Inflammation Flashcards
(21 cards)
What is the role of tissue inflammation
What is Acute inflammation?
Acute inflammation is characterised by …………….. signs
List them
Rubor
Calor
Dolor
Tumour
Laesa
What is the major aim of inflammation
To get rid of an offender in the case of an infection
To rid off the consequences of the cell injury after it has occurred
Summarily inflammation occurs in 5 steps which are
●Recognition of noxious stimuli by tissue- resident sentinel cells
● Recruitment of leukocytes and plasma proteins to the site of tissue injury or microbial invasion
●Removal of stimulus majorly by Phagocytosis cell
●Termination of reaction achieved by regulation
● Repair ( regeneration or scarring)
Inflammation as a double -edged sword
- It’s protective mechanism is associated by local tissue Dagenham and its associated signs and symptoms
- Misdirection of inflammatory signals
Direct toward a healthy tissue e.g autoimmune
Direct toward a normally harmless environmental substance e.g allergies - It is inadequately controlled
What are inflammatory mediators
Soluble factors that are produced in cells of the body or as plasma proteins
Triggered by inflammatory stimulus ( microbes, hypoxia and necrotic cells)
Their two major role is
Initiation
Amplification
What are inflammatory mediators
Soluble factors that are produced in cells of the body or as plasma proteins
Triggered by inflammatory stimulus ( microbes, hypoxia and necrotic cells)
Their two major role is
Initiation
Amplification
Distinguish between local and systemic circulation
Distinguish between local and systemic circulation
List the causes of inflammation
Necrotic cells
Infections
Foreign bodies
Hypersensitivity rxn( double edged sword)
Distinction between a transudate and exudate
The attachment of leukocytes to endothelial wall involves three processes :
Margination
Rolling ( loose adhesion)
Adhesion ( firm attachment)
What is the weibel - palade body
Stores of P-selectin
Other mediators such as ……………..
……………. redistribute p selectins from their intracellular store ( weibel - palade)
Histamine
Thrombin
The cytokines that induce the expression of selectins include
TNF
IL-1
The ligand for selectin Is ………
Sialylated oligosaccharide
What is the major opsonin
Ig G
Product of C3b breakdown
Tissue resident macrophage in the skin and intestinal tract originate from ……..
Hematopoietic stem cell.
Tissue resident cells in the liver, lungs and brain originate from ………….
Yolk sac
What kind of cells are present during chronic inflammation
Mononuclear cells
