Intro to pharm Flashcards

(37 cards)

1
Q

NURSING PROCESS

A

There are 5 steps to the nursing process
1. Assessment
2. Nursing Diagnosis
3. Planning
4. Interventions/Implementation
5. Evaluation

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2
Q

Nursing Process (2)

A

-Assessment
-Subjective data
-Current health history
-Client symptoms
-Current medications
-Past health history
-Client’s environment
-Primary language and communication needs

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3
Q

Nursing Process (3)

A

-Assessment
-Objective data
-Physical assessment (VS, physical exam)
-Laboratory tests (CBC, kidney/liver function, etc)
-Diagnostic studies (MRI’s, CTscans, etc)

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4
Q

Nursing Diagnosis

A

-Formula:
Nursing diagnosis…..related to (R/T)…….as evidenced by (AEB)……

-Common nursing diagnoses related to drug therapy
-Deficient knowledge about drug action, administration, and side effects related to cultural/language barrier
-Ineffective health maintenance related to forgetfulness
-Injury, risk for r/t side effects of drug

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5
Q

Goals

A

-Characterized by goal setting (or expected outcomes)
-Example: Client EV will independently administer prescribed dose of albuterol by the end of the first session of instruction

-Characteristics of a goal:
Client Centered
Realistic and measurable (quantifiable)
Realistic deadlines (timeframe)

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6
Q

Interventions/ImplementationGuiding the patient

A

-Nursing actions (interventions) necessary to accomplish the goals (outcomes)
-Client teaching
-General
-Self-administration
-Diet
-Side effects
-Cultural considerations

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7
Q

Evaluation

A

-Ongoing and related to progress and goal achievement
-Related to achievement of goals; if not met, reassess and continue
-Determine need for follow-up
-Refer to community resources

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8
Q

Checklist for Health Teaching in Drug Therapy

A

-Comprehensive drug and health history
-Reason for medication therapy
-Expected results
-Side effects and adverse reactions
-When to notify health care provider or pharmacist
-Drug-drug, drug-food, drug-laboratory, drug-environment interactions

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9
Q

Right’s of Drug Administration

A

1.Right client
2. Right drug
3. Right dose
4. Right time
5.Right route
6.Right documentation

Right reason
Client’s right to refuse

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10
Q

Safety in Medication Administration

A

Medication errors can result in; serious illness, conditions that prolong hospitalization or require additional treatment, or death.

Common medication errors include:
Giving an incorrect dose
Not giving an ordered medication
Giving an unordered medication

Culture of Safety
Institute of Medicine Report (1999)
To Err Is Human: Building a Safer Health Care System
Bar Code
Computerized prescriber order entry
The Joint Commission (2005)
Evidenced-based nursing – obtaining and analyzing the best scientific research to promote high-quality care to clients

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11
Q

Drug order components

A

-Date and time order is written
-Drug name
-Drug dosage
-Route of administration
-Frequency and duration of administration
-Any special instructions for withholding or adjusting dosage based on nursing assessment, drug effectiveness or labs
-Physician or other HCP’s signature (PROVIDER)
-Signature of licensed practitioner taking TO or VO

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12
Q

Disposal of Medications

A

Proper disposal of medications

-Follow specific information on drug label or insert
-Do not flush drugs down toilet unless specifically instructed
-Transfer drug from original container to undesirable substance (i.e. narcotics in kitty litter)
-Return drugs to community “drug take-back” program
-Remove all identifying information on container
-Consult pharmacist

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13
Q

Routes of administration of drugs

A

Sublingual (under tongue)
Buccal (between cheek & gums)
Oral (PO)
Transdermal (patches)
Topical (cream, ointments)
Instillation (sprays –aerosol, mouth; drops – ear, eye)
Inhalations
Enteral (Nasogastric and gastrostomy tubes)
Suppository (vaginal, rectal)
Parenteral (intradermal, subcutaneous, intramuscular & intravenous)
Intravenous (IV)
Subcutaneous (SQ)
Intramuscular (IM)

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14
Q

Medication Orders

A

MUST include:
-Patient’s full name
-Full name of drug (not initials)
-Dose
-Route
-Frequency
-Time, date, & signature of prescriber

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15
Q

Order examples

A

Good example:
-Zofran 4mg IV every(Q) 4 hours PRN

Bad examples:
-MS 4mg IV Q 2 hrs PRN
-Tylenol 650mg PO PRN
-Azithromycin IV Q 12 hrs

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16
Q

Pharmacology

A

-Effectiveness & usefulness
-Safety: ? 100%
-Selectivity & ability to illicit wanted response
-Predictable
-Ease of administration
-Freedom from drug interactions
-Low cost
-Chemically stable
-All have generic (small case: valacyclovir) & trade name (capitalized: Valtrex)

17
Q

Drug Classifications and Drug Names

A

How to use a Nurse’s Drug Guide
Look up the drug Aspirin;
trade name Mechanism of Action (MOA)
generic name Dosage
classification Contraindications
Pregnancy category Adverse Effect
Adverse Reaction

18
Q

Drug

A

Drug: Any chemical that can affect processes

19
Q

Pharmaceutic Phase (Dissolution)

A

-First phase of drug action
-Solid drugs or tablets disintegrate in the process of dissolution to allow for absorption
-Liquid drugs more readily available for absorption by the body
-Acidic fluids tend to enhance disintegration and absorption
-The decrease in the acidic gastric environment of the young and old often decrease rate of drugs absorbed in the stomach
-Enteric coated tablets do NOT disintegrate well in the acidic stomach and therefore are absorbed in the alkaline small intestine

20
Q

Pharmaceutic (dissolution)

A

Tablets and capsules must disintegrate into small particles to dissolve into liquid. Tablets are not 100% drug. Excipients (fillers & inert substances) added to enhance drug dissolution.
Drugs in liquid form are already in solution.

