Inflammatory Disease

Question 1

Identify common causes of irritant and allergic contact dermatitis.

Answer 1

Irritant

• NON-immunologically mediated rxn from a direct cytotoxic effect
• Either from a single or repeated exposure to the irritant
• Ex. soap, skin products, perfume, wool, friction

Allergic

• NOT IMMEDIATE
• Requires contact exposure of an allergen, immune response and development of MEMORY T cells
• Type IV Delayed HSR
• Nickel, fragrances, poison ivy

Question 2

List common clinical associations and clinical presentation of atopic dermatitis.

Answer 2

FLEXOR SURFACES!!!!
Appearance: erythematous papules, redness, scaling and areas of lichenification

MUST HAVE ITCHY SKIN PLUS 3:

- Hx of involvement in skin creases (or face if pt < 10 yrs)
- Hx of asthma / hay fever (or FH of atopic disease if pt < 4 yrs)
- Hx of dry skin within the last year
- Visible flexural eczema (or face if pt < 4 yrs)
- Onset under 2 years of age

Question 3

Compare and contrast the clinical presentations of acne and rosacea

Answer 3

Acne
• impacts greasy areas

Rosacea
• Erythematous disorder of the central face (diffuse)
• No comedones and no involvement of the trunk
• Telangiectasias
• Flushing
• In 25% cases, eyelids and conjunctivae are involved