Intro to Derm Flashcards

(108 cards)

1
Q

Dermis

A
  • Connective tissue (collagen and elastin)
  • Blood supply
  • Nerve supply
  • Contains pilosebaceous, apocrine and eccrine structure
  • Cellular components: Fibroblasts, mast cells/macrophages, enzymes
  • Layers: Reticular (strength, structure elasticity) and - Papillary (supplies nutrients to epidermis, regulates temp)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Epidermis Layers

A
  • Stratum basale (basemnet menbrane)
  • Stratum spinosum
  • Stratum granulosum
  • (Stratum lucidum)
  • Stratum corneum (surface layer, dead keratinocytes)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Melanocytes

A
  • Sandwiched between keratin forming cells in basal layer
  • Make pigment
  • Major component of melanocytic nevi
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Merkel cells

A
  • Located in basal layer

- Help with touch sensation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Langerhans cells

A
  • Immune cells scattered throughout the epidermis

- Antigen presenting/ recognition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Appendages

A
  • Cornified (Hair, nails)
  • Arrector Pilli (muscle connected to hair to stand it up)
  • Glandular (Sebaceous- make sebum, Apocrine- pharemones, Eccrine- make sweat)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Macule

A

Flat lesion <1 cm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Patch

A

Flat lesion >1 cm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Papule

A

Raised lesion < 1 cm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Plaque

A

Raised lesion >1 cm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Nodule

A

Raised lesion, firm to the touch, deep seeded

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tumor

A

Swelling caused by abnormal growth of tissue either benign or malignant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Vesicle

A

raised, serous (clear) fluid filled, < 1 cm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Bulla

A

Serous filled lesion > 1 cm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Wheal

A

Area of edema within the skin, irregularly shaped, transient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Pustule

A

Pus filled, raised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Scale

A

thin flake of dead exfoliated epidermis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Excoriation

A

linear or punctuate erosions caused by scratching

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Fissure

A

A linear crack in the skin often resulting from excessive dryness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Crust

A

Dried residue of skin exudates such as serum, pus, or blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Erosion

A

non-scarring loss of superficial epidermis. Surface is moist but does not bleed. Ruptured vesicle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Ulcer

A

Deeper loss of epidermis and dermis. May bleed and scar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Scar

A

connective tissue that arises from injury (keloid- hypertrophic scarring that extends beyond the initial injury)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Atrophy

