Infectious disease Epidemics Flashcards

(52 cards)

1
Q

how do you define infection

A

Infection is the infiltration of body tissue by micro- organisms (or microbes) that may cause disease, followed by the multiplication of these micro-organisms

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2
Q

How do you define microorganism

A

A micro-organism that can cause disease is called a pathogen

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3
Q

How do you define contagious

A
  • derived from the word contact and describes infections that are transmissible person to person and thus this can also be termed communicable
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4
Q

Whats another word for contagious

A
  • Communicable
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5
Q

virtually all viral diseases are

A

virtually all viral diseases are caused by viruses that are communicable

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6
Q

How can you prevent trachoma

A

clean water and sanitation

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7
Q

What is the commonest cause of blindness

A

Trachoma

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8
Q

name the types of pathogens

A
  • viruses
  • bacteria
  • fungi, protozoa, worms
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9
Q

What are the two types of pathogens

A
  • opportunistic pathogens

- obligate pathogens

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10
Q

What is an opportunistic pathogen

A

Micro-organisms found in healthy host animals that may cause disease in certain circumstances, they take advantage of an “opportunity” not normally available

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11
Q

give examples of opportunistic pathogens

A

Commensals (staphylococcus, streptococcus)

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12
Q

describe opportunistic pathogens

A
  • Cannot infect healthy people (nor do they need to)
  • do so only when illness or injury introduces them to normally sterile parts of the body
  • do not make infected people infectious to other healthy people
  • do not cause epidemics
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13
Q

describe obligate pathogens

A
  • have no reservoir
  • must cause disease to be transmitted from one host to another
  • organisms with no environmental reservoir
  • do infect healthy people - they need to for their own survival
  • make infected people infectious to others - need to for their survival
  • introduced into a susceptible population and will spread from person to person and cause an epidemic
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14
Q

Name the animal sources of human pathogens

  • measles
  • smallpox
  • coronavirus
  • influenza
  • tuberculosis
  • herpes
  • hepaitits B
  • HIV
  • ebola
A
  • measles = dogs, cattle
  • smallpox = cattle (cowpox)
  • coronavirus = cattle, poultry
  • influenza = chickens, swine
  • tuberculosis = cattle (bovine TB)
  • herpes = Monkeys
  • hepaitits B = monkeys
  • HIV = chimpanzees
  • ebola = fruit bats
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15
Q

name some human pathogens that have derived from other human pathogens

A
  • syphilis from bejel

- leprosy from TB

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16
Q

What has caused the pathogens to spread around the world

A
  • human migration carried the organisms around the world
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17
Q

for organisms to survive in the short term what must it do

A
  • cause mild symptoms that will propagate the organism to other humans
  • not to kill humans or make them very ill
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18
Q

Why is it in the interests of the human to develop the symptoms (coughing & sneezing or diarrhoea?)

A
  • To dump live organisms from the body (help out the immune system)
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19
Q

describe examples of conditions that spread by respiratory means

A
  • Measles
  • TB
  • Influenza
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20
Q

What casues respriatory illnesses to spread

A
  • sneezing
  • coughing
  • over-crowding
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21
Q

what illnesses spread by faecal-oral transmission

A
  • polio
  • H pylori
  • rotavirus
  • cholera
22
Q

what casues spread of faecal oral transmission

A
  • Poor sanitation
23
Q

what illnesses spread by sexual transmission

A
  • HPV

- Chlamydia

24
Q

What casues illnesses to sprad by sexual tranmsission

A
  • mutiple partners

- failure to use a condom

25
what illnesses spread by insect vector
- Malaria - yellow fever - lyme disease
26
What casues illnesses to spread by insect vector
- bare skin
27
what strategies do organisms use to survive in the long term
- continue to infect one susceptible person after another - reinfect the same humans by changing its surface antigens so the IgG fails to recognise it - find a safe haven in our body - area not accessed by the immune system
28
List organsims that find a safe haven
- Varicella - Tubercle - Helicobacter pylori - typhoid fever
29
hygiene prevents
spread of the virus
30
What poeple get post-primary TB
Immunocompromised - alcoholics - homeless - old men
31
what diseases are protective of malaria
- sickle cell disease - thalassaemia - cystic firbosis
32
What is the differnet between the epidemics and endemics
Epidemics - goes through the community - but after a few waves everyone has been infected and it will die out Endemics - infects people slow - goes on for longer peroids of time - matches the birth rate
33
organisms with no environemental reservoir must...
Organisms with no environmental reservoir must infect healthy people, and characteristically do so in epidemics rather than sporadically
34
What are the determinants of the risk of an outbreak in a community
- Susceptible population - induction of organsims into community - spread fo organisms in the community
35
Name the cholera statistics
- 4 million cases | - 100,000 deaths
36
What are the principles of management of cholera outbreaks
- Clean water - boiled, bottled or chlorinated - beware of food washed in water - safe disposal of faeces
37
what can increase the severity of the epidemic
- major epidemics of severe illness are generally caused by organisms that are new to the community - age - nutritional status - infecting dose
38
List the major influenza outbreaks
- 1847 - H1N1 - 1889-90 - H2N2 - 1899-1900 - Russian - H3N2 - 1918-20 - Spanish - H1N1 - 40 million dead - 1957-60 - Asian - H2N2 - 1968-72 - Hong Kong - H3N2
39
What is the survival rate of ebola
- 70% with good supportive care (especially IV fluids) but much lower in malnourished people wihtout good care
40
What organism called the bubonic plague
- Yersinia Pestis | - humans contract it from the bites of infected fleas, the fleas live in the fur of the rats
41
describe how EBV is differnet in children and adults
* commonly asymptomatic in children * can be debilitating in teenagers and young adults (glandular fever) * Contracting the infection in teenage/young adult years may lead to multiple sclerosis
42
the symtpoms that follow an infection...
The symptoms that follow an infection are often caused not directly by the organism but by the host response - e.g. cytokines (host derived peptides released in response to a wide variety of stimuli)
43
Why is case severity greater on average during an epidemic that from sporadic cases
- because during an epidemic a person is oftne infected by two or more people so the infecting dose is greater
44
What cancers can HPV cause
- cervical cancer, | - anal cancer
45
What cancers can EBV cause
- nasopharyngeal cancer, - Burkitt’s lymphoma | - Hodgkin’s lymphoma
46
What cancer can HTLV cause
- T cell leukaemia
47
What cancer can cause Kaposi's sarcoma virus and associated herpes virus
Kaposi’s sarcoma
48
What cancer can cause Helicobacter pylori
Stomach cancer
49
what cancer can schistosomiasis cause
- Bladder cancer
50
What cancer can hepatitis B and C cause
- Liver cancer
51
Why is there a higher incidence in developing countries of epidemics
* Poor sanitation * Overcrowding * Parasites (and mosquitoes) thrive in tropical climates * Limited vaccination
52
Why is the case severity worse in developing countries
- Malnutrition - overcrowding - high infection dose - communal life style - infants under 1 year infected - genetic factors in some areas