Inflammation Flashcards
(23 cards)
Arachidonic acid metabolites
cell wall mediators- second messengers
Leukotrienes
Cause vascular permeability and chemotaxis- LOX system
Prostaglandins
Pain and vasodilatation- COX pathway
Vasoactive amines
performed, quickly released, Basophils and Mast Cells (Histamine) Platlets (serotonin)- increase vasodilation and permeability
Complement system
20 proteins- innate and adaptive immunity. Increase vasc. permeability, vasodilation, leukocyte adhesion, chemotaxis, phagocytosis
Cytokines
produced by 1 cell type to mediate fxn of different cell type- systemic acute phase reactions
Kinin system
increase vasc. perm, sm music contractions, vasodilation, pain
Interleukin 1
chemotaxis, fever, histamine, WBC release from bone marrow
Tumor necrosis factor
fever, WBC release from bone marrow
Nitric Oxide
macrophages- tissue distraction and vasodilation
exudate
inflammatory extravascular fluid, SG > 1.020
Exudation
escape of fluid- increase vasc perm., protein cells into interstitial tissue- acute inflammatory response
Transudate
Ultrafiltrate- low protein content out of vasc., SG 1.010- 1.015
pus
purulent (WBCs and bacteria) with parenchymal cell debris and leukocytes
Effusion
escape of fluid from anatomical vessels by exudation and rupture
abrasion
removal of first layer of dermis- regeneration with out scarring
laceration
accidental incision (stab wound)
incision
intentional- scalpal
crush
destruction of components of inner tissue- destroy vasc. and nerves
degloving
removal of skin and underlying structures from circular area
puncture
bacteria deep into skin with little opening
avulsion
chunk of skin and support structures removed- can’t bring back together
bite
large defects due to strength of jaw, underlying CT.
