Interview 2 Flashcards
What is title of project?
Using Naturalistic Viewing Paradigm to Explore the Role of Conceptual Knowledge in Face Recognition’
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What is conceputal information of a face?
The conceptual information refers to person-specific details such as someone’s name, occupation, what they are as a person and personality traits like whether are they introverted or extroverted
What is perceputal information of a face?
Perceptual information of a face is information such as the arrangement of someone’s facial features of the face, the colour of someone’s eyes, and the shape of the face (i.e., does someone have a round face or sharp jaw?)
- What is the key research question you are addressing?
The main question I am trying to address is how conceptual knowledge helps in familiar face recognition and where in the brain this knowledge is represented
- Tell us about your PhD project: the research question and how you hope to investigate this/What is issue with PhD and what is your proposed methodology to investigate it? - (9)
My PhD project aims to answer the question which is how conceptual knowledge helps in familiar face recognition and where in the brain this knowledge is represented
The conceptual information refers to person-specific details such as someone’s name, occupation, what they are as a person and personality traits like whether are they introverted or extroverted
Most of the literature has focused on the role of perceptual information (i.e., visual information from someone’s face such as the arrangement of their facial features and how round their face is) in face recognition
What I would like to do with this project is investigate the role of conceptual knowledge on face recognition and there have been limited studies on this which has limitations.
Their limitation is that faces are presented in a controlled experimental setting that does not reflect our experiences in real life of how we encounter faces
The stimuli are static and are linked with artificial conceptual knowledge like name and occupation as well and perceptual and conceptual knowledge may not be separately acquired which is assumed in the paradigms as well as facial stimuli are presented in ‘trials’ that are not assumed to be independent of each other.
Naturalistic task-free paradigms can be used to overcome these limitations where participants’ neural responses are recorded in an fMRI scanner while watching an engaging movie/documentary, however, it is hard to separate conceptual from perceptual.
A recent behavioural study using naturalistic viewing paradigm by Noads and Andrews had participants watch the original or scrambled version of an episode of Life of Mars and tested how well they understood the story of the movie immediately and after a delay and performed a face recognition task. Both groups have same perceptual information but acquire different cocneputal knowledge. They found that original group performed better in constructing narrative of movie than scrambled. But interestingly, original and scrambled performed equally on face recognition task assuming they were using perceptual features for face recognition of the actors. However, after a delay of 4-week, the original group performs better than scrambled indicating use of conceptual knowledge in face recognition after delay.
Thus, our study will utilise naturalistic viewing paradigm of Noad and Andrews’s Life on Mars paradigm while participants’ neural responses are measured in fMRI and use MVPA and ISC to identify the brain network for conceptual information representation and how perceptual and conceptual networks in brain interact using dynamic causal modelling.
- What methodology of your proposed PhD project in more detail - (4)
We will use the Life on Mars naturalistic viewing paradigm (see Noad and Andrews, 2023). However, participants will initially view either the Original or Scrambled version of the movie outside the scanner which they are unfamiliar with. And they are tested on narrative using structured questions of key events of movie and write a detailed narrative.
Participants in both the Original and Scrambled groups will have the same perceptual information but will acquire different conceptual knowledge.
The neural response will then be measured in participants from both groups using fMRI. They will view a movie containing excerpts from previously unseen episodes of Life on Mars.
Participants from both groups will then be scanned after a delay of 4 weeks. On this occasion, they will view a new movie containing excerpts from previously unseen episodes of Life on Mars.
- Who developed naturalistic viewing paradigms?
Hasson et al 2004
- How using naturalistic viewing paradigm in your study overcome limitations of previous neuroimagning studies? - (4)
- The facial stimuli are dynamic and not static
- The movie is more engaging and thus might make participants more cooperative
- The perceptual and conceptual information is integrated and not separated
- The conceptual knowledge the participants learn of actors in movie is more meaningful as it goes with the story of the movie
- Why did original group in Noad and Andrews have higher face recognition performance after a delay? - (2)
This is because original group new memories of the identities of the actors are successfully consolidated over delay and their memories of new actors is enhanced as they acquired information of the actors in a coherent context which leads to them having higher face recognition of identities of actors over a longer period.
This is not the case of scrambled group as they watched the movie in scrambled order and their memories of actors they have obtained is not in a coherent context and leads to less stable recognition of them and thus leads to poor performance
- How are we defining region of interests (ROIs) in your study? - (2)
For an MVPA approach, we are not defining regions of interest apriori as we are using search light approach with MVPA as looking at the whole brain to identify brain regions which correctly classify actor’s identity above chance level.
