt syndromne
50
Causative agent of infectious mononucleosis-like illness
CMV
51
Most common opportunistic viral pathogens in AIDS
Cmv
52
Skin infections caused by S aureus centered around hair follicles except what?
Impetigo: restricted to superficial epidermis
53
Causative agent of infectious mononucleosis
EBV
54
EBV establishes latency where?
B-cells
55
EBV can cause what cancer?
Burkitt lmyphoma
56
Opportunistic infection in catheterized px or px with prosthetic cardiac valves
S. Epidermidis
57
S. Aureus has surface receptors for fibrinogen called?
Clumping factor
58
S. Aureus toxin that is pore forming protein
a-toxin
59
Toxins of S aureus causing SSSS
Exfoliative A & B toxins
60
CMV latenly infects what?
Monocytes and BM progenitors
61
Exfoliative toxins are serine protease that degrades what?
Desmoglein-1
62
Infxs of palmar side of fingertips caused by S aureus
Felon
63
Other name SSSS
Ritter disease
64
Ritter disease is the caused of desquamation of what layer of skin
Granulosa layer
65
Other name of Lyell's disease
Toxic epidermal necrolysis: desquam at epidermal-dermal junction
66
Post-infectious syndromes of Strep
Rheumatic fever
Immune complex glomerulonephritis
Erythema nodosum
67
B-hemolytic strep
S pyogenes
| S agalactiae
68
Causative agent of erysipelas in human
S pyogenes
69
Common cause of community acquired pneumonia
S pneumoniae
70
Hyperkeratosis and scaling of skin during defervescense.what disease?
Scarlet fever
72
Common cause of endocarditis
Strep viridans
73
Major cause of dental caries
S mutans
74
Causative agent of rapid progressing necrotizing fasciitis
S pyogenes
75
Most important virulence factor of S pneumoniae
Capsule
76
Important cause of lobar pneumonia
S pneumoniae
77
Rapidly spreading erythematous cutaneous swelling begin on the face, sometimes body or extremity caused by S pyogenes
Erysipelas
78
Major antecendent of PSGN
Streptococcal pharyngitis
79
Disseminated disease in neonates caused by L monocytogenes
Granulomatosis infanseptica
80
Caused of Scarlet Fever
S pyogenes
81
Only one toxin of C diptheriae
Phage encoded A-B toxin
82
Action of phage encoded A-B toxin
Blocks host cell protein synthesis
83
Causative agent of pseudomembrane
C diptheriae
84
Spore forming bacteria
Bacillus
| Clostridium
85
Antiphagocytic factor of Bacillus anthrax
Polyglutamyl capsule
86
What is black eschar?
Cutaneous anthrax
87
Causative agent of Black eschar
Bacillus anthrax
88
Large, box-car-shaped gram (+) extracellular bacterial in chains
Bacillus anthracis
89
Causative agent of bacterial meningitis in children younger than 2 years
Neisseria meningitides
90
2nd most common sexually transmitted bacterial infection
Neisseria
91
Leading cause of sexually transmitted bacterial infection
Chlamydia
92
Virulence factors of Neisseria that inhibit opsonization
Capsule
93
Bacteria with OPA proteins
Neisseria
94
Agent of whooping cough
Bordetella pertussis
95
Agent of corneal keratitis and swimmer's ear
P aeruginosa
96
Agent of ecthyema gangrenosum
P aeruginosa
97
Virulence factors of P aeruginosa that inhibits protein synthesis
Exotoxin A
98
Action of Elastase of P aeruginosa
Degrades IgG and ECM
99
In cystic fibrosis, P aeruginosa secretes what to form slimy biofilm
Alginate (exopolysaccharide)
100
Agent of Black plague
Yersinia pestis
101
Agent of Chanchroid or soft chancre
H ducreyi
102
H ducreyi ulcers serve as cofactors of transmission of what?
HIV
103
2nd leading infectious cause of death worldwide
MTB
104
Leading infectious cause of death worldwide
HIV
105
Toxin secreted by M tuberculosis
No toxins
106
Virulence of M tuberculosis is based on what?
Cell wall properties (mycolic acid)
107
Causative agent of granulomatosis infanseptica
L monocytogenes
