Insomnia Flashcards

1
Q

Facts about sleep

A

Sleep is vital

Part of circadian rhythm – many functions including growth, rest & recovery.

Pattern varies throughout life

Adults need 4 to 9 hours sleep

Deprivation leads to –ve effect on mood, motivation, alertness, memory & physical function.

Lab rats die after 14 days of no sleep!!

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2
Q

Normal adult sleep pattern in one night

A
Level of sleep is not the same
Goes via several stages of sleep 
REM- Shallowest stage of sleep, they are most aware and the brain is functional 
 waking in between cycle
They do not spend more time at REM sleep
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3
Q

Define Insomnia

A

A condition of unsatisfactory quantity and/or quality of
sleep which persists for a considerable period of time,
including difficulty falling asleep, difficulty in staying
asleep, or early final wakening.

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4
Q

Insomnia is a common

symptom of many mental and physical conditions. True or false?

A

True

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5
Q

How Insomnia is described

A
Can be indicated if an individual reports two or more of the following:
Take more than 30 mins to go to sleep
Difficulty maintaining sleep
Disturbed sleep  - >3 x per week
Daytime functioning impaired
Short but healthy sleep vs. insomnia
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6
Q

State the two types of Insomnia

A
  1. Primary Insomnia

2. Secondary Insomnia

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7
Q

What type of insomnia comes from an unknown origin or arises from sleep environment?

A

Primary Insomnia

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8
Q

Define secondary Insomnia

A

Insomnia that arises due to an underlying psychological or physical condition

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9
Q

List and briefly explain the classification of insomnia due to duration of symptoms

A
  1. Transient Insomnia- Lasts 2-3 days
  2. Short-term- Lasts longer than three days, but
    <3 weeks
  3. Long-term (chronic) -Lasts longer than three
    weeks
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10
Q

A high level of cortisol production during the day and at night time could result in lack of sleep. True/false.

A

True

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11
Q

What is the common reason for the excessive production of cortisol

A

One common reason for the excessive production of cortisol is tumor in the pituitary gland

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12
Q

Production of high levels of steroids hormones leads to what type of insomnia?

A

Secondary Insomnia

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13
Q

Most of the P medicines are licensed for short term and transient insomnia. True/false

A

True

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14
Q

Epidemiology of Insomnia

A

About 10-38% of all people have sleep problems in any given year
In a UK study, 30-48% of people reported insomnia symptoms and 8-18% sleep dissatisfaction, only 6% met the criteria for a diagnosis of insomnia
Prevalence seems to be greater in women, older people, and those who are socioeconomically disadvantaged
Insomnia typically develops at times of increased life stress

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15
Q

Primary Insomnia mainly caused by;

A
  1. A poor sleep environment e.g. light, noise, heat
  2. Behaviour that makes sleep difficult e.g.
    Physical / intellectual arousal
  3. Varying sleep routine – mismatch between
    attempts to sleep and circadian rhythm e.g. Jet-
    lag and shift
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16
Q

State the ‘5 P’s’ approach to causes of secondary Insomnia

A

1.Physical- CV disease; COPD/asthma; pain
2.Physiological- Late heavy meals, high in fat or
protein or both
3.Psychological- Stress; tension; grief;
ASPS/DSPS
4. Psychiatric- Mood and/or anxiety disorders
5. Pharmacological- Alcohol; medicines; illicit
recreational drugs

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17
Q

What is ASPS?

A

Advanced Sleep Phase Syndrome- The patient becomes really tired much earlier in the day than you would expect, they feel like its late at sort of tea time. Their 24 hour is shorter in ASPS

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18
Q

Whats DSPS?

A

Delayed Sleep Phase Syndrome- 24hour longer in
DSPS
This is where the patient does not keep to 24-hour pace circadian rhythm

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19
Q

Effect of Alcohol on the sleep cycle

A

Alcohol prevents deep sleep (REM) REM cycle from happening, it does not provide a refreshing sleep although it helps people to sleepalcohol-fuelled sleep is marked less refreshing than the non-alcohol fuelled sleep

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20
Q

List POMs which can cause insomnia

A
Anticonvulsants (Phenytoin, Lamotrigine)
Beta-blockers (Atenolol, Propranolol)
SSRIs (Fluoxetine, Sertraline)
Antiparkinson drugs (Levodopa)
Decongestants (Pseudoephedrine)
Corticosteroids (Prednisolone, Dexamethasone)
Levothyroxine
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21
Q

List Information needed for diagnosis of Insomnia

A

Detailed questioning required
Sleep diary
Patient records sleep diary over 2 weeks
Includes:
quantity of sleep, awakenings during night,
quality of sleep,
activity during the day, caffeine, nicotine

this helps to establish a pattern

22
Q

List the relevant information needed for the diagnosis of Insomnia

A

pattern of sleep
daily routine
underlying medical condition
Recent travel

23
Q

When to refer a patient suffering from Insomnia

A
Children under 12
Longer than 3 weeks
No known cause
Previous undiagnosed medical conditions
Symptoms of anxiety/depression
Other sleep disorders
Sleep apnoea
Narcolepsy
Hypersomnia
24
Q

