Intrinsic Resistance Flashcards

1
Q

Aerobic GNR (2)

A

Clindamycin

Vancomycin

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2
Q
Non-glucose-fermenting GNR:
Pseudomonas (oxidase +)
Burkholdereria (oxidase +)
Acinetobacter (oxidase -)
Stenotrophomonas (oxidase -)
(1)
A

Ertapenem

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3
Q

Burkholderia cepacia complex (

A
Penicillins
1st and 2nd generation cephalosporins
Cephamycins
Ertapenem
Colisitn
Fosfomycin
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4
Q

SPICE organisms

A
(chromosomal AmpC betalactamase)
Penicillins (except piperacillin)
Amp/sulbactam
Amox/clav
1st/2nd gen cephalosporins, cephamycins

Exposure -> de-repression of ampC gene and resistance to:
3rd gen cephalosporins
Pip/tazo
Ertapenem

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5
Q

Citrobacter freundii complex

A

SPICE (de-repressible chromosomal Amp-C)

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6
Q

Citrobacter koseri

A

Ampicillin
Piperacillin
Ticaricillin

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7
Q

Enterobacter

Klebsiella aerogenes

A

SPICE

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8
Q

Klebsiella (not aerogenes)

A

Ampicillin

Ticarcillin

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9
Q

Proteae (Proteus, Morganella, Providencia)

A
Colistin
Nitrofurantoin
Tetracycline/tigecycline
Imipenem
SPICE
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10
Q

Pseudomonas aeroginosa

A
Ampicillin
Amp/sulbactam
1st/2nd gen cephalosporins
Cephamycins
Ceftriaxone
Ertapenem
Trimethoprim-sulfamethoxazole
Nitrofurantoin
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11
Q

Salmonella/shigella

A

Aminoglycosides

1st/2nd generation cephalosporins and cephamycins

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12
Q

Serratia marcescens

A

Nitrofurantoin
Colistin
SPICE

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13
Q

Stenotrophomonas maltophila

A
Penicillins
Amp/sulbactam
Amox/clav
Pip/tazo
1st-3rd generation cephalosporins except ceftazidime
Cephamycins
Aztreonam
Carbapenems
Aminoglycosides
Tetracycline
Fosfomycin
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14
Q

Aerobic GP organisms

A

Colistin
Polymixin B
Nalidixic acid

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15
Q

Enterococcus

A

Cephalosporins
Aminoglycosides
Clindamycin
Trimethoprim-sulfamethoxazole

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16
Q

E. faecalis

A
Cephalosporins
Aminoglycosides
Clindamycin
TMP/SMX
Quinupristin/dalfopristin
17
Q

E. casseliflavus and gallinarum

A
Cephalosporins
Aminoglycosides
Clindamycin
TMP/SMX
Quinupristin/dalfopristin
Vancomycin
18
Q

Listeria

A

Cephalosporins

19
Q

SPICE organisms

A
Serratia spp
P. aeruginosa
Indole-positive proteae: Proteus vulgaris, providencia, morganella morganii
Citrobacter freundii
Enterobacter spp
20
Q

Colisitn-resistance (in GN - most GP are R) - 6

A

Burkholderia
Neisseria gonorrheae and meningitidis
Protea (proteus, providencia, morganella)
Serratia

Inquilinus limosus (seen in CF)
Pandoreaea (CF)
21
Q

Vancomycin resistance (in GP - most GN are R) - 7

A

Clostridium innocuum
Enterococcus gallinarum and casseliflavus (chromosomal vanC)
Erysipelothrix rhusiopathiae
Lactobacillus (except acidophilus and delbrueckii)
Leuconostoc
Pediococcus
Weissella