intestinal tox

Question 1

what are the three main functions of the intestine, and what structures help with this

Question 2

what are two secondary functions of the small intestine, and what structures help with this

Question 3

what are the 7 main cells of the small intestine epithelium

Question 4

function of the enterocytes

Question 5

function of the goblet cells

Question 6

function of the paneth cells

Question 7

function of the neuroendocrine cells

Question 8

function of the stem cells

Question 9

function of the M cells

Question 10

function of the dendritic cells

Question 11

what is the indirect mechanism by which the gut is involved in xenobiotic metabolism

Question 12

what is the DIRECT method by which the gut is involved in xenobiotic metabolism

Question 13

what are the different sites of drug first pass metabolism

Question 14

how can you obtain microbiome data

Question 15

why is the gut so susceptible to toxic insult

Question 16

what causes barrier dysfunction

Question 17

what are examples of enviro toxins, dietary factors, and intestinal diseases that can cause barrier dysfunction

Question 18

describe the healthy state of the microbiota (4)

Question 19

what happens to the microbiota in the disease state (7)

Question 20

describe the structure of H pylori

Question 21

where do h pylori colonize; what does this lead to

Question 22

how can you treat h pylori infection

Question 23

what does persistant h pylori infection cause

Question 24

how does h pylori prevalence in canada compare with prev in nunavik inuit population

Question 25

how does h pylori lead to the development of ulcers

Question 26

what three traits help h pylori infection occur

Question 27

what is the role of CagA and VacA and how are they involved in h pylori infection

Question 28

t/f: antibiotics have no side effects

Question 29

how do antibiotics affect the gut microbiota

Question 30

how does early life LDP impact the microbiota

Question 31

t/f: artificial sweeteners are absorbed in the body due to their structure

Question 32

are artificial sweeteners metabolically inert or active ; why?

Question 33

animal models suggest that artificial sweeteners are metabolized where?

Question 34

how did artificial sweeteners impact epithelial barrier of Caco-2 cells. what receptor attenuates this permeability?

Question 35

what are some environmental factors contributing to intestinal barrier impariment

Question 36

what are some systemic diseases that result form intestinal barrier impairment

Question 37

t/f: microbiota dysbiosis is a standalone disease, and is not involved in the development of other diseases