Interleukines/Cytokines Flashcards
TNF
From: macrophages, T cells, mast cells
Function: activates endothelial cells and neutrophils, induces fever, induces acute-phase protein synthesis
IL-1
From: macrophages, DCs, endothelial cells
Function: activate endothelial cells, induce fever, induce acute-phase protein synthesis, Th17 differentiation
IL-12
From: macrophages, DCs
Function: increase activity and IFN-g production in NK/T cells, Th1 differentiation
IFN-g
From: NK/T cells
Function: activate macrophages
IL-6
From: macrophages, DCs, T cells
Function: induce acute-phase protein synthesis, proliferation of Ab producing B cells
IL-10
From: macrophages, DCs, T cells
Function: inhibition of IL-12, reduced MHC II expression, anti-inflammatory
IL-15
From: macrophages
Function: NK/T cell proliferation
IL-18
From: macrophages
Function: increase NK/T cell IFN-g synthesis
TGF-ß
From: Many cell types
Function: inhibition of inflammation, Th17 and Treg differentiation
Which two cytokines are key early signals of Septic Shock?
TNF and IL-1
IL-8
From: macrophages and endothelial cells
Function: recruits neutrophils, basophils, and T cells to site of infection
IL-4
From: Th2 and mast cells
Function: induces activation of alternative macrophage pathway (M2), Th2 differentiation, IgE isotype switching
IL-13
From: Th2 and mast cells
Function: induce activation of alternative macrophage pathway (M2), IgE isotype switching
