Insomnia Flashcards

(68 cards)

1
Q

What is sleep latency?

A

time to fall asleep following bedtime

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2
Q

what is WASO?

A

wake after sleep onset
sum of wake times from sleep onset to final awakening

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3
Q

What is TIB?

A

time in bed
time from bedtime to getting out of bed

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4
Q

What is TST?

A

total sleep time
TIB - SL - WASA

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5
Q

how is sleep efficacy calculated?

A

TST/TIB x 100

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6
Q

what are the 4 stages of sleep?

A
  1. the lightest sleep stage and easiest to be woken from
  2. a deeper sleep state and most of our sleep occurs in this phase
  3. the deepest stage of sleep and it is the hardest to wake from
  4. REM sleep stage: where dreaming occurs
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7
Q

what are the 2 basic types of sleep?

A

REM sleep and non REM sleep

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8
Q

What percent of sleep is REM sleep?

A

25%

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9
Q

What neurotransmitters are wake promoting?

A

glutamate
ACh
dopamine
NE
serotonin
histamine
orexin/hypocretin

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10
Q

what neurotransmitters promote non REM sleep?

A

GABA
galanin
adenosine
melatonin

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11
Q

what neurotransmitters promote REM sleep?

A

ACh
glutamate
GABA
glycine

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12
Q

What is required for an insomnia diagnosis (DSM-5)

A

A. predominant complaint of dissatisfaction with sleep quantity or quality made by patient

B. report one or more of the following sx:
- difficulty initiating sleep
- difficulty maintaining sleep
- early morning awakening with inability to return to sleep
- non restorative sleep
- persistent resistance to going to bed

C. the sleep complaint is accompanied by great distress or impairment in the daytime by report of one of the following:
- fatigue or low energy
- daytime sleepiness
- cognitive impairment
- mood distubrances
- behaviour difficulties
- impaired occupational/academic functioning
- impaired interpersonal/social function
- negative effect on caregiver or family functioning

D. the sleep difficulty occurs at least 3 nights a week

E. the sleep difficulty is present for at least 3 months

F. the sleep difficulty occurs despite adequate opportunity for sleep

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13
Q

What is the duration of acute, sub chronic and persistent insomnia?

A

acute insomnia = <1 month

sub-chronic insomnia = 1-3 months

persistent insomnia = >3 months

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14
Q

what is the clinical definition of insomnia?

A

SL >30 mins
WASO >30 mins
SE <80%
TST <6.5 hours
occurring at least 3 nights per week

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15
Q

what is primary insomnia vs secondary insomnia?

A

primary insomnia: insomnia in the absence of a cumulative factor

secondary insomnia: insomnia caused by an underlying medical condition or medication adverse effect

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16
Q

what question could you ask to rule out sleep apnea?

A

“are you a heavy snorer? does your partner say that you sometimes stop breathing at night”

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17
Q

what question could you ask to rule out restless leg syndrome?

A

“when you try to relax in the evening or sleep at night, do you ever have unpleasant restless feelings in your legs that can be relieved by walking or movement?”

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18
Q

what question can you ask to rule out narcolepsy?

A

“do you sometimes fall asleep in the daytime completely without warning? do you have collapses or extreme muscle weakness triggered by emotion, for instance when you are laughing?”

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19
Q

what question can you ask to rule out circadian rhythm sleep disorder?

A

“do you tend to sleep well but just at the ‘wrong times’ and are these sleeping and waking times regular?”

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20
Q

what question can you ask to rule out parasomnias?

A

“do you have unusual or unpleasant experiences or behaviours associated with your sleep that trouble you or are dangerous?”

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21
Q

Differential diagnosis of insomnia

A

obstructive sleep apnea syndrome (OSAS)
restless leg syndrome (RLS)
narcolepsy
circadian rhythm sleep disorder (CRSD)
parasomnias

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22
Q

what does your score on the Athens insomnia scale mean?

A

0-5 = absence of insomnia
6-9 = mild insomnia
10-15 = moderate insomnia
16-24 = severe insomnia

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23
Q

What kind of questions does the Epworth sleepiness scale ask?

A

“how likely are you to fall asleep in the following situations?”

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24
Q

What score on the Epworth sleepiness scale is of concern?

