Inhibitors of Nucleic Acid Synthesis (abtcs)

Question 1

Name the drugs (3)

Answer 1

sulfonamides
trimethoprim
rifampin

Question 2

Are these drugs good for G+, G- or both?

Answer 2

all are good for both

Question 3

inhibitors of nucleic acid synth: cidal?

Answer 3

sulfonamids/trimethoprim at high doses

rifampin always cidal

Question 4

inhibitors of nucleic acid synth: static?

Answer 4

sulfonamides/trimethprim at low doses

Question 5

inhibitors of nucleic acid synth: metabolized in liver?

Answer 5

rifampin only

Question 6

inhibitors of nucleic acid synth: used for TB?

Answer 6

rifampin

Question 7

inhibitors of nucleic acid synth: serious side effects?

Answer 7

sulfonamides: cystalluria (drink lots of water), do not give to newborns (kernicterus), steven-johnson hypersensitivity reaction

Question 8

inhibitors of nucleic acid synth: good for pseudomonas?

Answer 8

none

Question 9

inhibitors of nucleic acid synth: which should you not use in mono therapy?

Answer 9

rifampin