Inflammatory Bowel disease Flashcards
(30 cards)
describe feautures concerning Chron’s disease
- Location
- Gross
- microscopic
- diharrea classification
- wall appearence
- malabsorbtion Yes or no?
Chrons=CROWN KING
- its the boss>> skips lesions, rectal sparing, TRANSMURAL inflamamtion, anywhere in GI (mostly terminal ileum and colon)
- 9j king 7aywan ;)*
- Cobblestone, creeping fat, perianal fistula and strictures, Anal lesions
- Granny> noncaseating granuloma
- THICK wall
YES
DEfine IBD inflammatory bowel disease
possible causes? (3)
chronic inflammatory condition resulting from inappropriate mucosal immune activation!
Causes
- genetics – could be heriditary
- disruption to the immune system – inflammation may be caused by the immune system attacking healthy tissue inside the digestive system while fighting off a virus or bacteria
- Gut organisms
name the 2 conditions
symtoms of chrons
which disease has a ‘cobble stone’ appearence? why?
Chrons disease
bc it skips lesions> scattered lesions> giving it a cobble stone appearence.
what is the main location of chrons disease?
all over GI from mouth to anus
but…
mostly ILEUM and COLON
Treatments in chron’s
Ulcerative colititis causes ULCCCERS
- *U**lcers
- *L**arge intestine
- *C**rypt abssess
- *C**olorectal carcinoma
- *C**ontinous
- *E**xtends proxiamally
- *R**ed diharrea
- *S**celording cholangitis
which of the 2 has Significant increased risk of colon cancer
why
UC> bc it is mostly related to the bowel
which one is most often severe in distal colon
UC
what is colectomy? which of the 2 is mostly asspciated in it?
Colectomy is a surgical procedure to remove all or part of your colon
UC
Patients with UC may develop complications in organs or tissues other than the gastrointestinal system.
Which organs/tissues can be involved and what complications can occur in them?
Skin= rash on legs, erythema nodosum/ painful Pyoderma gangrenosus(ulceration on leg) lump + ulceration of skin
- *Liver**= Primary sclerosoing cholangitis
- *Eye**= iris uveitis
- *Joints**= Ankylosing spondylitis
which of the 2 is most likley to be autoimmune disease?
UC
what is sclerosing cholangitis?
A breach in the lining of the bowel to the level of the submucosa or deeper (accept through the muscularis mucosa)
ulcer
2 classicial histological frautures of Chrons
Granulomas
trasmural (full thickness)
Difference in thichkness of lesion in chrONS and UC
Chrons >> transmural full thickness!
difference in Stools btw the 2?
chrons: nonbloody diharrea (but could be)
UC: BLOODYY
what is the typical presentation of Crohn’s disease?
multiple non-bloody loose stools/day
weight loss
right lower quadrant pain
in a 15-30 year old.
(some joint pains also)
smoker
why do u get thickening of the bowel wall in chrons?
cuz theres inflammation, so it heals then gets worse, heals then get worse>> making bowel thicker!
what is this called? why has it formed? what is it a9lan?
cobble stone appearence in chrons
the blobs r regenerating mucosa or edematous mucosae
and the redness in btw r deep ulceration!
how can u get a fistula in chrons?
They can occur if the abscess doesn’t heal properly after the pus has drained away.
investigations in chrons?
why cant we only rely on colonoscopy?
CT/MRI
barium enima>> reveals bowel obstruction, strictures and fistulae. (A barium enema is a test that helps to highlight the large bowel, so it can be clearly seen on an X-ray.)
Colonoscopy >> shows a cobblestone appearance and skip lesions.
we cant only do a colonoscopy bc remember chrons can effect anywhere in th GI!
which one most commonly effects YOUNG ADULTS?
Ulcerative colitis
