Inhibitors

Question 1

Drugs that are competetive inhibitors

Answer 1

Methotrexate
Allopurinol
Satins
Imatibin

Question 2

Methotrexate

Answer 2

(competetive)
cancer therapy

inhibitor of dihydrofolate reductase

Question 3

Allopurinol

Answer 3

(competetive)
treatment of gout

inhibits xanthine oxidase (produces uric acid by breakdown)

Question 4

Satins

Answer 4

(competetive)
treats hypercholesterolaemia

inhibits 3-hydroxy-3-methylglutanyl coenzyme A reductase (catalises conversion of HMG-coA to melalonate in cholesterol synthesis)

Question 5

Imatibin

Answer 5

(competetive)
Cancer therapy

inhibits Bcr-Abl tyrosine kinase (drivesz cell divison)

Question 6

Drugs that are uncompetetive inhibitors

Answer 6

RARE

lithium

Question 7

Lithium

Answer 7

(uncompetetive)
Manic depressive episodes

inhibitor of myo-inositol monophosphate

Question 8

Drugs that are non-competetive inhibitors

Answer 8

nevirapine
evirapine

Question 9

nevirapine + evirapine

Answer 9

(non-competetive)
HIV

non-nucleoside RT inhibitors

Question 10

Drugs that are suicide inhibitors

Answer 10

Aspirin
Penicillin
Eflornithine

Question 11

Aspirin

Answer 11

(suicide)
Blood thinner + painkiller

inhibits cyclooxygenase (basic houskeeping)

Question 12

penicillin

Answer 12

(suicide)
antibiotic

inhibits D-analyl-D-Alanine transpeptidase (cell wall synthesis)

Question 13

Eflornithine

Answer 13

(suicide)
African sleeping sickness

inhibits orthinine decarboxylase (precursor for rapid cell division)