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Anesthesia Pharm 1-Josh > Inhaled anesthetics Josh > Flashcards

Inhaled anesthetics Josh Flashcards

I just made a few cards I personally wanted to concentrate on

1
Q

MAC values for Halothane Enflurane Isoflurane Desflurane Sevoflurane Nitrous oxide

A

Halothane-0.75 Enflurane-1.68 (1.7) Isoflurane-1.15 (1.2) Desflurane-6 Sevoflurane-2.1 Nitrous oxide-105

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2
Q

Blood/Gas of Halothane Enflurane Isoflurane Desflurane Sevoflurane Nitrous oxide

A

Halothane-2.4 Enflurane-1.9 Isoflurane-1.4 Desflurane-0.42 Sevoflurane-0.7 Nitrous oxide-0.46

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3
Q

Vapor pressure of Halothane Enflurane Isoflurane Desflurane Sevoflurane Nitrous oxide

A

Halothane-244 Enflurane-171 Isoflurane-239 Desflurane-669 Sevoflurane-170 Nitrous oxide-39,000

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4
Q

Metabolism of Halothane Enflurane Isoflurane Desflurane Sevoflurane Nitrous oxide

A

Halothane- 20% Enflurane-2% Isoflurane-0.2% Desflurane-0.02% Sevoflurane-2-5% Nitrous oxide-0.04%

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5
Q

what 2 VAA are not stabile in soda lime

A

halothane sevoflurane

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6
Q

Halothane MAC Blood/gas Vapor pressor metabolism Soda lime stabibility

A

MAC-0,75 Blood/gas-2.4 VP- 244 Met-20% Soda lime stabibility- no

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7
Q

what is halothane best used for

A

inhalation induction

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8
Q

what is the major SE of halothane

A

myocardial depression

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9
Q

what inhalation agent is an isomer of Isoflurane

A

enflurane

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10
Q

Enflurane is associaed with what SE

A

Seizures

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11
Q

Isoflurane MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC-1.15 (1.2) Blood/gas-1.4 Vapor pressure-239 Metabolism-0.2% Soda lime stabibility-yes * remember it wants to be one two (1.2) it’s an isomer. so: MAC 1.2 VP=2(39) Met= (0.)2

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12
Q

Desflurane MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC-6 Blood/gas- 0.42 Vapor pressure-669 Metabolism-0.02% Soda lime stabibility-yes * remember DES=6 so: MAC 6 VP=66(9) B/G=0.42 (4+2=6)

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13
Q

Sevoflurane MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC-2.1 Blood/gas-0.7 Vapor pressure-170 Metabolism-2-5% Soda lime stabibility-No *how to remember SEVO=7 so: B/G-(0.)7 VP (1)7(0) Met=2-5% (2+5=7)

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14
Q

N20 MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC- 105 Blood/gas- 0.46 Vapor pressure- 39,000 Metabolism-0.04% Soda lime stabibility- yes *how to remember N20>100 so: MAC=105 (>100) B/G= (0.)46 (4+6=10(0))

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15
Q

All inhalation agents are skeletal muscle relaxants EXCEPT for which one(s)

A

N20

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16
Q

What do all inhalation agents do to renal, with the exception of one, what doesthat one do, and which one is it?

A

all-decrease renal blood floe, GFR, and UOP -except for SEVO-it has high output renal failure

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17
Q

what is the only inorganic inhalation gas

A

N20

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18
Q

Which inhalation agent is a halonengated Alkane

A

Halothane

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19
Q

What can Halothane cause

A

Halothane Hepititis

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20
Q

Which inhalation agent is least expensive VAA, and is used all over the world

A

Halothane

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21
Q

Alkane substances such as soda lime can degrade what VAA?? and cause what toxicity?

A

-SEVO -Compound A

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22
Q

Prolonged exposure to N20 can cause what problem

A

Bone marrow depression -megoblastic anemia -pernicous anemia Neurological deficits -periphreal neuropathies

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23
Q

Which inhalation agent is halogenated with fluride, non pungent, and rapid increase in Alveolar concentration makes it a great choice for inhalation induction

A

SEVO

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24
Q

Which is the least potent Inhalation agent

25
Which inhalation agent is gas at room temp and ambiant pressure, and is able to be stored as a liquid under pressure?
N20
26
All inhalation agents decease B/P, what is the difference b/t halothane and the rest
Halothane decreases myocardial contractility and all others decrease SVR
27
What is the only inhalation agent the increases CMR02
N20
28
What do all inhalation agents do to CBF and ICP
increase it
29
What inhalation agent is tetatogenic
N20
30
Whats the FDA regulation for SEVO with flow rates
2 Lpm O2 flow if greater than 2 mac hours for ex: 1% X4 hrs 2% x 2 hours
31
Which inhalation agent is a potent bronchodilator and often reverses Asthma induced bronchospasms
Halothane
32
Any free fluride levels above what can cause problems
50
33
All inhalation agents decrease hepatic blood flow except which one? why?
SEVO b/c decrease portal vein blood flow is compensated by increased hepatic artery blood flow=maintained flow
34
Which inhalation agent undergoes spontaneous oxidative decomposition???what prevents this??
HAlothane thymal
35
What does halothane do to baroreceptors
inhibits bororeceptor reflexes
36
What does Isoflurane do to CV system that is unique to itself
Dilates coronary Arteries, can cause coronary steal syndrome
37
What special effects on the CV does Desflurane have
-rapid increases in consentrations can cause increased HR, B/P, and catecholamine levels -Most common agent to cause tachycardia -does not increase coronary blood flow
38
what unique thing does N20 do to the PULMONARY system
constriction of pulmonary vasculature, increases pulmonary vascular resistance
39
Which inhalation agent can cause carbon monoxide poisoning
Des
40
Enflurane MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility
MAC- 1.7 (1.68) Blood/gas- 1.9 Vapor pressure- 171 Metabolism. 2% Soda lime stabibilit-yes
41
The Pa mirrors what
Pbr (brain partial pressure)
42
what does increasing age do to MAC
decrease mac (abour 6% per decade)
43
MAC values for anesthetics are additive what does taht mean
0.5 MAC N20 + 0.5 MAC sevo =1 MAC
44
N=N \ / 0
Nitrous Oxide
45
HALOTHANE
46
CL F F | | | H-C-C-O-C-H | | | F F F
ENFLURANE
47
ISOFLURANE
48
DESFLURANE
49
SEVOFLURANE
50
what effects do temp have on MAC
Hypo-decrease Hyper-decrease
51
Age effects on MAC young old
Young-increase old-decrease
52
ETOH effects of MAC
Acute-decrease Chronic-increae
53
Anemias effect on MAC
decrease (HCT\<10%)
54
Pa02 effect on MAC
\<40mmhg decrease MAC
55
PaC02 effect on MAC
\>95 mmhg decrease MAC
56
B/P effect on MAC
MAP\<40 decrease MAC
57
Electrolyte effect on MAC Hyper Ca++ Hyper Na+ Hypo Na+
Hyper Ca++--decrease Hyper Na+--increase Hypo Na+--decrease
58
Pregnancy effect on MAC
decrease MAC
59
All drugs decrease MAC except for which one(s)
Cocaine ephedrine Acute amphetamine

Anesthesia Pharm 1-Josh (10 decks)

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