Dissolution: dissolving of smaller particles in the GI fluid before absorption.
Liquid form medications more rapidly available for GI absorption than are
solids.

21
Q

Pharmaceutic (dissolution) (2)

A

-Food may enhance or inhibit absorption of medications
-Therefore, medications may often be dispensed with specific instructions for administration with or without food
-Other drugs may irritate the stomach, and taking them with food will reduce this effect

22
Q

Pharmacokinetics

A

Four processes
-Absorption: movement of drug particles from GI tract to body fluids
-Distribution: process by which drug becomes available to body fluids and body tissues
-Metabolism (biotransformation): converted or transformed into useable state
Main site of metabolism- LIVER
-Excretion (elimination): main route-KIDNEYS
other routes: hepatic metabolism, bile, feces, lungs, saliva & breast milk

23
Q

Absorption

A

Process of time that occurs between when a drug enters the body and the time it enters the blood stream

-Factors that affect absorption
-Enteric coated: (SR, ER & XR)
-Surface area of intestinal tract
-GI transport time
-Blood flow to GI tract
-Lipid soluble

24
Q

Absorption

A

-Hepatic First Pass: drug passes to the liver first
-Drugs don’t go directly into systemic circulation
-After oral intake → to intestinal lumen → liver (via portal vein)
-In liver: drugs may be metabolized to inactive form
-Then drugs can be excreted
-RESULT: REDUCED AMOUNT OF ACTIVE DRUG

25
Absorption
-Bioavailability: percentage of the administered drug dose that reaches the systemic circulation -Benefits: instant/complete effects, well controlled, large volumes given IV, GI irritants, give water soluble -Drawbacks: Costs, action irreversible, ↑ risk of infection, can be toxic to veins/surrounding tissues & blood clot development
26
Distribution
-Once a drug reaches the bloodstream it is ready to travel through body fluids to its site of action. -Areas with an extensive blood supply receive a drug rapidly, areas with less blood supply have a delay in distribution. -(Although a drug is delivered to the organ or tissues through blood vessels, the effect of the drug is in the tissues, not the blood vessels.
27
Distribution
-Protein-binding (page 20) -Free drug (drugs not bound to protein) are active & can cause a pharmacologic response -Volume of drug distribution (Vd) -Dependent on drug dose and its concentration in the body
28
Metabolism
-A series of chemical reactions that alter and convert drugs into water-soluble compounds for excretion. -Liver is primary site of metabolism -Half-life (page 50): the amount of time that is required to remove 50% of the blood concentration of a drug. -Short half-life: 4-8 hours (Heparin) -Long half-life: 24 hours or longer (Digoxin: half-life is 36 hours)-takes several days for body to completely eliminate the drug.
29
Excretion
-Kidneys: main route of elimination -Kidney disease: ↓ glomerular filtration rate (GFR) or ↓ renal tubular secretion = Slowed or impaired drug excretion -Renal dysfunction (elderly or due to disease) -Drug dosages need to be decreased -Creatinine clearance (CrCl): Renal function test and varies with age and gender. Normal range: 85-135ml/min.
30
Peak and Trough levels
-Peak drug level: the highest plasma concentration of drug at a specific time -Trough drug level: the lowest plasma concentration of a drug & it measures the rate at which the drug is eliminated (drawn immediately before the next dose of drug is given-regardless of administration route).
31
Pharmacodynamics
-For drugs to be effective, the medication must attach to an appropriate receptor site. -For a drug to be therapeutic, the chemicals found in that drug must be selective of the specific cell receptor site.
32
Pharmacodynamics
-Receptor theory -Agonists: drugs that produce an effect Ex.: isoproterenol (Isuprel)-stimulates beta 1 receptor -Antagonists: drugs that block a response Ex: cimetidine (Tagamet)-blocks the histamine (h2) receptor
33
Pharmacodynamics
Nonspecific drug effect Ex: bethanechol (Urecholine)-use to increase bladder contraction, but you will get other effects
34
Pharmacodynamics (cont’d)
Categories of drug action: 1. Stimulation 2. Depression (mucolytics) 3. Replacement (insulin) 4. Inhibition or killing of organisms (antibiotics) 5. Irritation (laxatives)
35
Therapeutic Window
-Drug concentration in plasma should be between the minimum effective concentration (MEC) in the plasma for obtaining desired drug action and the minimum toxic concentration, the toxic effect. Ex: If the therapeutic range is narrow (Digoxin: 0.5 to 2 ng/ml), the plasma drug level should be monitored periodically to avoid drug toxicity.
36
Definitions
Loading dose: large initial dose is given to achieve a rapid minimum effective concentration in the plasma Side (adverse) effect: physiologic effects not related to desired drug effects, most commonly results from drugs that lack specificity (may be undesirable or desirable) Adverse reaction: more severe than side effects (always undesirable, range from mild to life-threatening) Toxic effect: kidney damage (nephrotoxicity), liver damage (hepatotoxicity), and hearing damage (ototoxicity)
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