Introduction Flashcards
(21 cards)
What are pharmacodynamics
What a drug does to the body (bio effects an mechanism of action)
What are pharmacokinetics
What the body does to the drug (abs, dist, metab, excretion)
What is a drug
Any synthetic or natural sub which used in treatment, prevention or diagnosis of disease
( caffeine, illicit subs such as heroin, food additives)
How do drugs acts
Drugs act by binding to tragedy molecules selectivity
Bind to reg protein
What are some drug targets
Enzymes Carrier molecules Ion channels Receptors Rna DNA
What are receptors
Macromolecules that mediate the bio actions of hormones and neurotransmitters - endogenous subs
What are the two types of drugs
Agonists or antagonists
What is an agonists
Drug that binds to a receptor to produce a cellular response
What is an antagonist
Drug that blocks the actions of an agonist
What do agonists possess
Affinity and efficacy bind to receptors to activate them
What is affinity
Strength of association between ligand and recep
What is efficacy
Ability of an agonist to evoke a cellular response
What do antagonists do inaction
Bind to receptors but do not activate them
Possess affinity but lack efficacy
Block receptor activation by agonists
What sit he relationship between conc/dose and response
Hyperbolic or sigmoidal
What sit he conc of agonist which elicits a half maximal response
EC50
What is competitive antagonism
Binding of agonist and antagonist occur at same time - orthosteric site and is thus competitive and mutually exclusive
What is non comp antagonism
Agonist binds to orthosteric site and antagonist binds to sep allosteric site and is not competitive
Both may occupy receptor simultaneously
Activation cannot occur when antagonist is bound
What does an agonist along show
High potency and efficacy
What does an antagonist alone show
Lower potency but high efficacy
What does an agonist and non comp antagonist show
Potency and efficacy dec
What is pharmacology
Study of drugs what they are and what they do
Study manner which drugs affect living tissues and organs modified by chem substances
