Introduction to Drug Action

Question 1

What is pharmadynamics?

Answer 1

What a drug does to the body

Question 2

What is pharmacokinetics?

Answer 2

What the body does to a drug

Question 3

What is a drug?

Answer 3

Any single synthetic or natural substance of known structure used in treatment, prevention or diagnosis of disease

Question 4

What 2 things does selectivity rely on?

Answer 4

chemical structure of drug and drug only binding to ligand of precise structure

Question 5

What is an agonist?

Answer 5

drug that binds to receptor to produce cellular response

Question 6

What is an antagonist?

Answer 6

drug that block the actions of an agonist by binding to the same receptor

Question 7

What is efficacy?

Answer 7

Activation step

Question 8

How do you find Ec50?

Answer 8

when response is at 50%

Question 9

What is the relationship between response and agonist concentration in a semi-log graph?

Answer 9

sigmoidal

Question 10

In non-competitive antagonism where does the antagonist bind?

Answer 10

allosteric site