Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Block 11 module 5 > Inflammatroy Bowel Disease > Flashcards

Inflammatroy Bowel Disease Flashcards

(78 cards)

Start Studying
1
Q

idiopathic inflammatory intestinal disease resulting from an inappropriate immune activation to host intestinal micro flora

A

Inflammatory bowel disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

define IBD

A

it is an idiopathic inflammatory intestinal disease resulting from an inappropriate immune activation to host intestinal micro flora

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

types of IBD

A

Crohn’s Disease (CD)
Ulcerative Colitis (UC)
Others (Indeterminate colitis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

between UC and CD, which has a higher incidence?

A

incidence of UC is 3 times higher than that of CD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Autosomal recessive missense mutations of the interleukin (IL)-10 receptor gene cuses what?

A

cause severe disease through loss of function and, therefore, failure of IL-10 to down-regulate inflammation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Highest rates of IBD are seen among ____ population

A

Jewish

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

1st peak of IBD

A

15-40

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

2nd peak of IBD

A

55-65

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CD is associated with _____ gene polymorphisms and E. coli outer membrane and flagellin

A

NOD2/CARD15

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

interaction between ____ and ____ is critical to the pathogenesis of Crohn’s

A

T cells and APC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

genetic etiology of UC

A

IL-23R gene polymorphisms have been identified, most notably the Arg381Gln polymorphism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

pathogenesis of IBD

A

continuous antigenic stimulation by commensal enteric bacteria, fungi or viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

autoantibody that has received significant attention in UC patients

A

pANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Extends into the deeper layers of the intestinal wall and may affect the mouth, esophagus stomach and small intestines

A

CD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Transmural inflammation and skip lesions

A

CD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ulceration and inflammation of the inner lining of the colon and rectum

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

form of characteristic ulcers or open sores

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Symmetrical, continuous

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

DR2-related genes

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

DR5DQ1 alleles

A

CD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

pathologic hallmark of CD

A

Focal intestinal inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what is an aphthae

A

superficial ulcer in the mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Cobblestone appearance

A

CD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

35-50% CD is located in

A

both ileum and colon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
35% CD is located in
SI
26
late features of CD
Large ulcers, sinus tracts, and stricture, adhesion of bowel loops
27
macroscopic features of CD
``` skip lesions narrowing of lumen linear mucosal ulceration creeping fat fat wrapping ```
28
creeping of mesenteric fat onto the serosal surface of the bowel
fat wrapping
29
fat wrapping is seen in
CD
30
Granuloma
CD
31
CD compared to TB Ileitis
TB has no central and caseating necrosis
32
key cytokine in the formation of granulomas
TNF
33
if a granuloma is not seen what is a reliable sign of CD
presence of lymphoid aggregates in the submucosa and external to the muscularis propria
34
UC affects
only the colon
35
No skip pattern in
YC
36
total involvement of the colon
pancolitis
37
pancolitis is seen in
UC
38
involves only the rectum
proctitis
39
involves the rectum and sigmoid colon (the lower segment of the colon before the rectum)
Proctosigmoiditis
40
involves only the left side of the colon
Distal colitis
41
universal colitis; involves the entire colon
pancolitis
42
extension of UC into the terminal ileum
backwash ileus/ileitis
43
Inflammation in UC characteristically is confined to the
mucosa
44
pseudopolyps results from
coalescence of primary ulcerations in the area and later regeneration
45
epithelial regeneration intestinal mucosa with recurrent attacks results in the formation of
pseudopolyps
46
neutrophylic infiltration of colonic crypts leads to
cryptitis and crypt abscesses
47
Cryptitis – is associated with discharge of
mucus and goblet cells
48
Presence of plasma cells is another characteristic of
UC
49
major manifestatoin of IBD
recurrent ab pain and diarrhea
50
Grossly bloody stools, occasionally with tenesmus is typical in
UC
51
perianal lesions is a char of
CD
52
toxic megacolon is present in
UC
53
Fistulas are manifestations of the transmural nature of
CD
54
string sign is a feature of
CD
55
markedly narrowed bowel segment amid widely-spaced bowel loops
String sign
56
glucagon is used as an
antispasmodic
57
external manifestations of IBD
clubbing Arthritic manifestations Metabolic bone disease Granulomatous vasculaitis, periostitis and amyloidosis
58
gold standard for imaging studies in IBD
endoscopic evaluation
59
The presence of marked colonic dilatation suggests
fulminant colitis or toxic megacolon
60
string sign is due to
spasm
61
comb sign is pathognomonic of
CD
62
segmental dilatation of the vasa recta involving an intestinal loop
Comb sign
63
The earliest endoscopic sign of UC is
mucosal erythema and edema
64
what imaging modality would you do if you want to find obscure sources of GI blood loss
Tablet enteroscopy
65
complications of CD
``` Perforation • Abscess formation • Stricture and small bowel obstruction • Nutritional deficiency • Cancer: small bowel adenocarcinoma ```
66
complications of UC
toxic megacolon colon adenocarcinoma perforation massive hemorrhage
67
Mainstay of therapy for mild to moderate UC and CD
5 ASA agents
68
pro drug of 5 ASA
Balsalazine
69
the use of this demonstrated a prophylactic effect on endoscopic and clinical recurrence at one year
metronidazole
70
Utilized to initiate remissions particularly in persons who are not responding well to 5-ASA
glucocorticoids
71
Purine analogs that interfere with nucleic acid metabolism
Azathioprine and 6-Mercaptopurine
72
surgery is performed in UC or CD?
UC
73
idiopathic inflammation that may develop in patients who undergo IPAA
pouchitis
74
ASCA positive in
CD
75
Bleeding is more common in
UC
76
inflammation in mucosa and submucosa only
UC
77
Transmural inflammation
CD
78
factors affecting disease relapse and remission
``` Use of NSAIDS and antibiotics • Bacterial and viral infection • Smoking • Psychosocial stress • Both the severity and the extent of disease are important prognostic factors after the first attack of UC ```

Block 11 module 5 (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions