Intro to PK/PD Past Quizzes

Question 1

N-acetylation of Hydralazine could lead to what disease?

Answer 1

systemic lupus erythematosus

Question 2

banned COX-2 inhibitor drug - causing cardiovascular side effects

Answer 2

rofecoxib

Question 3

paracetamol does not undergo this biotransformation process

Answer 3

acetylation

Question 4

tyrosine kinase receptor of insulin is ___

location

Answer 4

extracellular

Question 5

drug with the highest Vd (volume of distribution)

Answer 5

diazepam

Question 6

anti-angiogenic drug ranibizumab: use is for what disease?

Answer 6

benign prostatic hyperplasia

Question 7

naloxone & morphine exhibit what kind of antagonism?

Answer 7

physiologic

Question 8

2nd messenger of G-coupled receptor

Answer 8

adenylyl cyclase

Question 9

The serpentine receptor with 7 transmembrane segments and 3 intracellular loops

Answer 9

GPCR

Question 10

The type of metabolism in liver

Answer 10

microsomal

Question 11

The drug thalidomide is used to treat what disease

Answer 11

Multiple myeloma

Question 12

What is the relationship between bioaccumulation and

excretion

Answer 12

inverse

Question 13

If a drug has a half-life of 10 hours, what is its dosage

interval

Answer 13

• Once a day (10 hr x 4 / 2 = 20 hr interval)

Question 14

D/AUC : formula for ___

Answer 14

• Clearance

Question 15

Relapse happens when tamoxifen is used by Caucasian-Asians because they belong to what type of metabolizer

Answer 15

• Poor

Question 16

The effect of CYP enzyme inhibitor on drug therapeutic and side effects

Answer 16

• Prolonged

Question 17

Drug serum level measurement

Answer 17

• Concentration

Question 18

What is used to treat methamphetamine poisoning

Answer 18

• Ammonium chloride

Question 19

This is the maximal concentration of receptor sites in tissue

Answer 19

• Bmax

Question 20

Therapeutic index is a measure of?

Answer 20

• Safety

Question 21

What is the toxic metabolite of Paracetamol

a. capsaicin
b. mephenytoin
c. coumarin
d. N-acetyl-ρ-benzoquinone imine

Answer 21

D

Question 22

Type of mobilizer in which there is an increase in effectivity of
omeprazole
a. Poor 
b. Ultra Rapid 
c. Extensive
d. Rapid

Answer 22

A

Question 23

Peak effect in serum before oscillating gradually to zero

a. Hahaha
b. AUC
c. SSC
d. Sorry

Answer 23

C

Question 24

If t ½ is 4 hrs, what is the dosing interval??

a. Once a day
b. Twice a day
c. Thrice a day
d. Blah

Answer 24

C

Question 25

``` Simple nucleotide polymorphisms are important in this branch of pharmacology. a. Pharmacogenomics b. Pharmacoeconomics c. Pharmacoepidemiology d. Posology ```

Answer 25

A

Question 26

Na+-channel blockade is the mechanism of action of this drug: a. Red-tide poison b. Anesthesia c. *I forgot the choices HAHAHA sorry* d. Mushroom poison

Answer 26

B

Question 27

Inactive compound readily absorbed and distributed in the body a. Xenobiotic b. O..(forgot huhu) c. Prodrug d. Lead compound

Answer 27

C

Question 28

Ach-Atropine type of antagonism a. Chemical b. Physiologic c. Competitive d. Noncompetitive

Answer 28

B

Question 29

Diminished response over seconds or minutes after reaching an initial high level even in the continuous presence of an agonist a. Desensitization b. Stabilization c. Something else d. Anaphylaxis

Answer 29

A

Question 30

Propensity of drug combined to receptor is _______ a. Biosimilar b. Different c. Specific d. blah

Answer 30

B

Question 31

``` Rate of elimination/concentration a. Vd b. CL c. t1/2 d. ```

Answer 31

B

Question 32

``` Shortest half life a. Lidocaine b. Hydralazine. c. Chloroquine d. ```

Answer 32

B

Question 33

What is used to treat aspirin (ASA) poisoning? a. NaHCO3 b. NH4Cl

Answer 33

a

Question 34

Most abundant (enzyme?) isoform in the liver

Answer 34

- UGT-UDP

Question 35

Source of furanocoumarin?

Answer 35

- Grapefruit juice

Question 36

Serpentine receptor that is ―7-transmembrane‖ in description

Answer 36

- G protein coupled receptor

Question 37

Rofecoxib was banned recently. It belongs to what type of drug class?

Answer 37

- Anti-inflammatory

Question 38

Clopidogrel belongs to what type of drug class?

Answer 38

- Anti-platelet

Question 39

2nd messenger of G-coupled receptor

Answer 39

- Inositol triphosphate

Question 40

Effects are flushing, nausea, vomiting

Answer 40

- Ethanol