Intro to Pharmacology Flashcards
(29 cards)
This refers to the strength of binding between drug and receptor.
Affinity
A drug which binds to its “receptor” and produces its characteristic effect
Agonist
This is the maximum effect of which the drug is capable.
Efficacy
The “sine qua non” of drug effect. Simply put, as the dose of drug increases, the response should increase
Dose-Response
Refers to the dose required to produce a specific intensity of effect.
Potency
The science of dealing with actions of drugs on the body
Pharmacology
The science of drug preparation
Pharmacy
A molecule that prevents the action of other molecules, often by competing for a cellular receptor; opposite of agonist
Antagonist
An unintended pharmacological effect that occurs when a medication is administered correctly
Adverse Effect
Effect of a drug, other than the desired effect, sometimes in an organ other than the target organ.
Side effect
Separation between desired and undesired effects of a drug.
Selectivity
The movement of drugs within the body
Pharmacokinetics
The study of how people’s genes affect their response to medicines.
Pharmacogenetics
The breakdown of orally administered drugs in the liver and intestines.
First-pass effect
Medication administration route does NOT impact drug absorption.
FALSE
Pharmacokinetics is comprised of four main processes to describe the movement of drugs within the body?
TRUE
Drug absorption rate is impacted by fluid status, lipid solubility, blood flow, and surface area.
TRUE
What are the four stages of Pharmacokinetics?
1) Absorption 2) Distribution 3) Metabolism 4) Excretion
The first-pass effect impacts absorption of medications administered via the:
Oral route
Medications enter the body through the oral route alone?
FALSE
Medications can enter the body through the oral route, may be inhaled, may be absorbed through the skin, injected into a muscle, subcutaneous tissue, or the bloodstream, etc.
The first pass effect ______ the bioavailability of a medication administered via the oral route.
decreases/lessens
When a drug is given orally, it must be absorbed from the GI tract into _____ circulation.
portal
A patient with damage to the outer layer of skin (or stratum corneum) may experience a more rapid absorption of medication with topical application.
TRUE
The nurse applies a 14 mg nicotine patch to a patient’s upper arm to assist the patient to manage the symptoms of nicotine withdrawal while the patient is hospitalized. The nurse is aware that with transdermal application the medication will go directly into _____ circulation.
systemic
