Infectious mononucleosis- P Flashcards
(12 cards)
EBV and less commonly CMV cause what dz, AKA kissing dz?
Infectious mononucleosis
IM cause lymphocytic leukocytosis of what particular cell and in what age group of people?
CD8+ T cells
Teens
EBV primarily infects what areas or cells?
- Oropharnx–> pharngitis
- Liver–> hepatomegaly with hepatitis–> means elevated liver enzymes
- B cells
Increase in CD8+ T-cells leads to what clinical findings?
- LAD
- Splenomegaly
- Lymphocytic leukocytosis= high WBC–> see atypical cells
How would increase in CD8+ T cells found in serum cause LAD?
T cell hyperplasia in the LN
- Paracortex
What happens in the cortex of the LN?
B- cell proliferation
How does T cell hyperplasia cause splenomegaly? Where in the spleen is this found?
Hyperplasia in the Periarterial lymphatic sheath (PALS)
- White pulp is where its found
- dense blue hue around arteries of spleen
How does the monospot test work and what is it used to screen? Timeline for best outcome?
Screens for mono
- Detects IgM Ab’s that cross react with horse of sheep RBCs
- after 1 week of infection
- negative test suggest CMV
What are heterophile Ab’s?
other loving
- Our Ab’s bind to cells of another animal at high affinity
The monospot test is a screening test. Is this definitive? If not what test is definitive for EBV IM?
No its just a screen
- Dx–> serologic testing for EBV viral capsid Ag
Im purposes some complications. What should be warning our patients about after leaving the clinic?
- Increase risk for splenic rupture- no contact sports for 1 MONTH
- Rash if taking cilins
- Lays dormant in B cells
EBV dormancy in B cells increases risk of what? What dz in particular can make an individual extremely susceptible?
Recurrence and B cell lymphoma
- immunodeficient individuals (HIV)
