Flashcards in Innate immunity Deck (10):
What are Fc receptors?
- Present on phagocytes
- Bind to the constant region of antibodies
What are interferons?
- Inhibit viral replication
- Secreted by: lympocytes, macrophages, virally infected cells
What do interferons do?
1) Signals neighboring UNINFECTED cells to destroy RNA and reduce protein synthesis
2) Signals neighbouring INFECETED cells to undergo apoptosis
3) Activates immune cells
What are PRRs?
- RLR (in cytosol)
How are natural killer cells activated?
How do natural killer cells kill cells?
- Release granules containing
- Perforin which punctures holes in the cell
- AND granzyme which activate caspase (a protease)
What cells contribute to immunological suvaillance?
Natural killer cells
What do dendritic cells do?
- Activated by PRRs
- Cleave proteins into peptdie fragments
- Migrate to lymph node and activated T cells
What do defensins do?
- Bind to pathogen bilayer and form pores