INTRO TO THE AUTONOMIC SYSTEM

Question 1

TYPE OF ANS FIBERS

from visceral structures
1st link in reflex arcs of ANS (visceral pain or vessel stretch)
asstd with chronic pain management

Answer 1

afferent fibers

Question 2

TYPE OF ANS FIBERS

accompanied by sensory fibers

Answer 2

efferent fibers

Question 3

Autonomic N.S.

interruption of transmission –> __________

Answer 3

spontaneous activity

Question 4

somatic n.s.

interruption of impulses —-> ___________

Answer 4

paralysis and atrophy

Question 5

principal site of ANS organization

Answer 5

hypothalamus

Question 6

Hypothalamus

function of:
Ant. Hypothalamus - ________
supraoptic hypothalamic nuclei - ___________

Answer 6

temperature regulation
water metabolism regulation

Question 7

SNS has a _______ physiologic response (mass reflex)

Answer 7

diffuse

Question 8

unpaired collateral ganglia

C
S
I

Answer 8

celiac ganglia
superior mesenteric ganglia
inferior mesenteric ganglia

Question 9

sympathetic: adrenoreceptors

Answer 9

alpha
beta

Question 10

parasympathetic: cholinoreceptors

Answer 10

muscarinic
nicotinic

Question 11

CHOLINERGIC NERVE TERMINALS

SYNTHESIS AND STORAGE

the rate limiting step is probably the transport of choline into the nerve terminal.

this transport can be inhibited by the research drug ________

Answer 11

hemicholinium

Question 12

CHOLINERGIC NERVE TERMINALS

SYNTHESIS AND STORAGE

ACTH is actively transported into its vesicles for storage by this vesicle associated transporter VAT

this process can be inhibited by another research drug, _________

Answer 12

Vesamicol

Question 13

CHOLINERGIC NERVE TERMINALS

RELEASE OF ACTH

several types of _______ are able to enter cholinergic nerve terminals and enzymatically alter synaptobrevin or one of the other docking or fusion proteins to prevent the release process

Answer 13

botulinum toxin

Question 14

ADRENERGIC TRANSMISSION

SYNTHESIS AND STORAGE:

tyrosine hydroxylase can be inhibited by _________

Answer 14

metyrosine

Question 15

ADRENERGIC TRANSMISSION

SYNTHESIS AND STORAGE:

VMAT can be inhibited by _________ resulting in depletion of transmitter stores

Answer 15

reserpine

Question 16

ADRENERGIC TRANSMISSION

SYNTHESIS AND STORAGE:

drugs that inhibit the distabilization of the wall of the vesicle

Answer 16

guanethidine

Question 17

ADRENERGIC TRANSMISSION

SYNTHESIS AND STORAGE:

drugs that inhibit the norepinephrine transporter NET

Answer 17

cocaine
TCA

Question 18

cell surface receptors that detect molecules outside the cell and activate cellular responses

heterotrimer: a, b, y subunits
classified based on distinctive alpha subunits

Answer 18

G PROTEINS

Question 19

g proteins classified:

——— - stimulatory G protein of adenylase cyclase

___________ - inhibitory G proteins of adenylase cyclase

__________ - G proteins coupling alpha receptors to phospholipase C

Answer 19

1. Gs
2. Gi and Go
3. Gq, and G11

Question 20

____________ a subunit regulates activity of its effector (adenyl cyclase, cGMP, phosphodiesterase, phospholipase channels)

Answer 20

activated GTP

Question 21

Alpha 1 Receptors decreases _______ and _______

Answer 21

IP3 and DAG

Question 22

Alpha 2 receptors decreases

Answer 22

CAMP

Question 23

B1, B2, B3 increases ___________

Answer 23

increases CAMP

Question 24

D1 increases ________

Answer 24

CAMP
G protein

Question 25

parasympathetic agonists choline esters A,M,C,B

Answer 25

ACTH Metacholine carbachol betanechol

Question 26

parasympathetic agonists DIRECT ACTING choline esters opthalmology: 1% drops of rapid meiosis minimal dose: vasodilation, decrease BP , reflex increase in HR

Answer 26

ACTH

Question 27

parasympathetic agonists DIRECT ACTING choline esters mainly muscarinic activity selective for GIT and GUT

Answer 27

BETANECHOL

Question 28

parasympathetic agonists DIRECT ACTING choline esters mainly muscarinic activity slows the heart and dilates peripheral BV terminate SV tachyarrhythmias increases intestinal tone

Answer 28

metacholine

Question 29

drugs for organophosphate poisoning includes A P D

Answer 29

atropine pralidoxime diacetylmonoxime

Question 30

parasympathetic antagonists premedication: mild cns stimulation high doses: restlessness. disorientation, hallucinations, and delirium avoid in tachycardic states

Answer 30

atropine

Question 31

specifically act on nicotinic receptors no selectivity towards PNS or SNS blocks entire ANS output non depolarizing, competitive antagonists except nicotine

Answer 31

ganglionic blockers