Inmunologia Flashcards
(25 cards)
TLR4
PRR bacteria
TLR3,8,9
PRR in virus
Epitope
Part of the antigen recognized
Paratope
Part of the receptor/Ig that binds the epitope
Inmunogen
Antigeno que inicia respuesta adaptativa
adjuvants
molecules activating innate inmunity
CDR
Complementarity determining regions. Place of the antibody where the antigen binds
Antibody functions
B cell receptor(hidrophobic tail) and soluble molecule (lack hidrophobic tail)
how many constant domains in Ig
3
how many constant domains in IgE or IgM
4
Que celulas se unen al Fc en opsonizacion
Macrofagos y neutrofilos
Which Ig promotes complement activation
IgM and IgG
Which cells carry out ADCC
Eosinophils and NK that bind Fc of Ig
Which cells are activated by IgE
Granulocytes
IgM binding sites and function
Neutralization, 10
IgG1 and IgG3 function
Opsonization, ADCC (complement activation in IgG3)
Which can cross the placenta and which can activate complement
IgG1,2,4. IgG3
IgA binding sites and function
4 sites. Transcytosis (external secretions)
Most present in serum (IG)
IgG
Idiotype
Sum of CDR that makes the variable region. Provides specificity. Same in all of the same Bcell.
In which chain J is asociated with C
lamda light chain
Que es RAG1-RaG2
recombinase complex, cleaves genes
diversity in mature Bcells is given by
somatic hypermutation and isotope swiching
Allelic exclusion explain
Heavy chain check one then the other. Light start with KAPPA. If neither allele works, go for lambda.
