Interstitial lung disease Flashcards Preview

Respiratory > Interstitial lung disease > Flashcards

Flashcards in Interstitial lung disease Deck (16)
Loading flashcards...
1
Q

Where do particles 1-5 um go?

A

Bifurcation of respiratory bronchioles and alveolar ducts

2
Q

Where do particles <0.5 um go?

A

Reach the alveoli and are phagocytosed by alveolar macrophages

3
Q

How does anthracosis present?

A

Asymptomatic – milde exposure, anthracotic pigment in interstitial compartment and lymph nodes

4
Q

Describe Simple Coal Worker’s Pneumoconiosis?

A

Fibrous opacities <1 cm

Upper lobes and upper portions of lower lobes

5
Q

Describe Complicated Coal Worker’s Pneumoconiosis?

A

Fibrous opacities >1 cm
With or w/o central necrosis
Black lung, massive fibrosis, possible complication Cor pulmonale

6
Q

What is the pathogenesis of Interstitial lung disease?

A

Alveolitis (damage to pneumocytes and endothelial cells) –> Leukocytes release cytokines –> stimulate interstitial fibrosis

7
Q

What are some clinical findings of Interstitial lung disease?

A

Dry cough and dyspnea
Inspiratory crackle
Cor pulmonale

8
Q

What is important to know about Silicosis?

A

Increases the risk for TB and Cancer!!

9
Q

How might someone get Berylliosis?

A

Working in nuclear and airspace industry

10
Q

Does Asbestos exposure increase your risk for TB?

A

No

11
Q

Which population does Sarcoidosis commonly affect?

A

AA, F, non-smokers, <40 yo

12
Q

How does Sarcoidosis occur?

A

Disorder of immune regulation: unknown antigen –> interaction with CD4 TH cells –> cytokine release –> recruitment of monocytes/histiocytes –> non-necrotizing granuloma formation

13
Q

What are some lab findings of Sarcoidosis?

A

Increased ACE level

Hypercalcemia

14
Q

Hypersensitivity pneumonitis

A

Type III hypersensitivity reaction

If granuloma formation then type IV response also

15
Q

Which collagen vascular diseases can lead to interstitial lung disease?

A

SLE
RA
Scleroderma

16
Q

Unexplained pleural effusion in a young woman

A

SLE!!