A

10 or greater

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25
T or F sleep complaints increase with age
true
26
T or F insomnia is more common in men than it is in women
false twice as prevalent in women
27
what are some risk factors for insomnia?
stress increased age female sex lower economic status medical comorbidities: nocturia, HF, COPD, depression/anxiety, dementia shift worker
28
Which drugs may cause insomnia?
antidepressants: bupropion, MAOIs, SNRIs, SSRIs CV: alpha blockers, beta blockers, diuretics, statins decongestants opioids respiratory: beta agonists, theophylline stimulants others: acetylcholinesterase inhibitors, alcohol, antineoplastics, CSs, dopamine receptor agonists, nicotine, medroxyprogesterone, phenytoin, thyroid supplements
29
what are the 5 most common medications that disturb sleep?
levodopa prednisone venlafaxine fluvoxamine rotigotine
30
what are the health outcomes associated with insomnia?
CV: stroke, CHD, inflammatory markers metabolic: obesity, T2D, impaired glucose tolerance cancer accidents
31
what are our primary goals of therapy for insomnia?
sleep quality and/or time insomnia related daytime impairments like energy, attention, or memory impairment
32
what are secondary goals of therapy for insomnia?
SL <30 mins WASA <30 mins decrease frequency of awakening TST >6 hours and/or SE >80-85% sleep related psychological distress formation of a positive and clear association between bed and sleeping
33
what are the actions to promote sleep in insomnia? (bottom of pyramid)
1. optimize management of comorbid medical and psychiatric conditions 2. initiate daytime behaviour modifications 3. adjust sleep environment 4. set specific sleep and wake times 5. decrease arousal/anxiety 6. initiate cognitive therapy
34
what are the components of CBT-i?
cognitive therapy stimulus control sleep restriction sleep hygiene relaxation
35
what is the cognitive therapy portion of CBT-i?
aims to identify, challenge, and replace dysfunctional beliefs and attitudes about sleep and insomnia
36
what is the stimulus control portion of CBT-i?
behavioural instructions aimed at strengthening the association between bed and sleep and preventing conditioning of the patient to associated bed with other stimulating activities
37
what is the sleep restriction portion of CBT-i?
behavioural instructions to limit time in bed to match perceived sleep duration in order to increase sleep drive and further decrease time awake in bed
38
what is the sleep hygiene portion of CBT-i?
general recommendations relating to environmental factors, physiologic factors, behaviour and habits that promote sound sleep
39
what is the relaxation portion of CBT-i?
any relaxation technique that the patient finds effective can be used to limit cognitive arousal and decrease muscular tension to facilitate sleep
40
what are some instructions for good sleep hygiene?
do not spend too much time in bed maintain a consistent sleep/wake time get out of bed if unable to fall asleep exercise regularly keep bedroom comfortable dont take problems to bed avoid caffeine, tobacco and alcohol after lunch limit liquids in the evening/dont go to bed hungry keep bedroom dark and quiet avoid late night screen time
41
what are some relaxation techniques for insomnia?
breathing exercises progressive muscle relaxation imagry medication
42
T or F pharmacotherapy should be considered only as an adjunct to CBT-i
true
43
How long should z-drugs and benzos be used for?
<4 weeks
44
what happens when drugs bind to GABA receptors?
GABA exerts a calming effect on the CNS increase the efficiency of GABA to decrease the excitability of neurons
45
what are the short acting benzos?
alprazolam midazolam triazolam
46
what are the characteristics of short acting benzos?
tend to cause more amnesia withdrawal sx and potential dependency
47
what are the medium acting benzos?
lorazepam oxazepam temazepam clonazepam
48
which benzos have no active metabolites?
LOT lorazepam oxazepam temazepam
49
what are the long acting benzos?
bromazepam diazepam chlordiazepoxide
50
which benzos have the highest risk of dependency?
short acting
51
T or F eszopiclone was shown to be superior to zopiclone
false
52
how long do benzos increase you sleep time by?
25 minutes and decrease 1 nighttime awakening
53
what are some side effects of benzos?
daytime drowsiness fatigue headache nightmares nausea upset stomach increased risk of falls
54
T or F increased risk for accidents associated with benzos increase with alcohol use
true
55
how to antihistamines work for sleep?
block H2 receptors which decreases wakefulness
56
what is the efficacy of antihistamines in insomnia?
minimal effect on SL and TST
57
how long does it take to build a tolerance to the sleeping effects of antihistamines?
3 to 4 days of continuous therapy
58
what are some adverse effects of antihistamines?
dry mouth constipation blurred vision orthostatic hypotension increased appetite
59
what antihistamines and doses are recommended for sleep?
diphenhydramine 50 mg HS hydroxyzine 25-100mg HS
60
T or F antihistamines are recommended for insomnia
false
61
what is the MOA of melatonin?
hormone produced by the pineal gland that helps regulate the sleep/wake cycle
62
what is the efficacy of exogenous melatonin?
decrease SL by 8 mins but no effect on SE
63
what are some AEs of melatonin?
nausea headache dizziness daytime drowsiness
64
which TCAs are used in insomnia?
amitriptyline and nortriptyline
65
what is the efficacy of TCAs in insomnia?
increased sleep length and efficacy, decreased nocturnal disturbances and increased TST fewer changes in REM parameters
66
what is the dosing of TCAs for insomnia patients without depression?
25-50 mg HS
67
what are some precautions with TCAs?
problematic in elderly (anticholinergic) BPH, HTN, arrhythmia, epilepsy
68