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Anesthesia Pharm I > Inhaled anesthetics Josh > Flashcards

Inhaled anesthetics Josh Flashcards

I just made a few cards I personally wanted to concentrate on

1
Q

MAC values for Halothane Enflurane Isoflurane Desflurane Sevoflurane Nitrous oxide

A

Halothane-0.75 Enflurane-1.68 (1.7) Isoflurane-1.15 (1.2) Desflurane-6 Sevoflurane-2.1 Nitrous oxide-105

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2
Q

Blood/Gas of Halothane Enflurane Isoflurane Desflurane Sevoflurane Nitrous oxide

A

Halothane-2.4 Enflurane-1.9 Isoflurane-1.4 Desflurane-0.42 Sevoflurane-0.7 Nitrous oxide-0.46

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3
Q

Vapor pressure of Halothane Enflurane Isoflurane Desflurane Sevoflurane Nitrous oxide

A

Halothane-244 Enflurane-171 Isoflurane-239 Desflurane-669 Sevoflurane-170 Nitrous oxide-39,000

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4
Q

Metabolism of Halothane Enflurane Isoflurane Desflurane Sevoflurane Nitrous oxide

A

Halothane- 20% Enflurane-2% Isoflurane-0.2% Desflurane-0.02% Sevoflurane-2-5% Nitrous oxide-0.04%

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5
Q

what 2 VAA are not stabile in soda lime

A

halothane sevoflurane

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6
Q

Halothane MAC Blood/gas Vapor pressor metabolism Soda lime stabibility

A

MAC-0,75 Blood/gas-2.4 VP- 244 Met-20% Soda lime stabibility- no

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7
Q

what is halothane best used for

A

inhalation induction

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8
Q

what is the major SE of halothane

A

myocardial depression

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9
Q

what inhalation agent is an isomer of Isoflurane

A

enflurane

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10
Q

Enflurane is associaed with what SE

A

Seizures

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11
Q

Isoflurane MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC-1.15 (1.2) Blood/gas-1.4 Vapor pressure-239 Metabolism-0.2% Soda lime stabibility-yes * remember it wants to be one two (1.2) it’s an isomer. so: MAC 1.2 VP=2(39) Met= (0.)2

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12
Q

Desflurane MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC-6 Blood/gas- 0.42 Vapor pressure-669 Metabolism-0.02% Soda lime stabibility-yes * remember DES=6 so: MAC 6 VP=66(9) B/G=0.42 (4+2=6)

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13
Q

Sevoflurane MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC-2.1 Blood/gas-0.7 Vapor pressure-170 Metabolism-2-5% Soda lime stabibility-No *how to remember SEVO=7 so: B/G-(0.)7 VP (1)7(0) Met=2-5% (2+5=7)

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14
Q

N20 MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC- 105 Blood/gas- 0.46 Vapor pressure- 39,000 Metabolism-0.04% Soda lime stabibility- yes *how to remember N20>100 so: MAC=105 (>100) B/G= (0.)46 (4+6=10(0))

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15
Q

All inhalation agents are skeletal muscle relaxants EXCEPT for which one(s)

A

N20

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16
Q

What do all inhalation agents do to renal, with the exception of one, what doesthat one do, and which one is it?

A

all-decrease renal blood floe, GFR, and UOP -except for SEVO-it has high output renal failure

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17
Q

what is the only inorganic inhalation gas

A

N20

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18
Q

Which inhalation agent is a halonengated Alkane

A

Halothane

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19
Q

What can Halothane cause

A

Halothane Hepititis

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20
Q

Which inhalation agent is least expensive VAA, and is used all over the world

A

Halothane

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21
Q

Alkane substances such as soda lime can degrade what VAA?? and cause what toxicity?

