Infectious Diseases I: Aminoglycosides Flashcards Preview

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Flashcards in Infectious Diseases I: Aminoglycosides Deck (18)
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1
Q

AG MOA

A

Bind to ribosome and inhibit protein synthesis of bacterial cells

2
Q

AG have what type of killing

A

concentration-dependent

3
Q

AG have a post-antibiotic effect (t/f)

A

True

Continued suppression of bacterial growth when antibiotic levels fall below MIC

4
Q

Extended interval dosing is beneficial bc…

A

it decr nephrotoxitiy and cost

has NOT shown to be clinically superior to traditional dosing

5
Q

AG coverage

A

mostly gram - (includ. pseudomonas)

used for synergy for treating gram + cocci (strep, entercoccus)

6
Q

AG side effects

A

nephrotoxicty
ototoxicity
vestibular toxicity (balance issues)

7
Q

If a pt is underweight use ____ to dose AGs

A

actual body weight

8
Q

If a pt is overweight use ____ to dose AGs

A

adjusted body weight

9
Q

Traditional dose of gentamicin and tobramycin

A

1-2.5 mg/kg/dose
lower for synergy w/ gram +
higher for gram - infection

10
Q

Extended interval dosing for gent/tobra

A

4-7 mg/kg/dose

11
Q

Dosing for amikacin

A

5-7 mg/kg/dose

12
Q

Contraindications for using extended interval dosing

A
pregnancy
ascites
burns
CF
CRcl < 30
ESRD
13
Q

What nomogram is commonly used for extended interval dosing?

A

Hartford nomogram

determines dosing interval based on concentration of random level

14
Q

Target peak concentrations for gent/tobra

A

5-10 mcg/ml

15
Q

Target trough conc for gent/tobra

A

< 2 mcg/ml

16
Q

Target peak and trough conc for synergy dosing of gent

A

peak: 3-4 mcg/ml
trough: < 1 mch/ml

17
Q

Target peak conc for amikacin

A

20-30 mcg/ml

18
Q

target trough conc for amikacin

A

< 5 mcg/ml

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