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Pathobiology > Innate immunity > Flashcards

Flashcards in Innate immunity Deck (10):
1

What are Fc receptors?

- Present on phagocytes
- Bind to the constant region of antibodies

2

What are interferons?

- Inhibit viral replication
- Secreted by: lympocytes, macrophages, virally infected cells

3

What do interferons do?

1) Signals neighboring UNINFECTED cells to destroy RNA and reduce protein synthesis

2) Signals neighbouring INFECETED cells to undergo apoptosis

3) Activates immune cells

4

What are PRRs?

- TLR
- NLR
- CLR
- RLR (in cytosol)

5

How are natural killer cells activated?

By interferons

6

How do natural killer cells kill cells?

- Release granules containing
- Perforin which punctures holes in the cell
- AND granzyme which activate caspase (a protease)

7

What cells contribute to immunological suvaillance?

Natural killer cells
Dendritic cells

8

What do dendritic cells do?

- Activated by PRRs
- Cleave proteins into peptdie fragments
- Migrate to lymph node and activated T cells

9

What do defensins do?

- Ampipathic
- Bind to pathogen bilayer and form pores

10

What forms the MAC?

C3b from C3 in the compliment system