intracellular enzymatic toxins Flashcards
(12 cards)
toxins that ADP ribosylate regulators of adenylate cyclase
cholera toxin, E. coli enterotoxin, pertussis toxin
effect of ADP ribosylating enzymes on adenylate cyclase
disturbed cAMP levels = abnormal signal transduction and ion balance
effect of diptheria toxin
ADP-ribosylates elongation factor 2 = inhibits translation
bacteria that produce adenylate cyclase analogues as toxins
bordetella pertussis (whooping cough) and bacillus anthrax
effect of adenylate cyclase analogue toxins
disturb cAMP levels, hence abnormal signal transduction and ion balance
what type of enzyme is shiga toxin
glycosidase
what does shiga toxin do
dupurinates rRNA and blocks protein synthesis
what do colstridium difficile toxins do
glucosylate small GTPases (Rho / Ras) involved in signal transduction - disrupt actin cytoskeleton hence tight junctions
which types of bacteria produce cytolethal distending toxins
salmonella typhi, E. coli
what do cytolethal distending toxins do
genotoxins. they cleave DNA
what toxin does UPEC produce
cytotoxic necrotizing factor
what does cytotoxic necrotizing factor fo
a deamidase that targets host cell GTPases, disrupting signal transduction
