Intoxications and Infections of Nervous System

Question 1

tetanus binds

Answer 1

interneurons

Question 2

tetanus prevents release of which neurotransmitters

Answer 2

inhibitory neurotransmitters - glycine and GABA

Question 3

generalized tetanus can give what sx besides generalized muscle spasms

Answer 3

generalized convulsive seizures

Question 4

arching back for tetanus

Answer 4

opisthotonus

Question 5

neutralize remaining tetanospasmin via

Answer 5

tetanus Ig

Question 6

botulism exotoxin binds ___ and prevents release of ___

Answer 6

binds presynaptic nerve terminals

prevents ACh release

Question 7

oral drug to facilitate ACh release and improve strength (can use for botulism)

Answer 7

Guanidine

Question 8

peipheral neuropathy and wrist drop in adults

encephalopathy and ab pain in kids

Answer 8

lead poisoning

Question 9

tx for CO poisoning

Answer 9

100% oxygen or hyperbaric chamber

Question 10

a few weeks after CO poisoning, pts may show signs of ____

Answer 10

parkinsonism

Question 11

nystagmus, opthalmoplegia, gait ataxia, and confusion

Answer 11

Wernicke’s encephalopathy (thiamine/B1 deficiency)

Question 12

petechial rash is highly suggestive of which meninigits

Answer 12

Neisseria

Question 13

initial abx for meningitis

Answer 13

ceftriaxone + vanco

Question 14

add which abx for elderly or neonates to cover for listeria meningitis

Answer 14

ampicillin

Question 15

what else do you give adults w/ meningitis besides abx

Answer 15

IV dexamenthasone (.15 mg/kg)

Question 16

what type of wbcs for bacterial meningitis

Answer 16

PMNs

Question 17

check for herpes encephalitis via

Answer 17

CSF PCR

Question 18

tx for herpes encephalitis

Answer 18

IV acyclovir

Question 19

tx for shingles

Answer 19

acyclovir or similar antiviral

Question 20

confirm clinical dx of PML via

Answer 20

positive PCR assay for JC virus in CSF or typical brain biopsy findings

Question 21

periodic sharp waves on EEG seen w/

Answer 21

CJD