List the available treatment options for Insomnia

A
Sleep hygiene
OTC Medication:
Diphenhydramine
Promethazine
Herbal products
POM Medication
25
Sleep hygiene measures includes;
Sleep hygiene – developing a routine Reducing caffeine, nicotine; address alcohol intake Increasing exercise Bathing before bedtime Avoiding Carbohydrate intake before bed
26
Facts about Diphenhydramine as a treatment option for Insomnia
A large body of evidence Consistently superior to placebo in terms of induction of sleep, using 50mg ON 50mg is as effective as 60mg sodium pentobarbital. No increase in effectiveness over 50mg ADRs – antimuscarinic, additive sedation Do not use in: glaucoma, prostatic enlargement TREATMENT OF CHOICE
27
Diphenhydramine is contraindicated in what kind of condition?
Do not use in glaucoma, prostatic enlargement
28
What is the brand name of Diphenhydramine?
Nytol
29
State the dosage of Diphenhydramine 50mg tablets
Adult dose - Over 16; 1 tablet taken 20 mins before bed
30
Is Diphenhydramine recommended for under 16years old?
Children (under 16) not recommended
31
State the dosage of 25mg Diphenhydramine tablet.
Diphenhydramine 25mg tablets (Adult dose - Over 16) - 2 tablets taken 20 mins before bed Children (under 16) - not recommended
32
Facts about Promethazine
Widely accepted but only 1 trial found Adam and Oswald (1986) – 12 healthy volunteers, placebo or 20 or 40mg Promethazine Both doses increased length of sleep and reduced sleep disturbances cf placebo Not clear if statistically significant. Same ADRs / CI as Diphenhydramine
33
What is the brand name of Promethazine?
Sominex
34
What is dosage for 20mg Promethazine tablet?
``` Promethazine 20mg tablets Adult dose (over 16) – One tablet at bedtime Child dose (under 16) – not recommended ```
35
List the herbal products available for the treatment of insomnia
``` Valeriana officinalis Hops (NOT beer though!!!) Wild lettuce – powdered extract Passionflower –leaves, flowers & fruit Lemon balm - leaves Lavender - flowers Jamaica dogwood – root bark ```
36
Facts about Valerian
Many trials, not all easy to compare so meta-analysis is difficult Most show subjective improvement in patients perception of insomnia Often patients state that their insomnia is ‘much improved’ Not much hard evidence One trial shows similar effects to low-dose Oxazepam. .
37
List the ADRs of Valerian
Hepatotoxicity and impairment
38
State the dosage of Valerian used for the treatment of Insomnia
Blend of Valerian, Hops, and Passionflower | 2 tablets one hour before bedtime
39
Facts about Hypnotics
``` Prescribers must weigh up risk vs. benefit Rx only in short-term cases 1 or 2 doses may suffice in these cases BNF – Limit course to 2-4 weeks max Intermittent ( every 3 nights) dosing Tolerance develops within 14 days!! ```
40
Facts about Benzodiazepines
Act on GABA by binding to benzodiazepine receptors, boosting inhibitory action of GABA. CSM warning to only use when insomnia is severe, disabling and causing stress Do change sleep ‘type’ reducing REM sleep – associated with dreaming. Seems to reduce quality
41
when should Benzodiazepines be used in the treatment of Insomnia according to CSM?
CSM warning to only use when insomnia is severe, disabling, and causing stress
42
List examples of short-acting benzodiazepines?
Temazepam, Lorazepam
43
List examples of Long-acting Benzodiazepines
Nitrazepam
44
State the dosage of Temazepam
Temazepam: 10-40 mg ON
45
What is the dose of Temazepam in elderly patients?
10mg for elderly (20mg exceptionally
46
Temazepam. is recommended in children. True/false?
True
47
What kind of effect is seen in patients on Short-acting Benzodiazepines?
little hangover effect
48
Benzodiazepine is a CD schedule .....
3
49
List the ADRs of Benzodiazepines
Drowsiness, light-headedness, Confusion, ataxia, amnesia, dependence
50
Facts about Z- drugs?
Zopiclone, Zolpidem, Zalepon Non-benzodiazepines, but act on GABA Short duration of action ADRS – Similar to Benzodiazepines PLUS tremors, libido changes Perceived by Psychiatrists to cause less dependence than Benzodiazepines (Pharm J 11/5/2002) More expensive than Benzodiazepines
51
Facts about Hypnotic withdrawal programme
Transfer to equivalent diazepam dose Reduce dose every 2/52, in 2-2.5 mg stages Stop for a while if symptoms start Reduce in smaller steps if needed near end of process Stop completely Timescale: 4 weeks to 1 year !