A

-SEVO -Compound A

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22
Q

Prolonged exposure to N20 can cause what problem

A

Bone marrow depression -megoblastic anemia -pernicous anemia Neurological deficits -periphreal neuropathies

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23
Q

Which inhalation agent is halogenated with fluride, non pungent, and rapid increase in Alveolar concentration makes it a great choice for inhalation induction

A

SEVO

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24
Q

Which is the least potent Inhalation agent

A

N20

25
Q

Which inhalation agent is gas at room temp and ambiant pressure, and is able to be stored as a liquid under pressure?

A

N20

26
Q

All inhalation agents decease B/P, what is the difference b/t halothane and the rest

A

Halothane decreases myocardial contractility and all others decrease SVR

27
Q

What is the only inhalation agent the increases CMR02

A

N20

28
Q

What do all inhalation agents do to CBF and ICP

A

increase it

29
Q

What inhalation agent is tetatogenic

A

N20

30
Q

Whats the FDA regulation for SEVO with flow rates

A

2 Lpm O2 flow if greater than 2 mac hours for ex: 1% X4 hrs 2% x 2 hours

31
Q

Which inhalation agent is a potent bronchodilator and often reverses Asthma induced bronchospasms

A

Halothane

32
Q

Any free fluride levels above what can cause problems

A

50

33
Q

All inhalation agents decrease hepatic blood flow except which one? why?

A

SEVO b/c decrease portal vein blood flow is compensated by increased hepatic artery blood flow=maintained flow

34
Q

Which inhalation agent undergoes spontaneous oxidative decomposition???what prevents this??

A

HAlothane thymal

35
Q

What does halothane do to baroreceptors

A

inhibits bororeceptor reflexes

36
Q

What does Isoflurane do to CV system that is unique to itself

A

Dilates coronary Arteries, can cause coronary steal syndrome

37
Q

What special effects on the CV does Desflurane have

A

-rapid increases in consentrations can cause increased HR, B/P, and catecholamine levels -Most common agent to cause tachycardia -does not increase coronary blood flow

38
Q

what unique thing does N20 do to the PULMONARY system

A

constriction of pulmonary vasculature, increases pulmonary vascular resistance

39
Q

Which inhalation agent can cause carbon monoxide poisoning

A

Des

40
Q

Enflurane MAC Blood/gas Vapor pressure Metabolism Soda lime stabibility

A

MAC- 1.7 (1.68) Blood/gas- 1.9 Vapor pressure- 171 Metabolism. 2% Soda lime stabibilit-yes

41
Q

The Pa mirrors what

A

Pbr (brain partial pressure)

42
Q

what does increasing age do to MAC

A

decrease mac (abour 6% per decade)

43
Q

MAC values for anesthetics are additive what does taht mean

A

0.5 MAC N20 + 0.5 MAC sevo =1 MAC

44
Q

N=N \ / 0

A

Nitrous Oxide

45
Q
A

HALOTHANE

46
Q

CL F F | | | H-C-C-O-C-H | | | F F F

A

ENFLURANE

47
Q
A

ISOFLURANE

48
Q
A

DESFLURANE

49
Q
A

SEVOFLURANE

50
Q

what effects do temp have on MAC

A

Hypo-decrease Hyper-decrease

51
Q

Age effects on MAC young old

A

Young-increase old-decrease

52
Q

ETOH effects of MAC

A

Acute-decrease Chronic-increae

53
Q

Anemias effect on MAC

A

decrease (HCT<10%)

54
Q

Pa02 effect on MAC

A

<40mmhg decrease MAC

55
Q

PaC02 effect on MAC

A

>95 mmhg decrease MAC

56
Q

B/P effect on MAC

A

MAP<40 decrease MAC

57
Q

Electrolyte effect on MAC Hyper Ca++ Hyper Na+ Hypo Na+

A

Hyper Ca++–decrease Hyper Na+–increase Hypo Na+–decrease

58
Q

Pregnancy effect on MAC

A

decrease MAC

59
Q

All drugs decrease MAC except for which one(s)

A

Cocaine ephedrine Acute amphetamine

Anesthesia Pharm I (9 decks)

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