Intrinsic Resistance Flashcards
Aerobic GNR (2)
Clindamycin
Vancomycin
Non-glucose-fermenting GNR: Pseudomonas (oxidase +) Burkholdereria (oxidase +) Acinetobacter (oxidase -) Stenotrophomonas (oxidase -) (1)
Ertapenem
Burkholderia cepacia complex (
Penicillins 1st and 2nd generation cephalosporins Cephamycins Ertapenem Colisitn Fosfomycin
SPICE organisms
(chromosomal AmpC betalactamase) Penicillins (except piperacillin) Amp/sulbactam Amox/clav 1st/2nd gen cephalosporins, cephamycins
Exposure -> de-repression of ampC gene and resistance to:
3rd gen cephalosporins
Pip/tazo
Ertapenem
Citrobacter freundii complex
SPICE (de-repressible chromosomal Amp-C)
Citrobacter koseri
Ampicillin
Piperacillin
Ticaricillin
Enterobacter
Klebsiella aerogenes
SPICE
Klebsiella (not aerogenes)
Ampicillin
Ticarcillin
Proteae (Proteus, Morganella, Providencia)
Colistin Nitrofurantoin Tetracycline/tigecycline Imipenem SPICE
Pseudomonas aeroginosa
Ampicillin Amp/sulbactam 1st/2nd gen cephalosporins Cephamycins Ceftriaxone Ertapenem Trimethoprim-sulfamethoxazole Nitrofurantoin
Salmonella/shigella
Aminoglycosides
1st/2nd generation cephalosporins and cephamycins
Serratia marcescens
Nitrofurantoin
Colistin
SPICE
Stenotrophomonas maltophila
Penicillins Amp/sulbactam Amox/clav Pip/tazo 1st-3rd generation cephalosporins except ceftazidime Cephamycins Aztreonam Carbapenems Aminoglycosides Tetracycline Fosfomycin
Aerobic GP organisms
Colistin
Polymixin B
Nalidixic acid
Enterococcus
Cephalosporins
Aminoglycosides
Clindamycin
Trimethoprim-sulfamethoxazole
E. faecalis
Cephalosporins Aminoglycosides Clindamycin TMP/SMX Quinupristin/dalfopristin
E. casseliflavus and gallinarum
Cephalosporins Aminoglycosides Clindamycin TMP/SMX Quinupristin/dalfopristin Vancomycin
Listeria
Cephalosporins
SPICE organisms
Serratia spp P. aeruginosa Indole-positive proteae: Proteus vulgaris, providencia, morganella morganii Citrobacter freundii Enterobacter spp
Colisitn-resistance (in GN - most GP are R) - 6
Burkholderia
Neisseria gonorrheae and meningitidis
Protea (proteus, providencia, morganella)
Serratia
Inquilinus limosus (seen in CF) Pandoreaea (CF)
Vancomycin resistance (in GP - most GN are R) - 7
Clostridium innocuum
Enterococcus gallinarum and casseliflavus (chromosomal vanC)
Erysipelothrix rhusiopathiae
Lactobacillus (except acidophilus and delbrueckii)
Leuconostoc
Pediococcus
Weissella
