Interleukins Flashcards
(17 cards)
IL-1
Where?
Function?
Macrophages
Stimulation of T cells and APCs
Promotes haematopoesis
IL-2
Where?
Function?
Activated T cells
Proliferation of activated T cells
IL-3
Where?
Function?
T lymphocytes
Growth of blood cell precursors
IL-4
Where?
Function?
T cells and mast cells
B cell proliferation
IgE production
IL-5
Where?
Function?
T cells and mast cells
Eosinophil growth
IL-6
Where?
Function?
Activated T cells
Synergistic effects with IL-1 or TNFa
IL-7
Where?
Function?
Thymus and bone marrow stromal cells
Development of B and T cell precursors
IL-8
Where?
Function?
Macrophages
Chemoattracts neutrophils
IL-9
Where?
Function?
Activated T cells
Promotes growth of T cells and mast cells
IL-10
Where?
Function?
Activated B and T cells and monocytes
Inhibits inflammatory and immune responses
IL-11
Where?
Function?
Stromal cells
Synergistic effects of haematopoesis
IL-12
Where?
Function?
Macrophages and B cells
Promotes Th1 cells while suppressing Th2 function
IL-13
Where?
Function?
Th2 cells
Similar to IL-4 effects
IL-15
Where?
Function?
Epithelial cells and monocytes
Similar to IL-2 effects
IL-16
Where?
Function?
CD8 cells
Chemoattracts CD4 T cells
IL-17
Where?
Function?
Activated memory T cells
Promotes T cell proliferation
IL-18
Where?
Function?
Macrophages
Induces IFNy production