For DCM, focusing on direction of flow of information between core and extended system. Therefore, these regions needed to be defined. To do this, we can pick up coordinates that show in ISC and MVPA analysis. Picking up those areas showing above chance classification.
- If not mentioning core and extended systems in more detail, we can say? - (2)
In core network, brain regions responsible for identifying identity of someone
In extended network, brain regions responsible for retrieval of person-specific knowledge
- How are you using MVPA in your study/whats the aim? - (3)
Using MVPA, we will ask whether the pattern of response in different regions of the brain can predict the identity of a person.
To do this, we will compare the pattern of response when one identity is viewed in one part of the video with the pattern of response from a different part of the video.
The MVPA analysis will be performed using a searchlight approach on the whole brain to identify brain regions which correctly classify identity above chance level immediately after participants watch movie and after a delay.
- What are the 2 ways to do MVPA? - (2)
region based
search light = draw 6mm sphere and run classifer sphere , contains one or more regions
- Whatis the difference between traditional univarate and MVPA?- (4)
most of the fMRI studies for face recognition use univariate method of analysis in which each voxel is considered in isolation of others while its activation in response to task or stimulus is estimated.
It is, therefore, assumed that difference in response between the two stimuli, for example, familiar vs non-familiar faces can be observed at the singe voxel level.
The possibility that information could be encoded jointly by the voxels is ignored in the univariate method.
The multivariate pattern analysis (MVPA) (Haxby et al., 2001) overcomes this limitation by considering spatially distributed pattern of activity across voxels. The MVPA makes distinctions between the stimuli or tasks based on the pattern of activity
- What is MVPA’s classifer? - (3)
A classifier is machine learning algorithm learns to associate patterns of brain activity with specific labels
Classifier is ‘trained’ on portion of dataset and told that certain brain activity correspond to different labels
The classifier is then tested on separate portion of dataset not used on training to classify in appropriate labels and its accuracy is observed
- What are the key hypotheses driving your PhD project? – MVPA- immediate: - (2)
Since immediately after the movie, both groups of participants predominantly use perceptual information for recognition, the hypothesis is that brain areas of the core network will have above chance classification in both groups and that the performance between the two groups will not be significantly different.
In contrast, brain regions from the extended network will not show above chance classification in either group
- What are the key hypotheses driving your PhD project? – MVPA- delay - (2)
Given that after a delay, there is a difference in the role of conceptual knowledge for recognition, the hypothesis is that brain areas of the extended network will have above chance classification in the Original group and that the performance will be significantly higher compared to the Scrambled group.
Since conceptual knowledge can also activate perceptual system, there will be above chance classification in the core network for Original group and this and this will not be so in the Scrambled group.
- What is inter-subject correlation? - (2)
inter-subject correlation (ISC) as a measure to calculate how consistent the activation of a given brain area across different participants is when they watch the same movie.
Mathematically, the ISC is simply a correlation coefficient between the time-series of activation extracted from a given voxel/brain area from two participants
- What is difference between inter and intra subject correlation? - (2)
Inter-subject = measures consistency of neural responses across different participants in study
Intra subject = measure consistency of neural responses within same individual across different conditions
- Why is inter-subject correlation used in naturalistic viewing paradigm? - (2)
Since the stimuli presentations in these paradigms are not controlled, a challenge lies in the analysis and interpretation of the data.
Hasson et al (Hasson et al., 2004) used inter-subject correlation (ISC) as a measure to calculate how consistent the activation of a given brain area across different participants is when they watch the same movie.
- How are you using ISC/whats your aim? - (2)
The second aim of the proposal is to use Inter-subject correlation (ISC) to assess the role of conceptual information in face identification
To address this question, the neural response to the movies shown without a delay and with a delay will be compared in participants from the Original and Scrambled groups.
- What are the key hypotheses driving your PhD project? – ISC – delay and immediate: - (4)
Since immediately after the movie, both groups of participants predominantly use perceptual information for recognition, the hypothesis is that brain areas of the core network will have high ISC in both groups and that the performance between the two groups will not be significantly different.
In contrast, brain regions from the extended network may not show high ISC in either group.
Given that after a delay, there is a difference in the role of conceptual knowledge for recognition, the hypothesis is that brain areas of the extended network will have higher ISC in the Original compared to the Scrambled group.
Since conceptual knowledge can also activate perceptual system, there may also be higher ISC in the core network for Original group.
- What is the aim of DCM and how it is used - (2)
The third aim is to understand causal interactions between the core and extended network using dynamic causal modelling (DCM) for fMRI
More specifically, the hypotheses to be tested are (i) the flow of information between core and extended network is influenced by conceptual knowledge and (ii) the flow of information has its directionality from extended to core network