Intro to Antiarrhythmic Drugs

Question 1

General mechanism of Class I drugs?

Answer 1

Na+ Channel Blockade

-Alters AP duration & kinetics or Na+ channel blockade

Question 2

General mechanism of Class II drugs?

Answer 2

Beta-Adrenoreceptor Blockade

-Blockade of SNS effects in the heart

Question 3

General mechanism of Class III drugs?

Answer 3

K+ channel blockade

-Prolongation of the effective refractory period

Question 4

General mechanism of Class IV drugs?

Answer 4

Ca2+ Channel blockade

-Slows conduction where depolarization is Ca2+ dependent

Question 5

What are the three groups of Na+ channel blockers?

Answer 5

Subgroup IA, IB, IC

Question 6

What are the Na channel blockers subgroup IA?

Answer 6

• Quinidine
• Procainamide
• Disopyramide

Question 7

What are the Na channel blockers subgroup IB?

Answer 7

• Lidocaine
• Mexilitine
• Tocainide (not USA)

Question 8

What are the Na channel blockers subgroup IC?

Answer 8

• Flecainide
• Propafenone
• Moricizine (not USA)

Question 9

What are the K+ Channel Blockers?

Answer 9

• Amiodarone
• Dofetilide
• Ibutilide

Question 10

What are the Ca2+ Channel Blockers?

Answer 10

• Verapamil

- Diltiazem

Question 11

What are the Beta-Adrenergic Blockers?

Answer 11

• Propranolol
• Acebutolol
• Esmolol
• Sotalol

Question 12

What are the Misc. Antiarrhythmatics we should know?

Answer 12

• Adenosine

- Digitalis