INTEGRASE INHIBITOR Flashcards
1
Q
A
RALTEGRAVIR
Key aa for Integrase catalytic site: Asp 64, Asp 116 and Glu 162 (highly negative charged, gets balanced with two divalent metal ions)
First Integrase Inhibitor
Forms Wan-der Waals intx with bases of DNA, preventing strand transfer (fluorinated phenol gets in the way)
Chelates two metal ions using cheto oxygens in the drug