A

Thinning of the dermis or epidermis causing depression in the skin (Atrophic scar- thinning, sunken in scar)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Petechiae
small flat red lesions caused by intradermal hemorrhage (< 3 mm), non-blanchable
26
Purpura
purplish-red hemorrhagic area in the skin (> 3mm) non-blanchable. Related to clotting disorders, thrombocytopenia
27
Ecchymosis
Bruise, bluish-purple, caused by leakage of blood from ruptured vessels (trauma)
28
Lichenification
Visible and palpable thickening of the epidermis and roughening of the skin with increased visibility of the skin furrows
29
Telangestasia/telangectases
fine, irregular dilated blood vessels that blanch w pressure
30
Maceration
Wetness, white softness to skin (like in pool for a long time)
31
Burrows
Like scabies/lice. Go into skin
32
Annular
Round
33
Linear
In a line
34
Target (Iris)
Bullseye
35
Serpiginous
Serpant-like (can be from parasite)
36
Geographic
Shaped like a map
37
Arciform
Arch
38
Guttate
droplet-like
39
Polycyclic
multiple rings within structure (tinnea corpus)
40
Koebnerization
when have skin disease if scratch enough can cause new plaques to form in scratched areas
41
Seborrheic keratosis dx
- Warty/ verrucous/ scaly stuck on appearance - benign - epidermal tumor - Males=females, age>30 - color --> any! - Size varies - Dermatosis papulosa nigra: Seen in African American, smaller/darker papules on cheeks - Stucco keratoses: White papules seen on legs - Sign of Leser-Trelat: Can indicate an internal malignancy (breast, lung, bone marrow, stomach, uterus
42
Seborrheic keratosis tx
- Don't have to be treated if asymptomatic (Benign) - Cryotherapy - Electrodessication and curettage (electric current coagulates top layer. scrape off)
43
Acrochordons dx
- aka skin tags - Benign - Pedunculated soft tumors - females>males, >age 30 - Neck, axillae, groin most frequently - Normal skin color, pink, tan - size 1-3mm - menopause - obesity-metabolic syndrome - Pregnancy - Many skin tags may indicate a possible correlation with intestinal polyps (familial adenomatous polyposis- internal polyps that can turn into colon cancer)
44
Acrochordons tx
- Benign - Scissor removal - Electrocaudery - Cryotherapy (don't recommend, causes too much collateral damage)
45
Scars dx
- Benign - Secondary to injury or disease - Pock mark, ice pick - Hypertrophic, keloid (more likely in those with African ancestry)
46
Scars tx
Pock mark, ice pick: - Dermabrasion - Synthetic fillers - Chemical peels Hypertrophic, keloid (more likely in those with African ancestry): - Scar massage - Intralesional steroid injection - Pulse dye laser - Silicone products
47
Dermatofibroma dx
- Benign - Can be due to trauma - Scar tissue type growth - Seen in adults and less common children - Legs>arms>trunk - Females>males - Firm fibrotic papule - Any color - Dimples with lateral pressure - Size 3-10mm
48
Dermatofibroma tx
- Cryotherapy (usually need more than 1 tx) | - Punch biopsy (excision)
49
Sebaceous hyperplasia dx
``` Benign Hypertrophy of the oil glands Common as we get older, lighter skin individuals (? Oily skin individuals) Seen on the face Lobulated, umbilicated papules Skin color, pink, red (when inflamed) Size 1-4mm ```
50
Sebaceous hyperplasia tx
Not necessary unless irritating | Electrocautery (tell patient they have a high chance of growing back)
51
Syringoma dx
Benign (modified sebaceous hyperplasia but flatter) Onset puberty, mostly women, may be familial and is seen in Down Syndrome Eyelids, axillae, chest, umbilicus, anterior thighs and vulva Yellowish papules and there are many Size 1-2mm
52
Syringoma tx
Electrocautery
53
Milium/Milia dx
Benign (Small epidermal cyst, often around eyes) Trauma, certain dermatoses, skin care habits, health conditions, UV exposure, or no known cause Epithelial buds Face, neck, chest White, light-yellow firm papules Size 1-2mm
54
Milium/Milia tx
Retinoids (treat and prevent) Incision and extraction Light electrodessication
55
Epidermal cyst dx
``` Benign From epidermis/epithelium of the hair follicle Face, neck, trunk Soft, mobile nodules Cyst contents=not pleasant! Size O.5-5.0 cm ```
56
Epidermal cyst tx
Excision | Incision and drainage not effective
57
Pilar cyst dx
``` Benign Occur on scalp Females>males, familial Patients tend to have many Will lose hair Size 0.5-5.0cm ```
58
Pilar cyst tx
Excision | Incision and drainage not effective
59
Myxoid cyst dx
(aka mucous or synovial cyst) Benign Dorsal surface of a finger, less often toes Perhaps related to osteoarthritis Single, soft to rubbery nodule Has gelatinous/viscous material within it (filled with jt fluid) Overlying skin normal or can be warty/filiform projections Size 2-5mm
60
Myxoid cyst tx
Surgically excised I & D followed by firm compression dressing for weeks Injection of sclerosing solution Triamcinolone injection
61
Pilonidal cyst dx
Benign Develops over tailbone/near top of gluteal cleft Contains hair and skin debris Asymptomatic or symptomatic Men>women, Caucasians, ages 15-24, +FmHx, hirsute individuals, deep natal cleft Excessive/repetitive trauma to this area will increase risk for development or rupture of existing cyst
