Interactions Flashcards by J H

Q

Sulfonylureas

A

CYP inhibitors

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Q

Carbamazepine

A

CYP inhibitor

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Q

Rifampicin

A

CYP inhibitor

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Q

Alcohol (chronic use)

A

CYP inhibitor

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Q

Phenytoin

A

CYP inhibitor

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Q

St John’s Wort

A

CYP inhibitor
Serotonin syndrome

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Q

Griseofulvin

A

CYP inhibitor

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Q

Phenobarbital

A

CYP inhibitor

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Q

Smoking

A

CYP inhibitor

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Q

Sodium valproate

A

CYP inducer
Hepatotoxic

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Q

Isoniazid

A

CYP inducer
Hepatotoxic

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Q

Cimetidine

A

CYP inducer

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Q

Ketoconazole

A

CYP inducer

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Q

Fluconazole

A

CYP inducer
Hepatotoxic

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Q

Fluoxetine

A

CYP inducer
Serotonin syndrome

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Q

Alcohol (acute)

A

CYP inducer

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Q

Amiodarone

A

CYP inducer
Hepatotoxic
QT prolongation

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Q

Chloramphenicol

A

CYP inducer

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Q

Erythromycin

A

CYP inducer

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Q

Clarithromycin

A

CYP inducer

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Q

Sulfonamides

A

CYP inducer

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Q

Ciprofloxacin

A

CYP inducer

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Q

PPIs

A

CYP inducer
Gut pH
Hyponatraemia

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Q

Metronidazole

A

CYP inducer

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Grapefruit juice

CYP inducer

Cranberry juice

CYP inhibitor

Itraconazole

CYP inhibitor Hepatotoxic

Heparin

Hepatotoxic

Paracetamol

Hepatotoxic

Ritonavir

Hepatotoxic

Tetracyclines

Hepatotoxic

Statins

Hepatotoxic

Methotrexate

Hepatotoxic Nephrotoxic Myelosuppresion/bone marrow suppression

Fluorouracil

Hepatotoxic Myelosuppresion/bone marrow suppression

Vitamin A / tretinoin

Hepatotoxic

NSAIDs

Nephrotoxic Hyperkalaemia

ACE inhibitors / ARBs

Nephrotoxic Hyperkalaemia

Cephalosporins

Nephrotoxic

Aminoglycosides (gentamicin)

Nephrotoxic Ototoxic

Lithium

Nephrotoxic

Trimethoprim

Nephrotoxic Hyperkalaemia

Vancomycin

Nephrotoxic Ototoxic

Beta-blockers

Bradycardic Hypotensive

Digoxin

Bradycardic

Dihydropyrodine CCBs (Diltiazem and verpamail)

Bradycardic Hypotensive

Ivabradine

Bradycardic

Alpha-blockers (-zosins e.g., doxazosin)

First-dose hypotension Hypotension

Dihydropyrodine CCBs (e.g., amlodipine)

Hypotensive

SGLT2 inhibitors

Hypotensive

Eplerenone

Hypotensive

Loop diuretics e.g., furosemide

Hypotensive Hypokalaemia Hyponatraemia Ototoxic

Thiazide-like diuretics

Hypotensive Hypokalaemia Hyponatraemia

Nitrates

Hypotensive

Antipscyhotics

Hypotensive QT prolongation ACB Hyponatraemia

Potassium-sparing diuretics

Hypotensive Hyperkalaemia

Parkinson's meds

Hypotensive

SSRIs

QT prolongation Antiplatelet Hyponatraemia

Methadone

QT prolongation

Anti-emetics (antihistamine)

QT prolongation

TCAs

QT prolongation Antimuscarinic/ACB Hyponatraemia

Muscarinic antagonists

ACB

MaBs

Myelosuppresion/bone marrow suppression

LMWH

Hyperkalaemia

Steroids

Hypokalaemia

Theophylline

Hypokalaemia

Antimalarials

Ototoxic QT prolonged (some)