Infectious Disease

Question 1

Adverse effects of Linezolid?

Answer 1

thrombocytopenia, interaction with MAOI

Question 2

Adverse effects of Tigecycline?

Answer 2

Just don’t use them for MRSA bacteremia

Question 3

Adverse effects of Daptomycin?

Answer 3

CPK elevation, not effective in the lung

Question 4

Drugs used to treat minor MRSA infections of the skin?

Answer 4

TMP/SMX, doxycycline, clindamycin, linezolid

Question 5

Bacteria covered by amoxicillin?

Answer 5

HELPS

H. influenzae

E. coli

Listeria

Proteus

Salmonella

Question 6

Amoxicillin is best initial therapy for what?

Answer 6

otitis media

dental infection/endocarditis prophylaxis

lyme dz limited to rash, joint, or 7th CN

UTI in pregnancy women

listeria monocytogenes

enterococcal infections

Question 7

Which antibiotic should be avoided in neonates due to impaired biliary metabolism?

Answer 7

ceftriaxone

Question 8

Adverse effects of cephalosporins?

Answer 8

Cefoxitin and cefotetan deplete prothrombin and increase risk of bleeding.

with ceftriaxone, there is inadequate biliary metablism.

Question 9

Adverse reaction of quinolones?

Answer 9

Bone growth abnormalities in children and pregnant women.

Tendonitis and achilles tendon rupture.

Question 10

Adverse reaction to aminoglycosides?

Answer 10

Nephrotoxic and ototoxic

Question 11

Adverse reaction to TMP/SMX?

Answer 11

Rash

hemolysis with G6PD deficiency

bone marrow suppression (folate antagonist)

Question 12

Most common microbes for meningitis?

Answer 12

Streptococcus pneumonia (60%)

Neisseria meningititis (15%)

group b streptococci (14%)

H. influenzae (7%)

Listeria (2%)

Stapholococcus in those with recent surgery

Question 13

For meningitis: Most likely dx with AIDS with <100 CD4+ count?

Answer 13

cryptococcus

Question 14

For meningitis: Most likely dx with camper/hiker, rash shaped like a target, joint paint, facial palsy, tick remembered in 20%?

Answer 14

lyme disease

Question 15

For meningitis: Most likely dx with camper/hiker, rash moves from arms/legs to trunk, tick remembered in 60%?

Answer 15

rocky mountain spotted fever (rickettsia)

Question 16

For meningitis: Most likely dx with pulmonary TB in 85%?

Answer 16

Tuberculosis

Question 17

For meningitis: Most likely dx with adolescent, petechial rash?

Answer 17

Neisseria

Question 18

For meningitis: with no presentation?

Answer 18

viral

Question 19

which drugs to use if LP shows thousands of PMNs?

Answer 19

ceftriaxone and vancomycin and steroids

If listeria is a concern, add ampicillin

(for listeria, concern with elderly, neonates, steroid use, aids or HIV, immunocompromised, including alcohol, pregnant)

Question 20

HIV patients CD4+ < 200

Answer 20

PCP

also increased risk for VZV, HSV, TB, candiasis, Bacterial PNA, Kaposa Sarcoma

Question 21

adverse effect for zidovudine?

Answer 21

anemia

Question 22

adverse effect for stavudine and didanosine?

Answer 22

peripheral neuropathy and pancreatitis

Question 23

adverse effect for abacavir (HLA B5701)?

Answer 23

hypersentivity, stevens-johnsons reaction

Question 24

adverse effect for protease inhibitors?

Answer 24

HLD, hyperglycemia

Question 25

adverse effect for indinavir?

Answer 25

neprholithiasis

Question 26

adverse effect for tenofovir, disoproxil?

Answer 26

renal insufficiency, bone demineralization

Question 27

Spore from hot, dry areas like deserts, valley fever, joint pain, erythema nodosum

Answer 27

Coccidioidomycosis

Question 28

Coccidioidomycosis

Answer 28

Spore from hot, dry areas like deserts, valley fever, joint pain, erythema nodosum

Question 29

Spore moist soil with bird bat feces (rivers caves valleys), resembkles TB lung cavities, pancytopenia (plus spleen and LNs). Use urine and serum antigen tests.

Answer 29

Histoplasmosis

Question 30

Histoplasmosis

Answer 30

Spore moist soil with bird bat feces (rivers caves valleys), resembkles TB lung cavities, pancytopenia (plus spleen and LNs). Use urine and serum antigen tests.

Question 31

Spore found in soil and rotten wood near water. Involves lungs, bone, skin, prostate. Broad budding yeast on smear.

Answer 31

Blastomycosis

Question 32

Blastomycosis

Answer 32

Spore found in soil and rotten wood near water. Involves lungs, bone, skin, prostate. Broad budding yeast on smear.