62
Pilonidal cyst tx
``` Incision and drainage Pack the wound if deep with frequent dressing changes in the office Antibiotics generally not needed Pain relief Recurrent cysts=general surgery ```
63
Mucoceles dx
(pseudocyst- bite inner cheek, bluish soft nodule) Collections of mucin following rupture of a minor salivary gland duct Blue tinted, translucent, soft nodules, asx
64
Mucoceles tx
Incise and drain
65
Fordyce spots dx
(yellow spots on lips Ectopic sebaceous glands on the oral mucosa Pinhead-sized white-yellow spots on the oral mucosa
66
Fordyce spots tx
Biopsy to rule out other disease processes i.e. squamous cell carcinoma No tx necessary
67
Lipoma dx
``` Benign Neoplasm of subcutaneous tissue Solitary or multiple round, lobulated, yellow masses Well circumscribed No overlying skin change Scalp, neck, trunk, UE’s and LE’s ```
68
Lipoma tx
(nothing has to be done with them) | Excision (VERY small amount can become cancerous)
69
Pyogenic granuloma dx
Benign Usually follows minor trauma Vascular proliferation (without infection) Fingers, lips, mouth, trunk, toes Red vascular papule, with or without crusts/erosions “Positive band aid sign” Size 1-4mm
70
Pyogenic granuloma tx
(Don't want to leave these. Tend to bleed. Send to pathology) Shave biopsy with cauterization
71
Stork bite dx
``` Dilated capillaries in the superficial dermis Occurs 50% of all babies Posterior neck, forehead, eyelids Persistent, faint, red patch Size several centimeters ```
72
Stork bite tx
Not necessary on posterior neck | Facial ones do fade over time
73
Port wine stain (aka nevus flammeus) dx
Dilated dermal capillaries Face or trunk, less often extremities Pink-purple macules/patches Size can be several centimeters Can be hardly there to severely disfiguring Port wine located over the trigeminal area Think Sturge-Weber Syndrome (malformation of leptomeninges-epilepsy, hemiparesis, glaucoma) Port wine stain involving a limb think: Klippel-Trenaunay Syndrome (underlying venous malformation) Parkes-Weber Syndrome (arteriovenous fistulae seen)
74
Port wine stain (aka nevus flammeus) tx
Send to pediatric dermatologist PDL Make up can be used to camouflage
75
Infantile hemangiomas dx
Superficial hemangioma - Most common tumor of infancy - More common in females than males, 3:1 - Soft, bright red to deep purple, compressible nodule or plaques (50% on head, 25% trunk) - Size 1-8 cm - Fast growth first year (80% of their size at 3 months) - Will turn grayish-white - End result: slight atrophy, depigmentation, telangiectasia, scarring - Regression complete by age 5 in 50% of children; 90% by age 9 Deep hemangioma - Same “pattern” as superficial hemangiomas - Lower dermis/subcutaneous fat - Rubbery mass of bluish color with overlying telangiectases - Can be combined with superficial hemangioma - Does not involute as well as superficial type
76
Infantile hemangiomas tx
(for both deep and superficial hemangiomas) Send to pediatric dermatologist Pulse dye laser or continuous wave laser Intralesional and systemic high-dose glucocorticoid Propranolol (worry about hypotension, hypoglycemia, bronchospasm, hyperkalemia) Interferon-alpha Cryosurgery Excision 5 or more hemangiomas evaluate for liver hemangiomas Hemangioma covers face it may be associated with neurologic, ophthalmologic and cardiac abnormities (PHACE Syndrome) The above seen, send to pediatric dermatology
77
Cherry angiomas dx
(superficial blood vessels, ok, normal) Dilated capillaries Common as we mature, more so in fairer skin individuals Scalp, face, trunk, extremities Mostly red in color, sometimes dark purple Size 1-3mm
78
Cherry angioma tx
(Should biopsy if just one) Electrocautery Laser/intense pulse light
79
Spider angioma/ telangectasia(es) dx
(superficial blood vessels coming to surface of skin and then branching) Spider angioma: Dilated radiating capillaries surrounding a central arteriole Telangiectases: Small “broken capillaries” Face, forearms, hands Spider angiomas: Under diascopy the radiating telangiectases will blanch; the center will not Red in color Size: up to 1.5cm More often in females Hyperestrogenic states Liver disease Young children Multiple lesions: Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu Syndrome) Ataxia-telangiectasia Telangiectasia seen in systemic scleroderma, rosacea, sun damaged skin
80
Spider angioma/ telangectasia(es) tx
Electrocautery | Laser surgery
81
Angiokeratomas dx
``` Capillary dilation in the papillary dermis Most often on scrotum and vulva Can have many lesions, >100 Red, purple, blue in color Size 2-4mm ```
82
Angiokeratomas tx
Not needed | Uncertain of diagnosis --> biopsy it
83
Venous lake dx
``` Dilated venule Common in patients >50 y/o ? Related to sun exposure Face, lips, ears most common Dark blue or purple papule Size 3-6mm Will blanch under diascopy ```
84
Venous lake tx
Electrosurgery Laser Rarely, excision
85
