Introduction to Pain Management Lecture 1 Flashcards

(52 cards)

0
Q

According to Cascade of Pain Classification:

How is “Longevity” classified?

A

Acute and Chronic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Define Pain (as by the International Association for the Study of Pain)

A

“An unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

According to Cascade of Pain Classification, how long is pain endured to be considered “Acute”?

A

Acute is considered less than 3- 6 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

According to Cascade of Pain Classification, how long is pain endured to be considered “Chronic”?

A

Chronic is greater than 3- 6 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

According to Cascade of Pain Classification, how is the underlying pathophysiology classified as?

A

Nociceptive and Non-Nociceptive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Nociceptive pain is classified into what two categories?

A

Somatic and Viceral

*Associated with the stimulation of specific nociceptors and can be either somatic or viceral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Non-nociceptive pain is classified into what two categories?

A

Neuropathic and Idiopathic or Psychogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How is nociceptive, Somatic pain defined as?

A

Pain that has an identifiable locus as a result of tissue damage causing the release of chemicals from injured cells that mediate pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the characteristics of nociceptive, Somatic pain?

What is an example of Somatic pain?

A
  • Well localized (Type A nerve fibers)
  • Sharp pain in nature
  • Generally hurts at the point or area of stimulus

Example: A pin prick

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How is nociceptive, Viceral pain defined as?

A

Diffuse and can be referred to another area of the body. It is often associated with distention of an organ capsule or the obstruction of a hollow viscus. Also, it is often accompanied with autonomic reflexes such as nausea, diarrhea, or vomitting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the characteristics of nociceptive, Viceral pain?

What is an example of Viceral pain?

A
  • Dull
  • Cramping
  • Squeezing
  • Often vague in nature
  • Pressure pain that may radiate

Example: Generalized abdominal pain with nausea and vomitting for an appendicitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How is non-nociceptive, Neuropathic pain defined as?

A

Caused by damage to peripheral or central neural structures resulting in abnormal processing of painful stimuli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the characteristics of non-nociceptive, Neuropathic pain?
What is an example of Neuropathic pain?

A
  • Burning - Tingling
  • Shock-like - Stabbing sensation
  • Numbness - “Pins and Needles” sensation
  • Throbbing sensation

Example: “Boot toe”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is non-nociceptive, Idiopathic or Psychogenic pain defined as?

A

Associated with chronic pain states and is used to describe pain that has no apparent cause. Neither nociceptive or non-nociceptive mechanisms can be identified as the cause for pain, and psychological systems are commonly present

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is Algesia?

A

Increased sensitivity to pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

If it is “pain producing”, it is considered:

A

Algogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is Allodynia?

A

Where a normally non-harmful stimulus is perceived as painful

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

The absence of pain in the presence of a normally painful stimulus is the definition of _________.

A

Analgesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is Dysesthesia?

A

An unpleasant painful abnormal sensation, whether evoked or spontaneous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

A heightened response to a normally painful stimulus is considered to be ___________.

A

Hyperalgesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is Neuralgia?

A

Pain in the distribution of a peripheral nerve(s)

21
Q

This is the abnormal disturbance in the function of a nerve(s)

22
Q

What is Parathesia?

A

An abnormal sensation, whether evoked or spontaneous

23
Q

What are the FOUR processes that define Nociceptive Somatic Pain?

