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Flashcards in Innate Cells Deck (12):
1

What do leucocytes release when they perceive a threat?

cytoplasm contains granules that are loaded with killer/hydrolytic/oxidizing
-can't discriminate between pathogen and underlying tissue

2

What are the two groups of leucocytes?

neutrophils and macrophages

3

cytokines

communicators of the immune system
-lymphocytes and macrophages use cytokines to regulate the intensity of an immune response

4

neutrophils

-multi-lobed nucleus (PMNs)
-granulocytic myloid cells
-most abundant WBC
-most important in innate immune system
-most numerous
-usually circulate
-rarely found in normal tissues
-die after 1 round of phagocytosis
-for large pathogens they use extracellular killing
-can spill guts (antimicrobial but also can cause local tissue damage)
-NETs
-PUS!!!!

-ultimate phagocytic, rapid response pathogen destroyer

5

macrophage

-in tissues
-do not have prominent granules but are filled with lysosomes for phagocytosis and intracellular killing
-antigen presentation
-call neutriphils and adaptive cells
-produce inflammatory mediators such as swelling redness warmth and pain at the sight of infection
-PAMPs highly expressed

-effective killer both phagocytic and non pahgocytic mechanism

6

dendritic cells

-phagocytosis-antigen presenting cell
-found in most tissues similar to macrophages
-phagocytosis and macropinocytosis
-crucial link between innate and adaptive immunity
-PAMPs highly expressed
-direct the type of adaptive response based on TLR activtion and or interaction with other innate cells, especially NK and gamma delta lymphocytes
-can secrete different cytokines that also shape character of adaptive response

-the best professional APC

7

eosinophils

granulocytes
-neutralizing and destroying large parasitic invaders
-help sustain allergic responses causing them to be chronic-->can do damage to surround tissue that can be permanent and significant

8

mast cells

-contain acidic hitamine
-allergies
-open vascular doors to allow recruited WBC to enter infection
-non pathogenic allergen-->systemic vasodilation and vascular permability with loss of blood pressure, airway constriction, swelling of hte epiglottis

9

Basophils

accomplice to mast cells and eosinophils
-antiparasitic and allergic reactions

10

NK cells

primarily attack virus infected cells or tumor cells and release their granules that cause lysis of their target
-similar receptors to that on adaptive immune cells but do not become specific to one type of anitgen
-notice something fishy about infected or altered (tumorous)

-non-antigen specific killer

11

NKT cells

subset of Tcells
-TLR that is restricted to glycolipid antigens

12

gamma delta lymphocytes

-recognize lipid biosynthesis in bacteria
-large amount in respiratory and gastrointestinal submucosa
-environmental interfaces