Melanocytic nevus (nevi) dx
aka birthmark/mole Localized benign tumors of melanocytes Classified by age of onset - Acquired versus congenital Classified by arrangement of these tumors within skin layers - Junctional, compound, intradermal More common in lighter skinned individuals
86
Melanocytic nevus (nevi) tx
Benign
87
Acquired melanocytic nevus dx
``` Benign proliferations of normal skin components Occur from scalp to soles Can be macular or papular Tan to brown Size 1-6mm ``` Junctional - Arise from dermo-epidermal junction - Macular - Common in childhood - Face, arms, legs, trunk, palms and soles Compound - Collection of melanocytic cells in the epidermis and dermis - The “in between stage” of junctional and intradermal nevi - Less pigmented than junctional nevi - More papular Intradermal or Dermal - Nevus is totally within the dermis - No color - Papular
88
Acquired melanocytic nevus tx
Shave biopsy Punch biopsy/removal Elliptical excision Dermascope can help aid in deciding to remove lesion or monitor Will remove if it looks unusual or has a history of repetitive trauma, any symptoms or h/o change Large numbers of nevi can be a genetic risk factor for melanoma Total body skin checks are a must! Sun protection measures need to be taught Teach ABCDE method to monitor moles
89
Atypical melanocytic nevus dx
These present differently than your typical nevus More common in fair skin individuals Can occur on any part of the body Borders are notched, irregular, ill-defined Can have a macular appearance +/- center that is papular Color ranges from tan, brown, black, red, pink Size 5-15mm Those with many of these lesions=higher risk for melanoma (10 or more have 12 times the risk for melanoma vs. general population) This risk increases if there is a +FMHx for melanoma
90
Atypical melanocytic nevus tx
``` Biopsy if it resembles no other Total body skin check by a dermatology provider Teach sun protection measures Teach the ABCDE’s Discouraged intentional tanning ```
91
ABCDE's
``` Asymmetry Border irregularity Color variegation Diameter, >6mm Evolution ```
92
Sun protection measures
``` Minimize sun exposure Sun protective clothing Sun protectant lotion >30 SPF Hats ```
93
Congenital melanocytic nevus dx
``` Deeper in the dermis and subcutaneous fat Noted at birth/ first few years of life Occur anywhere Evenly pigmented papules/plaques Can have a pebbly surface Can be associated with hair follicles Tan, brown, array of colors ``` These lesions have malignant potential 1.5cm have less than 0.5% risk 1.6-20cm have a 3.3-6.0% risk >20cm have a 10% risk
94
Congenital melanocytic nevus tx
Have to monitor on a regular basis by derm If it looks abnormal = biopsy Any changes = biopsy Educate about sun protection measures
95
Becker’s nevus dx
(Single giant nevus) Increase number of basal melanocytes (no nevus cells in dermis) Melanosomes increased in keratinocytes Increased number of testosterone receptors Back, shoulder, submammary Large, focal, brown, hair-bearing verrucous plaque or brown patch at onset >10 cm
96
Becker's nevus tx
None needed unless for cosmetic reasons
97
Nevus spilus dx
``` ("Frog spawn nevus") Late infancy or early childhood Trunk, UE’s, LE’s Tan to light brown patches with 1-2mm brown-dark brown macules and/or papules “sprinkled” throughout Size few centimeters to >15cm ```
98
Nevus spilus tx
None | Cosmetic reason: surgical excision, laser
99
Nevus sebaceous dx
Scalp, face, neck Pebbly, velvety, or warty surface Can be flat at birth Yellow to orange in color Size 1-3cm Associated with basal cell and squamous cell carcinomas Large lesions can be associated with “neurocutaneous syndrome” of epilepsy, mental retardation, eye and skeletal defects
100
Nevus sebaceous tx
Excise-refer to dermatology
101
Halo nevus dx
Immunologic phenomena Pre-existing melanocytic nevus that is encircled by depigmentation Can occur to any melanocytic nevus on any part of the body Perhaps the ”calling card” for future development of vitiligo Can be seen in metastatic melanoma (halo forms around mets and the primary lesion)
102
Halo nevus tx
Need to evaluate skin for vitiligo and suspicious nevi Biopsy Refer to dermatology for monitoring/ rule out melanoma
103
Blue nevus dx
``` Due to melanocytes in the dermis Face, scalp, back, hands, feet Macules or papules, round and oval in shape Blue, blue-gray, blue-black Size <10mm ```
104
Blue nexus tx
Excise, send to derm
105
Spitz nevus dx
``` Most often occurs in pre-adolescence Rare in >40 y/o Dome-shaped, hairless papule Face, scalp Pink, tan, brown Size <10mm Microscopically looks close to melanoma ```
106
Spitz nevus tx
Excision | Send to dermatology for skin evaluation
107
Café au lait spot dx
Increase in melanin with giant melanosomes Tan to brown patches Common in African Americans>Hispanics>Caucasians Males=Females Present at birth or within 2-3 years Associated with neurofibromatosis and other syndromes (tuberous sclerosis, ataxia telangiectasia)
108
Café au lait spot tx
None if there is no suspicion of another disorder