A
  • Transduction
  • Transmission
  • Perception
  • Modulation
24
In terms of Nociceptive Somatic Pain, what is Transduction?
Transformation of a noxious stimuli (chemical, mechanical, thermal) into an action potential
25
In terms of Nociceptive Somatic Pain, what is Transmission?
The process by which an action potential is conducted from the periphery to, but before, the CNS
26
In terms of Nociceptive Somatic Pain, what is Perception?
Occurs once the signal is recognized by several areas of the brain to include: - The Amygdala - Somatosensory area of the Cortex - Hypothalmus - The Anterior Cingulate Cortex
27
In terms of Nociceptive Somatic Pain, what is Modulation?
Involves altering neural afferent activity along the pain pathway; it can SUPPRESS or ENHANCE pain signals
28
What is another name for pain receptors?
Nociceptors, free nerve endings
29
Peripheral nociceptors that conduct stimuli to the _______ horn of the spinal cord, are categorized according to morphology. Morphology factors are: _________, __________, and ________.
- Dorsal - Diameter - Myelination - Conduction velocity
30
What are TWO common nerve fibers associated with the transduction of peripheral nociceptors?
- Larger myelinated A- delta nerve fibers: Primary afferent neurons that conduct action potentials at velocities between 6 and 30 meters/second and elicit FAST SHARP PAIN - Smaller unmyelinated C- nerve fibers: Conduct at velocities between 0.5 and 2 meters/second. AKA polymodal fibers because they respond to mechanical, chemical, and thermal injuries.
31
How are smaller unmyelinated C-fibers described as?
- Burning - Aching - Dull - Throbbing
32
Describe how inflammation and peripheral nociception occurs
When peripheral tissues (skin, bone, viscera, etc.) receive chemical, mechanical, and/or thermal stimuli or are either traumatized by either surgery or injury; a series of BIOMECHANICS events take place in peripheral pain transduction
33
Name the chemical mediators and neurotransmitters
- Substance P - Serotonin - Glutamate - Prostaglandins - Bradykinin - Cytokines - Histamine
34
Describe how chemical mediators and neurotransmitters work
They stimulate peripheral nociceptors, causing an INFLUX of SODIUM IONS to enter the NERVE FIBER membranes (DEPOLARIZATION) and a subsequent INFLUX of POTASSIUM IONS (REPOLARIZATION) resulting in an ACTION POTENTIAL generating a PAIN IMPULSE.
35
In which pathway does Transmission of nonciceptive pain occur?
Spinothalamic (anterolateral) Pathway
36
Where are the cell bodies of the primary afferent neurons (A-delta and C-fibers) located on the spinal cord?
The Dorsal Root Ganglia
37
Upon entering the ______ horn, these fibers _________ and descend or ascend several spinal segments in the _____________.
- Dorsal - Segregate - Tract of Lissauer
38
What happens after the pain impulse leaves the Tract of Lissauer?
The axons of the primary afferent enter the gray matter of the dorsal horn where they synapse with the second-order neurons and terminate primarily in the Laminae of Rexed.
39
At which laminae, in the Laminae of Rexed, do the primary afferent neurons terminate at?
I, II, and V
40
How many types of second-order neurons are there? | What are they?
Two types 1. Nociceptive neurons: which receive input solely from primary A-delta nerve fibers and C-fibers 2. Wide-Dynamic-Range (WDR) neurons: receive input from both nociceptive (A-delta and C-fibers) and non-nociceptive (A-beta) primary afferents
41
How are Wide-Dynamic-Range (WDR) neurons activated?
A variety of stimulants both innocuous and noxious
42
How do second-order neurons cross the the midline of the spinal cord? Then what do they do?
Through the Anterior Commissure | They ascend through the anterolateral pathway of the spinothalamic tract up to the Thalamus.
43
Where do second-order neurons synapse with third-order neurons? Then what do third-order neurons do?
Lateral Thalamus and the Intralaminar Nuclei | Send projections to the Cerebral Cortex
44
Once third-order neurons send projections (signals) to Cerebral Cortex what occurs?
Perception occurs once the signal is recognized by the different areas of the brain
45
Where does Modulation occur? | What can it do to pain?
Within the descending efferent pathways | It can either SUPPRESS or ENHANCE pain
46
What is considered the body's "Pain Control System" or "Analgesia System"?
The Descending Efferent Modulating Pathway from the brain
47
Where do descending axons come from that synapse with and suppress pain transmission to the brainstem and the spinal cord dorsal horn?
Descending axons arise from: - The Cerebral Cortex - Hypothalamus - Thalamus - Periaquaductal Gray Matter - Raphe Magnus Nucleus - Locus Ceruleus (in the Pons) via the Dorsolateral Funiculis
48
What play an inhibitory role in suppressing pain during Modulation? What are they?
Endogenous Opioids - Endorphins - Enkephalins - Dynonorphins
49
What occurs with the presence of "Central Sensitization"?
Pain Modulation is enhanced
50
With pain-modulating neurotransmitters, what are the TWO excitatory neurotransmitters? What receptors do they bind to?
Substance P and Glutamate Substance P: Neurokinin 1 and 2 (NK1) (NK2) Glutamate: NMDA, AMPA, and Kainate
51
With pain-modulating neurotransmitters, what are the FIVE inhibitory neurotransmitters? What receptor do they bind to?
- Glycine: Chloride linked (GlyR) - GABA: GABAa, GABAb, GABAc - Enkephalins: Mu, Delta, Kappa - Serotonin: 5-HT (5-HT1-3) - Norepinephrine: Alpha 2 adrenergic